Q14D04 · MELT_HUMAN
- ProteinVentricular zone-expressed PH domain-containing protein homolog 1
- GeneVEPH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids833 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | phosphatidylinositol-5-phosphate binding | |
Biological Process | negative regulation of SMAD protein signal transduction | |
Biological Process | negative regulation of transforming growth factor beta receptor signaling pathway | |
Biological Process | regulation of signal transduction |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVentricular zone-expressed PH domain-containing protein homolog 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ14D04
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_034692 | 208 | in dbSNP:rs34559487 | |||
Sequence: S → C | ||||||
Natural variant | VAR_034693 | 263 | in dbSNP:rs1378796 | |||
Sequence: V → G | ||||||
Natural variant | VAR_034694 | 271 | in dbSNP:rs1378795 | |||
Sequence: S → C | ||||||
Natural variant | VAR_034695 | 319 | in dbSNP:rs11923380 | |||
Sequence: M → V | ||||||
Natural variant | VAR_034696 | 329 | in dbSNP:rs34823544 | |||
Sequence: L → V | ||||||
Natural variant | VAR_034697 | 365 | in dbSNP:rs16827563 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_061683 | 501 | in dbSNP:rs59504298 | |||
Sequence: S → L | ||||||
Natural variant | VAR_034698 | 522 | in dbSNP:rs11918974 | |||
Sequence: S → P |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,123 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000297955 | 1-833 | UniProt | Ventricular zone-expressed PH domain-containing protein homolog 1 | |||
Sequence: MHQLFRLVLGQKDLSRAGDLFSLDDSEIEDSLTEALEQIKIISSSSDYQTNNNDQAVVEICITRITTAIRETESIEKHAKALVGLWDSCLEHNLRPFGKDEDTPHAKIASDIMSCILQNYNRPPVMALAIPIAVKFLHRGNKELCRNMSNYLSLAAITKADLLADHTEVIVKSILQGNTMLLRVLPAVYEKQPQPINRHLTELLALMSQLEQPEQYHLLRLLHVAAKKKQLEVVQKCIPFLIGHLKDSTHNDIILNILIEIAVYEPVALNSFLPMLKEIGERFPYLTGQMARIYGAVGHVDEERARSCLTYLVSQLANMEHSFHHILLLEIKSITDTFSSILGPQSRDIFRMSNSFTAIAKLLTRQLENTKAGSGRRKISTEIEFPEKLEETKLIVTENEDHEKLQVKIQAFEDKINAGSNTPGSIRRYSLGQVSKEERKNIRFNRSKSLAFHTMLTKGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGESSVSYPNIIHIDSENLSETVKENSQEETPETTASPIEYQDKLYLHLKKNLSKVKAYAMEIGKKIPVPDQCTIEDTVRSCVAKLFFTCSLKGHYCLYSKSSFILISQEPQPWIQIMFLFQQSLFPEPLSIQSHSVQFLRALWEKTQAGGAHSFETAMMESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVAVAQAKERESREVTTYL | |||||||
Modified residue (large scale data) | 353 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 380 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 420 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 422 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 425 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 430 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 449 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 462 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 529 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts with TGFBR1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q14D04 | SCRIB Q14160 | 2 | EBI-1043669, EBI-357345 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 201-319 | Interaction with TGFBR1 | ||||
Sequence: TELLALMSQLEQPEQYHLLRLLHVAAKKKQLEVVQKCIPFLIGHLKDSTHNDIILNILIEIAVYEPVALNSFLPMLKEIGERFPYLTGQMARIYGAVGHVDEERARSCLTYLVSQLANM | ||||||
Region | 458-505 | Disordered | ||||
Sequence: KGVGSDDGEDENRGDIPASISLSEIDPLGQGNDKLPFKTDTERSQLGE | ||||||
Region | 663-833 | Interaction with TGFBR1 | ||||
Sequence: ESTFPQQKDLDQVQLHLEEVRFFDVFGFSETAGAWQCFMCNNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVAVAQAKERESREVTTYL | ||||||
Domain | 716-819 | PH | ||||
Sequence: QPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNKTYVFKAKDEKNAEEWLQCINVAVA |
Domain
The PH domain is required for membrane targeting.
Sequence similarities
Belongs to the MELT/VEPH family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q14D04-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length833
- Mass (Da)94,745
- Last updated2006-08-22 v1
- Checksum34995B4AB43474A4
Q14D04-2
- Name2
- Differences from canonical
- 626-670: Missing
Q14D04-3
- Name3
Q14D04-4
- Name4
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_047655 | 177 | in isoform 4 | |||
Sequence: G → V | ||||||
Alternative sequence | VSP_027431 | 178-213 | in isoform 3 | |||
Sequence: NTMLLRVLPAVYEKQPQPINRHLTELLALMSQLEQP → MVRKLSLGTCFGRYLKVFSSSIYGLWEARPRVLEAN | ||||||
Alternative sequence | VSP_047656 | 178-833 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_027432 | 214-833 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 259 | in Ref. 2; BAB55243 | ||||
Sequence: I → M | ||||||
Alternative sequence | VSP_027433 | 626-670 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 808 | in Ref. 2; BAB55243 | ||||
Sequence: E → A |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB051479 EMBL· GenBank· DDBJ | BAB21783.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK022666 EMBL· GenBank· DDBJ | BAB14165.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK027625 EMBL· GenBank· DDBJ | BAB55243.1 EMBL· GenBank· DDBJ | mRNA | ||
AL713656 EMBL· GenBank· DDBJ | CAD28465.2 EMBL· GenBank· DDBJ | mRNA | ||
AC020630 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC092944 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471052 EMBL· GenBank· DDBJ | EAW78705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471052 EMBL· GenBank· DDBJ | EAW78706.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471052 EMBL· GenBank· DDBJ | EAW78707.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC042159 EMBL· GenBank· DDBJ | AAH42159.1 EMBL· GenBank· DDBJ | mRNA | ||
BC057999 EMBL· GenBank· DDBJ | AAH57999.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101660 EMBL· GenBank· DDBJ | AAI01661.1 EMBL· GenBank· DDBJ | mRNA | ||
BC111017 EMBL· GenBank· DDBJ | AAI11018.1 EMBL· GenBank· DDBJ | mRNA | ||
BC113555 EMBL· GenBank· DDBJ | AAI13556.1 EMBL· GenBank· DDBJ | mRNA |