Q14AK4 · ZDH11_MOUSE
- ProteinPalmitoyltransferase ZDHHC11
- GeneZdhhc11
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids347 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (PubMed:23687301).
Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (PubMed:23687301).
May play a role in cell proliferation (By similarity).
Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (PubMed:23687301).
May play a role in cell proliferation (By similarity).
Has also a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response (PubMed:29429998).
Functions as an adapter that recruits IRF3 to STING1 to promote the activation of that key transcriptional regulator of type I interferon (IFN)-dependent immune response (PubMed:29429998).
Functions as an adapter that recruits IRF3 to STING1 to promote the activation of that key transcriptional regulator of type I interferon (IFN)-dependent immune response (PubMed:29429998).
Catalytic activity
- hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 158 | S-palmitoyl cysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endosome membrane | |
Cellular Component | Golgi apparatus | |
Molecular Function | protein-cysteine S-palmitoyltransferase activity | |
Biological Process | antiviral innate immune response | |
Biological Process | peptidyl-L-cysteine S-palmitoylation | |
Biological Process | positive regulation of defense response to virus by host | |
Biological Process | protein targeting to membrane |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePalmitoyltransferase ZDHHC11
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ14AK4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endosome membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-46 | Cytoplasmic | ||||
Sequence: MKEMNICGINKNWVLPEAQENNVKKFLPRPLSRVNGWSPPLHSFQA | ||||||
Transmembrane | 47-67 | Helical | ||||
Sequence: ISWITYLAMSIVTFGIFIPFL | ||||||
Topological domain | 68-75 | Lumenal | ||||
Sequence: PYSWKYAA | ||||||
Transmembrane | 76-96 | Helical | ||||
Sequence: NIVMGGVFIFHLIVHLIAITI | ||||||
Topological domain | 97-170 | Cytoplasmic | ||||
Sequence: DPADTNVRLKKDYTQPVPAFDRSKHTHVIQNQYCHLCEVTASKKAKHCSACNKCVSGFDHHCKWLNNCVGRRNY | ||||||
Transmembrane | 171-191 | Helical | ||||
Sequence: WFFFWSVASAAVGILGVMIIL | ||||||
Topological domain | 192-234 | Lumenal | ||||
Sequence: CYICIQYFVNPDELRTDPLYKEIISENTWLLFLSLWPVPVKTP | ||||||
Transmembrane | 235-255 | Helical | ||||
Sequence: IVLSIAVMALLLAIASFVMLG | ||||||
Topological domain | 256-347 | Cytoplasmic | ||||
Sequence: HLLIFHLYLITKNMSTFDYLMKTRFKKNLHPAEEKELPLQKKGDLPQEKSDNWAWPKSPPRVGSQKFPVSTLSPKSSVCFVASPPKICHSED |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Homozygous knockout mice are viable and do not show overt phenotype (PubMed:29429998).
Composition and number of major immune cells is normal but mice are more susceptible to DNA-virus infection and death than their wild-type counterpart (PubMed:29429998).
Composition and number of major immune cells is normal but mice are more susceptible to DNA-virus infection and death than their wild-type counterpart (PubMed:29429998).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 158 | Loss of protein-cysteine S-palmitoyltransferase activity. | ||||
Sequence: C → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 21 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000413764 | 1-347 | Palmitoyltransferase ZDHHC11 | |||
Sequence: MKEMNICGINKNWVLPEAQENNVKKFLPRPLSRVNGWSPPLHSFQAISWITYLAMSIVTFGIFIPFLPYSWKYAANIVMGGVFIFHLIVHLIAITIDPADTNVRLKKDYTQPVPAFDRSKHTHVIQNQYCHLCEVTASKKAKHCSACNKCVSGFDHHCKWLNNCVGRRNYWFFFWSVASAAVGILGVMIILCYICIQYFVNPDELRTDPLYKEIISENTWLLFLSLWPVPVKTPIVLSIAVMALLLAIASFVMLGHLLIFHLYLITKNMSTFDYLMKTRFKKNLHPAEEKELPLQKKGDLPQEKSDNWAWPKSPPRVGSQKFPVSTLSPKSSVCFVASPPKICHSED |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 128-178 | DHHC | ||||
Sequence: QYCHLCEVTASKKAKHCSACNKCVSGFDHHCKWLNNCVGRRNYWFFFWSVA | ||||||
Region | 291-332 | Disordered | ||||
Sequence: ELPLQKKGDLPQEKSDNWAWPKSPPRVGSQKFPVSTLSPKSS |
Domain
The DHHC domain is required for palmitoyltransferase activity.
Sequence similarities
Belongs to the DHHC palmitoyltransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length347
- Mass (Da)39,660
- Last updated2006-09-05 v2
- Checksum1D2C92540424C697
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1Y7VP32 | A0A1Y7VP32_MOUSE | Zdhhc11 | 151 | ||
A0A1Y7VLH9 | A0A1Y7VLH9_MOUSE | Zdhhc11 | 323 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY668948 EMBL· GenBank· DDBJ | AAU89702.1 EMBL· GenBank· DDBJ | mRNA | ||
CT010471 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC116803 EMBL· GenBank· DDBJ | AAI16804.2 EMBL· GenBank· DDBJ | mRNA | ||
BC116807 EMBL· GenBank· DDBJ | AAI16808.2 EMBL· GenBank· DDBJ | mRNA |