Q14AK4 · ZDH11_MOUSE

  • Protein
    Palmitoyltransferase ZDHHC11
  • Gene
    Zdhhc11
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (PubMed:23687301).
Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (PubMed:23687301).
May play a role in cell proliferation (By similarity).
Has also a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response (PubMed:29429998).
Functions as an adapter that recruits IRF3 to STING1 to promote the activation of that key transcriptional regulator of type I interferon (IFN)-dependent immune response (PubMed:29429998).

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site158S-palmitoyl cysteine intermediate

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendosome membrane
Cellular ComponentGolgi apparatus
Molecular Functionprotein-cysteine S-palmitoyltransferase activity
Biological Processantiviral innate immune response
Biological Processpeptidyl-L-cysteine S-palmitoylation
Biological Processpositive regulation of defense response to virus by host
Biological Processprotein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Palmitoyltransferase ZDHHC11
  • EC number
  • Alternative names
    • DHHC-containing protein 10
      (DHHC10(z11)
      )
    • Zinc finger DHHC domain-containing protein 11 (DHHC-11)

Gene names

    • Name
      Zdhhc11

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q14AK4
  • Secondary accessions
    • Q5Y5T4

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-46Cytoplasmic
Transmembrane47-67Helical
Topological domain68-75Lumenal
Transmembrane76-96Helical
Topological domain97-170Cytoplasmic
Transmembrane171-191Helical
Topological domain192-234Lumenal
Transmembrane235-255Helical
Topological domain256-347Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Homozygous knockout mice are viable and do not show overt phenotype (PubMed:29429998).
Composition and number of major immune cells is normal but mice are more susceptible to DNA-virus infection and death than their wild-type counterpart (PubMed:29429998).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis158Loss of protein-cysteine S-palmitoyltransferase activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 21 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004137641-347Palmitoyltransferase ZDHHC11

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with IRF3 and STING1; in presence of DNA viruses recruits IRF3 to STING1 promoting IRF3 phosphorylation and activation.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain128-178DHHC
Region291-332Disordered

Domain

The DHHC domain is required for palmitoyltransferase activity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    39,660
  • Last updated
    2006-09-05 v2
  • Checksum
    1D2C92540424C697
MKEMNICGINKNWVLPEAQENNVKKFLPRPLSRVNGWSPPLHSFQAISWITYLAMSIVTFGIFIPFLPYSWKYAANIVMGGVFIFHLIVHLIAITIDPADTNVRLKKDYTQPVPAFDRSKHTHVIQNQYCHLCEVTASKKAKHCSACNKCVSGFDHHCKWLNNCVGRRNYWFFFWSVASAAVGILGVMIILCYICIQYFVNPDELRTDPLYKEIISENTWLLFLSLWPVPVKTPIVLSIAVMALLLAIASFVMLGHLLIFHLYLITKNMSTFDYLMKTRFKKNLHPAEEKELPLQKKGDLPQEKSDNWAWPKSPPRVGSQKFPVSTLSPKSSVCFVASPPKICHSED

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1Y7VP32A0A1Y7VP32_MOUSEZdhhc11151
A0A1Y7VLH9A0A1Y7VLH9_MOUSEZdhhc11323

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY668948
EMBL· GenBank· DDBJ
AAU89702.1
EMBL· GenBank· DDBJ
mRNA
CT010471
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC116803
EMBL· GenBank· DDBJ
AAI16804.2
EMBL· GenBank· DDBJ
mRNA
BC116807
EMBL· GenBank· DDBJ
AAI16808.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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