Q14BI2 · GRM2_MOUSE

  • Protein
    Metabotropic glutamate receptor 2
  • Gene
    Grm2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.

Features

Showing features for binding site.

1872100200300400500600700800
TypeIDPosition(s)Description
Binding site145L-glutamate (UniProtKB | ChEBI)
Binding site166-168L-glutamate (UniProtKB | ChEBI)
Binding site216L-glutamate (UniProtKB | ChEBI)
Binding site295L-glutamate (UniProtKB | ChEBI)
Binding site377L-glutamate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentastrocyte projection
Cellular Componentaxon
Cellular Componentdendrite
Cellular Componentglutamatergic synapse
Cellular Componentneuron projection
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentpresynaptic membrane
Molecular Functioncalcium channel regulator activity
Molecular Functiongroup II metabotropic glutamate receptor activity
Molecular Functionscaffold protein binding
Biological Processbehavioral response to nicotine
Biological ProcessG protein-coupled glutamate receptor signaling pathway
Biological Processgene expression
Biological Processglutamate receptor signaling pathway
Biological Processglutamate secretion
Biological Processintracellular glutamate homeostasis
Biological Processlong-term synaptic depression
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpresynaptic modulation of chemical synaptic transmission
Biological Processregulation of dopamine secretion
Biological Processregulation of glutamate secretion
Biological Processregulation of response to drug
Biological Processregulation of synaptic transmission, glutamatergic
Biological Processresponse to cocaine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Metabotropic glutamate receptor 2
  • Short names
    mGluR2

Gene names

    • Name
      Grm2
    • Synonyms
      Gprc1b, Mglur2

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q14BI2

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain19-568Extracellular
Transmembrane569-589Helical; Name=1
Topological domain590-604Cytoplasmic
Transmembrane605-625Helical; Name=2
Topological domain626-633Extracellular
Transmembrane634-651Helical; Name=3
Topological domain652-679Cytoplasmic
Transmembrane680-700Helical; Name=4
Topological domain701-726Extracellular
Transmembrane727-747Helical; Name=5
Topological domain748-760Cytoplasmic
Transmembrane761-781Helical; Name=6
Topological domain782-798Extracellular
Transmembrane799-819Helical; Name=7
Topological domain820-872Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000030624919-872Metabotropic glutamate receptor 2
Disulfide bond50↔92
Glycosylation203N-linked (GlcNAc...) asparagine
Disulfide bond234↔518
Glycosylation286N-linked (GlcNAc...) asparagine
Glycosylation338N-linked (GlcNAc...) asparagine
Disulfide bond355↔362
Disulfide bond400↔407
Glycosylation402N-linked (GlcNAc...) asparagine
Disulfide bond500↔519
Disulfide bond504↔522
Disulfide bond525↔537
Disulfide bond540↔553
Glycosylation547N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in neurons in brain cortex (at protein level).

Gene expression databases

Interaction

Subunit

Interacts with TAMALIN (By similarity).
Interacts with HTR2A

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region677-685Important for interaction with HTR2A

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    872
  • Mass (Da)
    95,887
  • Last updated
    2007-10-02 v2
  • Checksum
    FE1726B0684E256D
MESLLRFLALLLLRGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATLSDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQNLDPWNNSRNPWFREFWEERFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGNGRYRYQKVGYWAEGLTLDTSIIPWASPSAGTLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGIGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQLVPTVCNGREVVDSTTSSL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0J9YVF0A0A0J9YVF0_MOUSEGrm2594
A0A0J9YU95A0A0J9YU95_MOUSEGrm2381

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC152452
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC115866
EMBL· GenBank· DDBJ
AAI15867.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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