Q14587 · ZN268_HUMAN
- ProteinZinc finger protein 268
- GeneZNF268
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids947 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Isoform 1
Isoform 2
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
The subsequence VLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLDPAQKCLYRSVMLENYSNLVSLGYQHTKPDIIFKLEQGEELC, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 268
- Alternative names
Gene names
- Community suggested namesZNF268
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ14587
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for mutagenesis, natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 85 | Strongly reduces nuclear localization and interaction with TRIM28; when associated with A-86. | ||||
Sequence: D → A | ||||||
Mutagenesis | 86 | Reduces nuclear localization. Strongly reduces nuclear localization and interaction with TRIM28; when associated with A-85. | ||||
Sequence: V → A | ||||||
Mutagenesis | 88 | Reduces nuclear localization. | ||||
Sequence: V → A | ||||||
Mutagenesis | 90 | Reduces nuclear localization. | ||||
Sequence: F → A | ||||||
Mutagenesis | 93 | Reduces nuclear localization. Strongly reduces nuclear localization; when associated with A-94 and A-95. | ||||
Sequence: E → A | ||||||
Mutagenesis | 94 | Reduces nuclear localization. Inhibits nuclear localization; when associated with A-93 and A-95. | ||||
Sequence: E → A | ||||||
Mutagenesis | 95 | Reduces nuclear localization. Inhibits nuclear localization; when associated with A-93 and A-94. | ||||
Sequence: W → A | ||||||
Natural variant | VAR_033562 | 175 | in dbSNP:rs7975069 | |||
Sequence: T → M |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,276 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000047495 | 1-947 | UniProt | Zinc finger protein 268 | |||
Sequence: MATRVRTASIWVPPLQERNSSWDRIRKLQGQESILGQGTPGLQPLPGTPRQKQKSRRIEKVLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLDPAQKCLYRSVMLENYSNLVSLGYQHTKPDIIFKLEQGEELCMVQAQVPNQTCPNTVWKIDDLMDWHQENKDKLGSTAKSFECTTFGKLCLLSTKYLSRQKPHKCGTHGKSLKYIDFTSDYARNNPNGFQVHGKSFFHSKHEQTVIGIKYCESIESGKTVNKKSQLMCQQMYMGEKPFGCSCCEKAFSSKSYLLVHQQTHAEEKPYGCNECGKDFSSKSYLIVHQRIHTGEKLHECSECRKTFSFHSQLVIHQRIHTGENPYECCECGKVFSRKDQLVSHQKTHSGQKPYVCNECGKAFGLKSQLIIHERIHTGEKPYECNECQKAFNTKSNLMVHQRTHTGEKPYVCSDCGKAFTFKSQLIVHQGIHTGVKPYGCIQCGKGFSLKSQLIVHQRSHTGMKPYVCNECGKAFRSKSYLIIHTRTHTGEKLHECNNCGKAFSFKSQLIIHQRIHTGENPYECHECGKAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLIIHQRTHTGEKPFECSECQKAFNTKSNLIVHQRTHTGEKPYSCNECGKAFTFKSQLIVHKGVHTGVKPYGCSQCAKTFSLKSQLIVHQRSHTGVKPYGCSECGKAFRSKSYLIIHMRTHTGEKPHECRECGKSFSFNSQLIVHQRIHTGENPYECSECGKAFNRKDQLISHQRTHAGEKPYGCSECGKAFSSKSYLIIHMRTHSGEKPYECNECGKAFIWKSLLIVHERTHAGVNPYKCSQCEKSFSGKLRLLVHQRMHTREKPYECSECGKAFIRNSQLIVHQRTHSGEKPYGCNECGKTFSQKSILSAHQRTHTGEKPCKCTECGKAFCWKSQLIMHQRTHVDDKH | |||||||
Modified residue (large scale data) | 48 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 747 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 752 | PRIDE | Phosphotyrosine | ||||
Sequence: Y |
Proteomic databases
PTM databases
Expression
Tissue specificity
Induction
Developmental stage
Gene expression databases
Organism-specific databases
Interaction
Subunit
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 81-152 | KRAB | ||||
Sequence: LSFMDVFVDFTWEEWQLLDPAQKCLYRSVMLENYSNLVSLGYQHTKPDIIFKLEQGEELCMVQAQVPNQTCP | ||||||
Zinc finger | 276-298 | C2H2-type 1 | ||||
Sequence: FGCSCCEKAFSSKSYLLVHQQTH | ||||||
Zinc finger | 304-326 | C2H2-type 2 | ||||
Sequence: YGCNECGKDFSSKSYLIVHQRIH | ||||||
Zinc finger | 332-354 | C2H2-type 3 | ||||
Sequence: HECSECRKTFSFHSQLVIHQRIH | ||||||
Zinc finger | 360-382 | C2H2-type 4 | ||||
Sequence: YECCECGKVFSRKDQLVSHQKTH | ||||||
Zinc finger | 388-410 | C2H2-type 5 | ||||
Sequence: YVCNECGKAFGLKSQLIIHERIH | ||||||
Zinc finger | 416-438 | C2H2-type 6 | ||||
Sequence: YECNECQKAFNTKSNLMVHQRTH | ||||||
Zinc finger | 444-466 | C2H2-type 7 | ||||
Sequence: YVCSDCGKAFTFKSQLIVHQGIH | ||||||
Zinc finger | 472-494 | C2H2-type 8 | ||||
Sequence: YGCIQCGKGFSLKSQLIVHQRSH | ||||||
Zinc finger | 500-522 | C2H2-type 9 | ||||
Sequence: YVCNECGKAFRSKSYLIIHTRTH | ||||||
Zinc finger | 528-550 | C2H2-type 10 | ||||
Sequence: HECNNCGKAFSFKSQLIIHQRIH | ||||||
Zinc finger | 556-578 | C2H2-type 11 | ||||
Sequence: YECHECGKAFSRKYQLISHQRTH | ||||||
Zinc finger | 584-606 | C2H2-type 12 | ||||
Sequence: YECTDCGKAFGLKSQLIIHQRTH | ||||||
Zinc finger | 612-634 | C2H2-type 13 | ||||
Sequence: FECSECQKAFNTKSNLIVHQRTH | ||||||
Zinc finger | 640-662 | C2H2-type 14 | ||||
Sequence: YSCNECGKAFTFKSQLIVHKGVH | ||||||
Zinc finger | 668-690 | C2H2-type 15 | ||||
Sequence: YGCSQCAKTFSLKSQLIVHQRSH | ||||||
Zinc finger | 696-718 | C2H2-type 16 | ||||
Sequence: YGCSECGKAFRSKSYLIIHMRTH | ||||||
Zinc finger | 724-746 | C2H2-type 17 | ||||
Sequence: HECRECGKSFSFNSQLIVHQRIH | ||||||
Zinc finger | 752-774 | C2H2-type 18 | ||||
Sequence: YECSECGKAFNRKDQLISHQRTH | ||||||
Zinc finger | 780-802 | C2H2-type 19 | ||||
Sequence: YGCSECGKAFSSKSYLIIHMRTH | ||||||
Zinc finger | 808-830 | C2H2-type 20 | ||||
Sequence: YECNECGKAFIWKSLLIVHERTH | ||||||
Zinc finger | 836-858 | C2H2-type 21 | ||||
Sequence: YKCSQCEKSFSGKLRLLVHQRMH | ||||||
Zinc finger | 864-886 | C2H2-type 22 | ||||
Sequence: YECSECGKAFIRNSQLIVHQRTH | ||||||
Zinc finger | 892-914 | C2H2-type 23 | ||||
Sequence: YGCNECGKTFSQKSILSAHQRTH | ||||||
Zinc finger | 920-942 | C2H2-type 24 | ||||
Sequence: CKCTECGKAFCWKSQLIMHQRTH |
Domain
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 7 isoforms produced by Alternative splicing.
Q14587-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsZNF268a, KW-4 variant-1
- Length947
- Mass (Da)108,374
- Last updated2001-08-29 v2
- ChecksumAC78F4824F4BE1A0
Q14587-2
- Name2
- SynonymsZNF268s, KW-4 variant-2
- Differences from canonical
- 1-161: Missing
Q14587-3
- Name3
- SynonymsZNF268c
Q14587-4
- Name4
- SynonymsZNF268d
Q14587-6
- Name5
- SynonymsZNF268e
Q14587-7
- Name6
- SynonymsZNF268f
Q14587-8
- Name7
- SynonymsZNF268g
Computationally mapped potential isoform sequences
There are 12 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A075B6T9 | A0A075B6T9_HUMAN | ZNF268 | 193 | ||
E7EV44 | E7EV44_HUMAN | ZNF268 | 188 | ||
K7EIF0 | K7EIF0_HUMAN | ZNF268 | 111 | ||
K7EMS6 | K7EMS6_HUMAN | ZNF268 | 94 | ||
K7EQP6 | K7EQP6_HUMAN | ZNF268 | 126 | ||
A0A087WV54 | A0A087WV54_HUMAN | ZNF268 | 121 | ||
F5H7L3 | F5H7L3_HUMAN | ZNF268 | 167 | ||
F5H6R9 | F5H6R9_HUMAN | ZNF268 | 38 | ||
F5H848 | F5H848_HUMAN | ZNF268 | 178 | ||
F5H670 | F5H670_HUMAN | ZNF268 | 100 | ||
F5H467 | F5H467_HUMAN | ZNF268 | 35 | ||
F5H1T2 | F5H1T2_HUMAN | ZNF268 | 68 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_053461 | 1-140 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_006909 | 1-161 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053464 | 12-44 | in isoform 6 | |||
Sequence: VPPLQERNSSWDRIRKLQGQESILGQGTPGLQP → GTNTPNLISSSSWNKEKSCVWCRPKFQIRPVQF | ||||||
Alternative sequence | VSP_053463 | 12-78 | in isoform 7 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053462 | 12-99 | in isoform 4 | |||
Sequence: VPPLQERNSSWDRIRKLQGQESILGQGTPGLQPLPGTPRQKQKSRRIEKVLEWLFISQEQPKITKSWGPLSFMDVFVDFTWEEWQLLD → GTNTPNLISSSSWNKEKSCVWCRPKFQIRPVQTQSGKLMILWIGIRKIKTSWEVWQKALNALHLENYVFLVQSIFQDKNLINVARMERV | ||||||
Alternative sequence | VSP_053465 | 45-947 | in isoform 6 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053466 | 79-135 | in isoform 5 | |||
Sequence: GPLSFMDVFVDFTWEEWQLLDPAQKCLYRSVMLENYSNLVSLGYQHTKPDIIFKLEQ → TQSGKLMILWIGIRKIKTSWEVRQKALNALHLENYVFLVQSIFQDKNLINVARMERV | ||||||
Alternative sequence | VSP_053467 | 100-947 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053468 | 136-947 | in isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053469 | 153-183 | in isoform 7 | |||
Sequence: NTVWKIDDLMDWHQENKDKLGSTAKSFECTT → ILKAGKSKAKVLAGLVSGEGPLCASKMTPCC | ||||||
Alternative sequence | VSP_053470 | 184-947 | in isoform 7 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_053471 | 222-947 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 323 | in Ref. 2; AAL99923 | ||||
Sequence: Q → P | ||||||
Sequence conflict | 335-336 | in Ref. 2; AAL99923 | ||||
Sequence: SE → IN | ||||||
Sequence conflict | 340 | in Ref. 2; AAL99923 | ||||
Sequence: T → A | ||||||
Sequence conflict | 344 | in Ref. 2; AAL99923 | ||||
Sequence: H → Q | ||||||
Sequence conflict | 363 | in Ref. 2; AAL99923 | ||||
Sequence: C → D | ||||||
Sequence conflict | 409 | in Ref. 2; AAL99923 | ||||
Sequence: I → T | ||||||
Sequence conflict | 860 | in Ref. 2; AAL99923 and 6; CAA55526 | ||||
Sequence: R → T |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF317549 EMBL· GenBank· DDBJ | AAG59817.1 EMBL· GenBank· DDBJ | mRNA | ||
AF385187 EMBL· GenBank· DDBJ | AAK69307.1 EMBL· GenBank· DDBJ | mRNA | ||
AF432217 EMBL· GenBank· DDBJ | AAL99923.1 EMBL· GenBank· DDBJ | mRNA | ||
AC026785 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
DQ057356 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
DQ057357 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
DQ057358 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
DQ057359 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
DQ057360 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
X78926 EMBL· GenBank· DDBJ | CAA55526.1 EMBL· GenBank· DDBJ | mRNA |