Q15077 · P2RY6_HUMAN
- ProteinP2Y purinoceptor 6
- GeneP2RY6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids328 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameP2Y purinoceptor 6
- Short namesP2Y6
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ15077
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-27 | Extracellular | ||||
Sequence: MEWDNGTGQALGLPPTTCVYRENFKQL | ||||||
Transmembrane | 28-48 | Helical; Name=1 | ||||
Sequence: LLPPVYSAVLAAGLPLNICVI | ||||||
Topological domain | 49-62 | Cytoplasmic | ||||
Sequence: TQICTSRRALTRTA | ||||||
Transmembrane | 63-83 | Helical; Name=2 | ||||
Sequence: VYTLNLALADLLYACSLPLLI | ||||||
Topological domain | 84-101 | Extracellular | ||||
Sequence: YNYAQGDHWPFGDFACRL | ||||||
Transmembrane | 102-122 | Helical; Name=3 | ||||
Sequence: VRFLFYANLHGSILFLTCISF | ||||||
Topological domain | 123-144 | Cytoplasmic | ||||
Sequence: QRYLGICHPLAPWHKRGGRRAA | ||||||
Transmembrane | 145-165 | Helical; Name=4 | ||||
Sequence: WLVCVAVWLAVTTQCLPTAIF | ||||||
Topological domain | 166-194 | Extracellular | ||||
Sequence: AATGIQRNRTVCYDLSPPALATHYMPYGM | ||||||
Transmembrane | 195-215 | Helical; Name=5 | ||||
Sequence: ALTVIGFLLPFAALLACYCLL | ||||||
Topological domain | 216-236 | Cytoplasmic | ||||
Sequence: ACRLCRQDGPAEPVAQERRGK | ||||||
Transmembrane | 237-257 | Helical; Name=6 | ||||
Sequence: AARMAVVVAAAFAISFLPFHI | ||||||
Topological domain | 258-280 | Extracellular | ||||
Sequence: TKTAYLAVRSTPGVPCTVLEAFA | ||||||
Transmembrane | 281-303 | Helical; Name=7 | ||||
Sequence: AAYKGTRPFASANSVLDPILFYF | ||||||
Topological domain | 304-328 | Cytoplasmic | ||||
Sequence: TQKKFRRRPHELLQKLTAKWQRQGR |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 435 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000070028 | 1-328 | P2Y purinoceptor 6 | |||
Sequence: MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR | ||||||
Glycosylation | 5 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 99↔177 | |||||
Sequence: CRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length328
- Mass (Da)36,429
- Last updated1996-11-01 v1
- ChecksumAAD6C55A43818107
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7P0TA46 | A0A7P0TA46_HUMAN | P2RY6 | 355 | ||
F5GX90 | F5GX90_HUMAN | P2RY6 | 128 | ||
F5GYF3 | F5GYF3_HUMAN | P2RY6 | 245 | ||
F5H7H9 | F5H7H9_HUMAN | P2RY6 | 167 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 2-3 | in Ref. 2 | ||||
Sequence: Missing |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X97058 EMBL· GenBank· DDBJ | CAA65770.1 EMBL· GenBank· DDBJ | mRNA | ||
U52464 EMBL· GenBank· DDBJ | AAB03572.1 EMBL· GenBank· DDBJ | mRNA | ||
AF007892 EMBL· GenBank· DDBJ | AAB80713.1 EMBL· GenBank· DDBJ | mRNA | ||
AF007891 EMBL· GenBank· DDBJ | AAB80712.1 EMBL· GenBank· DDBJ | mRNA | ||
AF218005 EMBL· GenBank· DDBJ | AAG17247.1 EMBL· GenBank· DDBJ | mRNA | ||
AF498920 EMBL· GenBank· DDBJ | AAM18129.1 EMBL· GenBank· DDBJ | mRNA | ||
BT006771 EMBL· GenBank· DDBJ | AAP35417.1 EMBL· GenBank· DDBJ | mRNA | ||
BC000571 EMBL· GenBank· DDBJ | AAH00571.1 EMBL· GenBank· DDBJ | mRNA | ||
BC009391 EMBL· GenBank· DDBJ | AAH09391.1 EMBL· GenBank· DDBJ | mRNA |