Q14651 · PLSI_HUMAN

  • Protein
    Plastin-1
  • Gene
    PLS1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions.

Features

Showing features for binding site.

162950100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site24Ca2+ 1 (UniProtKB | ChEBI)
Binding site26Ca2+ 1 (UniProtKB | ChEBI)
Binding site28Ca2+ 1 (UniProtKB | ChEBI)
Binding site30Ca2+ 1 (UniProtKB | ChEBI)
Binding site35Ca2+ 1 (UniProtKB | ChEBI)
Binding site64Ca2+ 2 (UniProtKB | ChEBI)
Binding site66Ca2+ 2 (UniProtKB | ChEBI)
Binding site68Ca2+ 2 (UniProtKB | ChEBI)
Binding site70Ca2+ 2 (UniProtKB | ChEBI)
Binding site75Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactin filament
Cellular Componentactin filament bundle
Cellular Componentbrush border
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentextracellular exosome
Cellular Componentplasma membrane
Cellular Componentstereocilium
Cellular Componentterminal web
Molecular Functionactin filament binding
Molecular Functioncalcium ion binding
Molecular Functionstructural constituent of cytoskeleton
Biological Processactin filament bundle assembly
Biological Processactin filament network formation
Biological Processauditory receptor cell stereocilium organization
Biological Processintestinal D-glucose absorption
Biological Processpositive regulation of multicellular organism growth
Biological Processpositive regulation of protein localization to plasma membrane
Biological Processregulation of microvillus length
Biological Processterminal web assembly
Biological Processvestibular receptor cell stereocilium organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Plastin-1
  • Alternative names
    • Intestine-specific plastin (I-plastin)

Gene names

    • Name
      PLS1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q14651
  • Secondary accessions
    • A8K2Q1
    • D3DNG3
    • Q8NEG6

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Deafness, autosomal dominant, 76 (DFNA76)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A form of non-syndromic deafness characterized by mild to profound sensorineural hearing loss and variable age at onset. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • See also
    MIM:618787
Natural variants in DFNA76
Variant IDPosition(s)ChangeDescription
VAR_083821128F>Sin DFNA76
VAR_083822238L>Rin DFNA76
VAR_083823269E>Kin DFNA76
VAR_083824363L>Fin DFNA76

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_083821128in DFNA76
Natural variantVAR_048660146in dbSNP:rs35710125
Natural variantVAR_048661216in dbSNP:rs35435507
Natural variantVAR_083822238in DFNA76
Natural variantVAR_083823269in DFNA76
Natural variantVAR_083824363in DFNA76

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 663 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00000737501-629Plastin-1

Post-translational modification

Phosphorylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In small intestine, colon, and kidney; relatively lower levels of expression are detected in the lung and stomach.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain11-46EF-hand 1
Domain51-86EF-hand 2
Region108-380Actin-binding 1
Domain122-238Calponin-homology (CH) 1
Domain266-376Calponin-homology (CH) 2
Region381-625Actin-binding 2
Domain395-504Calponin-homology (CH) 3
Domain516-625Calponin-homology (CH) 4

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    629
  • Mass (Da)
    70,253
  • Last updated
    2009-03-03 v2
  • Checksum
    F904031933C2C323
MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILSVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLMGKGLNRIK

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
C9J359C9J359_HUMANPLS1119
C9J0F3C9J0F3_HUMANPLS1120
C9JYI1C9JYI1_HUMANPLS133
C9JU08C9JU08_HUMANPLS158
C9JVY2C9JVY2_HUMANPLS154
C9JAM3C9JAM3_HUMANPLS152
C9JAM8C9JAM8_HUMANPLS1266

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict317in Ref. 2; BAF83005
Sequence conflict441in Ref. 4; AAH31083
Sequence conflict487in Ref. 1; AAA19869

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L20826
EMBL· GenBank· DDBJ
AAA19869.1
EMBL· GenBank· DDBJ
mRNA
AK290316
EMBL· GenBank· DDBJ
BAF83005.1
EMBL· GenBank· DDBJ
mRNA
CH471052
EMBL· GenBank· DDBJ
EAW78965.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471052
EMBL· GenBank· DDBJ
EAW78967.1
EMBL· GenBank· DDBJ
Genomic DNA
BC031083
EMBL· GenBank· DDBJ
AAH31083.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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