Q14689 · DIP2A_HUMAN
- ProteinDisco-interacting protein 2 homolog A
- GeneDIP2A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1571 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the de novo synthesis of acetyl-CoA in vitro (By similarity).
Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity).
Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002).
Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission (By similarity).
Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes (PubMed:20054002).
Catalytic activity
- acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | dendritic spine | |
Cellular Component | membrane | |
Cellular Component | mitochondrion | |
Cellular Component | plasma membrane | |
Molecular Function | acetate-CoA ligase activity | |
Biological Process | acetyl-CoA biosynthetic process | |
Biological Process | dendritic spine morphogenesis | |
Biological Process | negative regulation of gene expression | |
Biological Process | positive regulation of peptidyl-lysine acetylation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDisco-interacting protein 2 homolog A
- EC number
- Short namesDIP2 homolog A
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ14689
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_047372 | 191 | in dbSNP:rs7283507 | |||
Sequence: P → A | ||||||
Natural variant | VAR_047373 | 372 | in dbSNP:rs16979312 | |||
Sequence: S → N |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,595 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000079906 | 1-1571 | UniProt | Disco-interacting protein 2 homolog A | |||
Sequence: MADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIDLHSAPPDVTTGLVEHSYFERPQVASVRSVPRGCSGSMLETADGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGSETSVLRGEPLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTTGKAVYTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLKPGDRVALVFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGSQQVGFLLGSCGVFLALTTDACQKGLPKAQTGEVAAFKGWPPLSWLVIDGKHLAKPPKDWHPLAQDTGTGTAYIEYKTSKEGSTVGVTVSHASLLAQCRALTQACGYSEAETLTNVLDFKRDAGLWHGVLTSVMNRMHVVSVPYALMKANPLSWIQKVCFYKARAALVKSRDMHWSLLAQRGQRDVSLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSPEALTVAIRRPPDLGGPPPRKAVLSMNGLSYGVIRVDTEEKLSVLTVQDVGQVMPGANVCVVKLEGTPYLCKTDEVGEICVSSSATGTAYYGLLGITKNVFEAVPVTTGGAPIFDRPFTRTGLLGFIGPDNLVFIVGKLDGLMVTGVRRHNADDVVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLGGIHISETKQRFLEGTLHPCNVLMCPHTCVTNLPKPRQKQPEVGPASMIVGNLVAGKRIAQASGRELAHLEDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTATCVQLHKRAERVAAALMEKGRLSVGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSKSACVLTTQAVTRLLRSKEAAAAVDIRTWPTILDTDDIPKKKIASVFRPPSPDVLAYLDFSVSTTGILAGVKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTKGLGAQTGVLRMKGVNLSCVRTCMVVAEERPRIALTQSFSKLFKDLGLPARAVSTTFGCRVNVAICLQGTAGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYGEEALHADHFSARLSFGDTQTIWARTGYLGFLRRTELTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVELDGLEQDALDLVALVTNVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM | |||||||
Modified residue | 94 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 94 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 132 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 154 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 155 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 155 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 279 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Low expression in all tissues tested.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with FSTL1; DIP2A may act as a cell surface receptor for FSTL1 (PubMed:20054002, PubMed:20860622).
Interacts (via N-terminus) with CTTN (via SH3 domain); the interaction promotes acetylation of CTTN and is required for proper synaptic transmission (By similarity).
Interacts with SHANK3 (By similarity).
Interacts (via N-terminus) with CTTN (via SH3 domain); the interaction promotes acetylation of CTTN and is required for proper synaptic transmission (By similarity).
Interacts with SHANK3 (By similarity).
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-127 | DMAP1-binding | ||||
Sequence: EAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSS | ||||||
Region | 60-203 | Disordered | ||||
Sequence: LQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSASSTSSHPGGRPTTAPSAAATPGA | ||||||
Compositional bias | 64-82 | Polar residues | ||||
Sequence: NRIPGPSQTTAAAPKQQKS | ||||||
Compositional bias | 83-97 | Basic and acidic residues | ||||
Sequence: RPTASRDERFRSDVH | ||||||
Compositional bias | 123-140 | Polar residues | ||||
Sequence: LVHSSVETYTPPDTSSAS | ||||||
Compositional bias | 168-191 | Polar residues | ||||
Sequence: DRVIQGSSTSSSASSTSSHPGGRP | ||||||
Motif | 283-286 | PXXP motif; required for interaction with CTTN | ||||
Sequence: PKRP | ||||||
Region | 302-327 | Disordered | ||||
Sequence: VQQPDPNQPKPEGSETSVLRGEPLTA | ||||||
Motif | 307-310 | PXXP motif; required for interaction with CTTN | ||||
Sequence: PNQP |
Sequence similarities
Belongs to the DIP2 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 6 isoforms produced by Alternative splicing.
Q14689-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,571
- Mass (Da)170,369
- Last updated2003-07-11 v2
- Checksum40652BEFA5E9DD7C
Q14689-2
- Name2
- Differences from canonical
- 842-1571: Missing
Q14689-3
- Name3
Q14689-4
- Name4
Q14689-5
- Name5
- Differences from canonical
- 31-94: Missing
- 1167-1174: MSHAATSA → AGRGGSRL
- 1175-1571: Missing
Q14689-6
- Name6
- Differences from canonical
- 302-305: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A494C143 | A0A494C143_HUMAN | DIP2A | 1581 |
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_045408 | 31-94 | in isoform 5 | |||
Sequence: Missing | ||||||
Compositional bias | 64-82 | Polar residues | ||||
Sequence: NRIPGPSQTTAAAPKQQKS | ||||||
Compositional bias | 83-97 | Basic and acidic residues | ||||
Sequence: RPTASRDERFRSDVH | ||||||
Compositional bias | 123-140 | Polar residues | ||||
Sequence: LVHSSVETYTPPDTSSAS | ||||||
Compositional bias | 168-191 | Polar residues | ||||
Sequence: DRVIQGSSTSSSASSTSSHPGGRP | ||||||
Alternative sequence | VSP_007748 | 219-261 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_047246 | 302-305 | in isoform 6 | |||
Sequence: Missing | ||||||
Sequence conflict | 702 | in Ref. 3; BAG64412 | ||||
Sequence: V → F | ||||||
Alternative sequence | VSP_007749 | 842-1571 | in isoform 2 and isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_007750 | 880-889 | in isoform 4 | |||
Sequence: AIDSIHQVGV → VGAPARPMVR | ||||||
Alternative sequence | VSP_007751 | 890-1571 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_045409 | 1167-1174 | in isoform 5 | |||
Sequence: MSHAATSA → AGRGGSRL | ||||||
Alternative sequence | VSP_045410 | 1175-1571 | in isoform 5 | |||
Sequence: Missing | ||||||
Sequence conflict | 1541 | in Ref. 2; BAF69070 | ||||
Sequence: P → L |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF490768 EMBL· GenBank· DDBJ | AAM18046.1 EMBL· GenBank· DDBJ | mRNA | ||
AB273729 EMBL· GenBank· DDBJ | BAF69070.1 EMBL· GenBank· DDBJ | mRNA | ||
AK056738 EMBL· GenBank· DDBJ | BAB71268.1 EMBL· GenBank· DDBJ | mRNA | ||
AK303351 EMBL· GenBank· DDBJ | BAG64412.1 EMBL· GenBank· DDBJ | mRNA | ||
AP000337 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AP000338 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC033718 EMBL· GenBank· DDBJ | AAH33718.1 EMBL· GenBank· DDBJ | mRNA | ||
BC038443 EMBL· GenBank· DDBJ | AAH38443.1 EMBL· GenBank· DDBJ | mRNA | ||
D80006 EMBL· GenBank· DDBJ | BAA11501.1 EMBL· GenBank· DDBJ | mRNA |