Q14BW6 · Q14BW6_MOUSE
- ProteinDeoxyribonuclease
- GeneDnase1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids284 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 100 | |||||
Sequence: E | ||||||
Active site | 156 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | nuclear envelope | |
Cellular Component | zymogen granule | |
Molecular Function | actin binding | |
Molecular Function | deoxyribonuclease I activity | |
Biological Process | DNA catabolic process |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDeoxyribonuclease
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ14BW6
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MRYTGLMGTLLTLVNLLQLAGT | ||||||
Chain | PRO_5014306910 | 23-284 | Deoxyribonuclease | |||
Sequence: LRIAAFNIRTFGETKMSNATLSVYFVKILSRYDIAVIQEVRDSHLVAVGKLLDELNRDKPDTYRYVVSEPLGRKSYKEQYLFVYRPDQVSILDSYQYDDGCEPCGNDTFSREPAIVKFFSPYTEVQEFAIVPLHAAPTEAVSEIDALYDVYLDVWQKWGLEDIMFMGDFNAGCSYVTSSQWSSIRLRTSPIFQWLIPDSADTTVTSTHCAYDRIVVAGALLQAAVVPNSAVPFDFQAEYGLSNQLAEAISDHYPVEVTLRKI | ||||||
Disulfide bond | 123↔126 | |||||
Sequence: CEPC | ||||||
Disulfide bond | 195↔231 | Essential for enzymatic activity | ||||
Sequence: CSYVTSSQWSSIRLRTSPIFQWLIPDSADTTVTSTHC |
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 27-274 | Endonuclease/exonuclease/phosphatase | ||||
Sequence: AFNIRTFGETKMSNATLSVYFVKILSRYDIAVIQEVRDSHLVAVGKLLDELNRDKPDTYRYVVSEPLGRKSYKEQYLFVYRPDQVSILDSYQYDDGCEPCGNDTFSREPAIVKFFSPYTEVQEFAIVPLHAAPTEAVSEIDALYDVYLDVWQKWGLEDIMFMGDFNAGCSYVTSSQWSSIRLRTSPIFQWLIPDSADTTVTSTHCAYDRIVVAGALLQAAVVPNSAVPFDFQAEYGLSNQLAEAISDH |
Sequence similarities
Belongs to the DNase I family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length284
- Mass (Da)32,027
- Last updated2006-08-22 v1
- Checksum8682E20515EEB510
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC115571 EMBL· GenBank· DDBJ | AAI15572.1 EMBL· GenBank· DDBJ | mRNA |