Q15021 · CND1_HUMAN

  • Protein
    Condensin complex subunit 1
  • Gene
    NCAPD2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719).
May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcondensed chromosome
Cellular Componentcondensed chromosome, centromeric region
Cellular Componentcondensed nuclear chromosome
Cellular Componentcondensin complex
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentmembrane
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular Functionhistone binding
Biological Processcell division
Biological Processmeiotic chromosome condensation
Biological Processmitotic chromosome condensation
Biological Processpositive regulation of chromosome condensation
Biological Processpositive regulation of chromosome segregation
Biological Processpositive regulation of chromosome separation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Condensin complex subunit 1
  • Alternative names
    • Chromosome condensation-related SMC-associated protein 1
    • Chromosome-associated protein D2 (hCAP-D2)
    • Non-SMC condensin I complex subunit D2
    • XCAP-D2 homolog

Gene names

    • Name
      NCAPD2
    • Synonyms
      CAPD2, CNAP1, KIAA0159

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q15021
  • Secondary accessions
    • D3DUR4
    • Q8N6U3

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Cytoplasm
Chromosome
Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Keywords

Disease & Variants

Involvement in disease

Microcephaly 21, primary, autosomal recessive (MCPH21)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH21 features include mild intellectual disability, intrauterine growth retardation, short stature, and microcephaly.
  • See also
    MIM:617983
Natural variants in MCPH21
Variant IDPosition(s)ChangeDescription
VAR_0809538F>Sin MCPH21; uncertain significance

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_0809538in MCPH21; uncertain significance
Natural variantVAR_02442183in dbSNP:rs714774
Natural variantVAR_057511580in dbSNP:rs17725914
Natural variantVAR_024422797in dbSNP:rs10849482
Natural variantVAR_0587131321in dbSNP:rs2240871
Mutagenesis1343-1348Abolishes localization to the nucleus, while it only reduces chromosome binding.
Mutagenesis1358-1360Abolishes localization to the nucleus, while it only reduces chromosome binding.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,506 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00000950351-1401UniProtCondensin complex subunit 1
Modified residue (large scale data)13PRIDEPhosphoserine
Modified residue20UniProtPhosphoserine
Modified residue585UniProtPhosphoserine
Modified residue (large scale data)585PRIDEPhosphoserine
Modified residue (large scale data)586PRIDEPhosphothreonine
Modified residue (large scale data)603PRIDEPhosphoserine
Modified residue (large scale data)608PRIDEPhosphoserine
Modified residue (large scale data)972PRIDEPhosphoserine
Modified residue1310UniProtPhosphoserine
Modified residue (large scale data)1310PRIDEPhosphoserine
Modified residue1315UniProtPhosphoserine
Modified residue (large scale data)1315PRIDEPhosphoserine
Modified residue (large scale data)1325PRIDEPhosphotyrosine
Modified residue1330UniProtPhosphoserine
Modified residue (large scale data)1330PRIDEPhosphoserine
Modified residue1331UniProtPhosphothreonine
Modified residue (large scale data)1331PRIDEPhosphothreonine
Modified residue1333UniProtPhosphoserine
Modified residue (large scale data)1333PRIDEPhosphoserine
Modified residue1339UniProtPhosphothreonine
Modified residue (large scale data)1339PRIDEPhosphothreonine
Modified residue1366UniProtPhosphoserine
Modified residue (large scale data)1366PRIDEPhosphoserine
Modified residue1367UniProtPhosphoserine
Modified residue (large scale data)1367PRIDEPhosphoserine
Modified residue1370UniProtPhosphoserine
Modified residue (large scale data)1370PRIDEPhosphoserine
Modified residue1371UniProtPhosphoserine
Modified residue (large scale data)1371PRIDEPhosphoserine
Modified residue1376UniProtPhosphoserine
Modified residue1384UniProtPhosphothreonine; by CDK1
Modified residue1389UniProtPhosphothreonine; by CDK1
Modified residue1395UniProtPhosphoserine

Post-translational modification

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q15021NCAPG Q9BPX32EBI-1044041, EBI-970214
BINARY Q15021NCAPH Q150038EBI-1044041, EBI-1046410

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region1-603Interactions with SMC2 and SMC4
Region576-611Disordered
Compositional bias578-601Polar residues
Compositional bias956-975Basic and acidic residues
Region956-978Disordered
Region1303-1401Disordered
Compositional bias1313-1339Polar residues
Motif1342-1362Bipartite nuclear localization signal

Domain

The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region.

Sequence similarities

Belongs to the CND1 (condensin subunit 1) family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,401
  • Mass (Da)
    157,182
  • Last updated
    2009-09-22 v3
  • Checksum
    35E31642B94B513D
MAPQMYEFHLPLSPEELLKSGGVNQYVVQEVLSIKHLPPQLRAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSRHSQELPAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDIRHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDADLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEDVKGRIYQLLAKASYKKAIILTREATGHFQESEPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKPNMSDPEESRGNDELVKQEMLVQYLQDAYSFSRKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGLDEKFPQDYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKDPKEKNTSSETTMEEELGLVGATADDTEAELIRGICEMELLDGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFSAFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPSTGSRYQPLASTASDNDFVTPEPRRTTRRHPNTQQRASKKKPKVVFSSDESSEEDLSAEMTEDETPKKTTPILRASARRHRS

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E7EN77E7EN77_HUMANNCAPD2919
F5GZK7F5GZK7_HUMANNCAPD2118
F5H431F5H431_HUMANNCAPD281

Sequence caution

The sequence BAA09930.2 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias578-601Polar residues
Compositional bias956-975Basic and acidic residues
Sequence conflict1062in Ref. 1; BAA09930
Sequence conflict1218in Ref. 1; BAA09930
Compositional bias1313-1339Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D63880
EMBL· GenBank· DDBJ
BAA09930.2
EMBL· GenBank· DDBJ
mRNA Different initiation
AC006064
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471116
EMBL· GenBank· DDBJ
EAW88788.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471116
EMBL· GenBank· DDBJ
EAW88789.1
EMBL· GenBank· DDBJ
Genomic DNA
BC028182
EMBL· GenBank· DDBJ
AAH28182.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp