Q14738 · 2A5D_HUMAN

  • Protein
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
  • Gene
    PPP2R5D
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentprotein phosphatase type 2A complex
Molecular Functionphosphoprotein phosphatase activity
Molecular Functionprotein phosphatase activator activity
Molecular Functionprotein phosphatase regulator activity
Biological Processnegative regulation of peptidyl-threonine phosphorylation
Biological Processnervous system development
Biological Processpositive regulation of protein dephosphorylation
Biological Processprotein dephosphorylation
Biological Processsignal transduction

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
  • Alternative names
    • PP2A B subunit isoform B'-delta
    • PP2A B subunit isoform B56-delta
    • PP2A B subunit isoform PR61-delta
    • PP2A B subunit isoform R5-delta

Gene names

    • Name
      PPP2R5D

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q14738
  • Secondary accessions
    • A8K3I9
    • B5BUA6
    • O00494
    • O00696
    • Q15171
    • Q5TC39

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Involvement in disease

Houge-Janssens syndrome 1 (HJS1)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    An autosomal dominant disorder characterized by global developmental delay, hypotonia, variably impaired intellectual development, poor speech, and dysmorphic facial features. Additional more variable features may include macrocephaly and seizures.
  • See also
    MIM:616355
Natural variants in HJS1
Variant IDPosition(s)ChangeDescription
VAR_073708198E>Kin HJS1; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A; dbSNP:rs863225082
VAR_074491200E>Kin HJS1; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A; dbSNP:rs863225079
VAR_073709201P>Rin HJS1; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A; dbSNP:rs876657383
VAR_074492207W>Rin HJS1; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A; dbSNP:rs869320691

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_06941453found in a patient with delayed psychomotor development, no speech and cataracts; no effect on binding to subunit PPP2CA; no effect on binding to subunit PPP2R1A; dbSNP:rs757369209
Natural variantVAR_073708198in HJS1; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A; dbSNP:rs863225082
Natural variantVAR_074491200in HJS1; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A; dbSNP:rs863225079
Natural variantVAR_073709201in HJS1; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A; dbSNP:rs876657383
Natural variantVAR_074492207in HJS1; decreases binding to subunit PPP2CA; decreases binding to subunit PPP2R1A; dbSNP:rs869320691

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 445 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00000714521-602UniProtSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Modified residue (large scale data)60PRIDEPhosphoserine
Modified residue (large scale data)62PRIDEPhosphoserine
Modified residue63UniProtPhosphothreonine
Modified residue (large scale data)63PRIDEPhosphothreonine
Modified residue (large scale data)75PRIDEPhosphoserine
Modified residue88UniProtPhosphoserine
Modified residue (large scale data)88PRIDEPhosphoserine
Modified residue89UniProtPhosphoserine
Modified residue (large scale data)89PRIDEPhosphoserine
Modified residue90UniProtPhosphoserine
Modified residue (large scale data)90PRIDEPhosphoserine
Modified residue (large scale data)95PRIDEPhosphoserine
Modified residue (large scale data)109PRIDEPhosphoserine
Modified residue (large scale data)461PRIDEPhosphothreonine
Modified residue (large scale data)533PRIDEPhosphoserine
Modified residue (large scale data)538PRIDEPhosphothreonine
Modified residue573UniProtPhosphoserine
Modified residue (large scale data)573PRIDEPhosphoserine
Modified residue (large scale data)580PRIDEPhosphotyrosine
Modified residue598UniProtPhosphoserine
Modified residue (large scale data)598PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.

Induction

By retinoic acid; in neuroblastoma cell lines.

Gene expression databases

Organism-specific databases

Interaction

Subunit

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with the PP2A A subunit PPP2R1A (PubMed:37761890).
Interacts with SGO1 (PubMed:16541025).
Interacts with ADCY8 (PubMed:22976297).

Binary interactions

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for compositional bias, region, repeat, motif.

TypeIDPosition(s)Description
Compositional bias1-15Basic and acidic residues
Region1-96Disordered
Repeat37-381
Region37-528 X 2 AA approximate tandem repeats of Q-P
Repeat39-402
Repeat41-423
Repeat43-444
Repeat45-465
Repeat47-486; approximate
Repeat49-507; approximate
Compositional bias50-74Polar residues
Repeat51-528
Compositional bias78-92Basic and acidic residues
Motif523-530SH3-binding; class I
Motif548-565Nuclear localization signal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q14738-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    Delta-1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    602
  • Mass (Da)
    69,992
  • Last updated
    1996-11-01 v1
  • Checksum
    F15F71AF4E565387
MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL

Q14738-2

  • Name
    Delta-2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q14738-3

  • Name
    Delta-3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0Y8C4H0Y8C4_HUMANPPP2R5D504
H7C5Z1H7C5Z1_HUMANPPP2R5D111
H7C5Q9H7C5Q9_HUMANPPP2R5D154
E9PFR3E9PFR3_HUMANPPP2R5D594

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias1-15Basic and acidic residues
Alternative sequenceVSP_00511011-116in isoform Delta-3
Compositional bias50-74Polar residues
Compositional bias78-92Basic and acidic residues
Alternative sequenceVSP_00511185-116in isoform Delta-2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L76702
EMBL· GenBank· DDBJ
AAB69751.1
EMBL· GenBank· DDBJ
mRNA
AB000634
EMBL· GenBank· DDBJ
BAA20381.1
EMBL· GenBank· DDBJ
mRNA
AB000635
EMBL· GenBank· DDBJ
BAA20382.1
EMBL· GenBank· DDBJ
mRNA
D78360
EMBL· GenBank· DDBJ
BAA11372.1
EMBL· GenBank· DDBJ
mRNA
AK290604
EMBL· GenBank· DDBJ
BAF83293.1
EMBL· GenBank· DDBJ
mRNA
AB451342
EMBL· GenBank· DDBJ
BAG70156.1
EMBL· GenBank· DDBJ
mRNA
AB451357
EMBL· GenBank· DDBJ
BAG70171.1
EMBL· GenBank· DDBJ
mRNA
AL136304
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471081
EMBL· GenBank· DDBJ
EAX04133.1
EMBL· GenBank· DDBJ
Genomic DNA
BC010692
EMBL· GenBank· DDBJ
AAH10692.1
EMBL· GenBank· DDBJ
mRNA
BC001095
EMBL· GenBank· DDBJ
AAH01095.1
EMBL· GenBank· DDBJ
mRNA
BC001175
EMBL· GenBank· DDBJ
AAH01175.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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