Q14BW6 · Q14BW6_MOUSE

  • Protein
    Deoxyribonuclease
  • Gene
    Dnase1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products.
    EC:3.1.21.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for active site.

128420406080100120140160180200220240260280
TypeIDPosition(s)Description
Active site100
Active site156

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentnuclear envelope
Cellular Componentzymogen granule
Molecular Functionactin binding
Molecular Functiondeoxyribonuclease I activity
Biological ProcessDNA catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyribonuclease

Gene names

    • Name
      Dnase1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q14BW6

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_501430691023-284Deoxyribonuclease
Disulfide bond123↔126
Disulfide bond195↔231Essential for enzymatic activity

Keywords

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-274Endonuclease/exonuclease/phosphatase

Sequence similarities

Belongs to the DNase I family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    284
  • Mass (Da)
    32,027
  • Last updated
    2006-08-22 v1
  • Checksum
    8682E20515EEB510
MRYTGLMGTLLTLVNLLQLAGTLRIAAFNIRTFGETKMSNATLSVYFVKILSRYDIAVIQEVRDSHLVAVGKLLDELNRDKPDTYRYVVSEPLGRKSYKEQYLFVYRPDQVSILDSYQYDDGCEPCGNDTFSREPAIVKFFSPYTEVQEFAIVPLHAAPTEAVSEIDALYDVYLDVWQKWGLEDIMFMGDFNAGCSYVTSSQWSSIRLRTSPIFQWLIPDSADTTVTSTHCAYDRIVVAGALLQAAVVPNSAVPFDFQAEYGLSNQLAEAISDHYPVEVTLRKI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC115571
EMBL· GenBank· DDBJ
AAI15572.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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