Q14192 · FHL2_HUMAN
- ProteinFour and a half LIM domains protein 2
- GeneFHL2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids279 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | focal adhesion | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | Z disc | |
Molecular Function | bHLH transcription factor binding | |
Molecular Function | identical protein binding | |
Molecular Function | metal ion binding | |
Molecular Function | transcription coregulator activity | |
Molecular Function | transcription corepressor activity | |
Molecular Function | transcription factor binding | |
Biological Process | atrial cardiac muscle cell development | |
Biological Process | heart trabecula formation | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | negative regulation of calcineurin-NFAT signaling cascade | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | osteoblast differentiation | |
Biological Process | response to hormone | |
Biological Process | ventricular cardiac muscle cell development |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFour and a half LIM domains protein 2
- Short namesFHL-2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ14192
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_067455 | 167 | ||||
Sequence: K → M |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 395 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), cross-link, modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000075737 | 1-279 | UniProt | Four and a half LIM domains protein 2 | |||
Sequence: MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI | |||||||
Modified residue (large scale data) | 74 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 78 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 167 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Cross-link | 220 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue | 238 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 255 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in skeletal muscle and heart.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with ZNF638 and TTN/titin (PubMed:11813260, PubMed:12432079).
Interacts with E4F1 (PubMed:16652157).
Interacts with GRB7 (PubMed:18853468).
Interacts with SIRT1 and FOXO1 (PubMed:15692560).
Interacts with CEFIP (PubMed:28717008).
Interacts with calcineurin (By similarity).
Interacts with FOXK1 (By similarity).
Interacts with E4F1 (PubMed:16652157).
Interacts with GRB7 (PubMed:18853468).
Interacts with SIRT1 and FOXO1 (PubMed:15692560).
Interacts with CEFIP (PubMed:28717008).
Interacts with calcineurin (By similarity).
Interacts with FOXK1 (By similarity).
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for zinc finger, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 7-31 | C4-type | ||||
Sequence: CHHCNESLFGKKYILREESPYCVVC | ||||||
Domain | 40-92 | LIM zinc-binding 1 | ||||
Sequence: CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDC | ||||||
Domain | 101-153 | LIM zinc-binding 2 | ||||
Sequence: CQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPC | ||||||
Domain | 162-212 | LIM zinc-binding 3 | ||||
Sequence: CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNC | ||||||
Domain | 221-275 | LIM zinc-binding 4 | ||||
Sequence: CAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDC |
Domain
The third LIM zinc-binding mediates interaction with E4F1.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q14192-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length279
- Mass (Da)32,193
- Last updated2006-10-17 v3
- ChecksumE94E3A7F6601F9F3
Q14192-2
- Name2
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_056999 | 53-151 | in isoform 2 | |||
Sequence: DLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCV → VPARWSTRAAAGMRPASSATAASSQLEPRVSSPKTIRISVCPAMRNNMPCSAFSAKSPSPREGSLTGSSPGTRSASCAPPAGSSCLGSASQLAMTLPTA | ||||||
Alternative sequence | VSP_057000 | 152-279 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L42176 EMBL· GenBank· DDBJ | AAA85333.1 EMBL· GenBank· DDBJ | mRNA | ||
U29332 EMBL· GenBank· DDBJ | AAC52073.1 EMBL· GenBank· DDBJ | mRNA | ||
AB038794 EMBL· GenBank· DDBJ | BAA92253.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB158503 EMBL· GenBank· DDBJ | BAD69710.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ307067 EMBL· GenBank· DDBJ | ABC25549.1 EMBL· GenBank· DDBJ | mRNA | ||
AC012360 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC068273 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC108058 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC014397 EMBL· GenBank· DDBJ | AAH14397.1 EMBL· GenBank· DDBJ | mRNA | ||
U60117 EMBL· GenBank· DDBJ | AAC50794.1 EMBL· GenBank· DDBJ | mRNA |