Q13948 · CASP_HUMAN
- ProteinProtein CASP
- GeneCUX1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids678 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | nucleoplasm | |
Biological Process | intra-Golgi vesicle-mediated transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein CASP
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ13948
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-619 | Cytoplasmic | ||||
Sequence: MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMART | ||||||
Transmembrane | 620-640 | Helical; Anchor for type IV membrane protein | ||||
Sequence: IGFFYTLFLHCLVFLVLYKLA | ||||||
Topological domain | 641-678 | Lumenal | ||||
Sequence: WSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_024923 | 464 | in dbSNP:rs803064 | |||
Sequence: A → T | ||||||
Natural variant | VAR_036285 | 490 | in a breast cancer sample; somatic mutation | |||
Sequence: S → G | ||||||
Natural variant | VAR_024924 | 545 | in dbSNP:rs2230103 | |||
Sequence: I → V | ||||||
Natural variant | VAR_036286 | 609 | in a colorectal cancer sample; somatic mutation; dbSNP:rs1287689842 | |||
Sequence: R → C | ||||||
Mutagenesis | 624 | Retained in the endoplasmic reticulum. | ||||
Sequence: Y → L | ||||||
Mutagenesis | 629 | No effect on subcellular location. | ||||
Sequence: H → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 804 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000071790 | 1-678 | UniProt | Protein CASP | |||
Sequence: MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ | |||||||
Modified residue (large scale data) | 562 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 564 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 584 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 586 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 594 | PRIDE | Phosphotyrosine | ||||
Sequence: Y |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 67-450 | |||||
Sequence: LLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLS | ||||||
Coiled coil | 502-556 | |||||
Sequence: LSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQS |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 11 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
Q13948-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name4
- SynonymsCASP
- Length678
- Mass (Da)77,455
- Last updated2006-01-10 v2
- ChecksumE587F222825EA47E
P39880-9
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name11
P39880-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name1
P39880-2
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name2
P39880-3
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name3
P39880-4
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name5
P39880-5
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name6
P39880-6
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name7
Q13948-2
- Name8
- Differences from canonical
- 288-289: Missing
Q13948-9
- Name9
Q13948-10
- Name10
- Differences from canonical
- 58-73: Missing
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P39880 | CUX1_HUMAN | CUX1 | 1505 | ||
A0A2R8Y8D0 | A0A2R8Y8D0_HUMAN | CUX1 | 117 | ||
A0A2R8Y852 | A0A2R8Y852_HUMAN | CUX1 | 1460 | ||
A0A2R8YDI1 | A0A2R8YDI1_HUMAN | CUX1 | 1358 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_045593 | 22-58 | in isoform 9 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_045927 | 58-73 | in isoform 10 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_040094 | 288-289 | in isoform 8 and isoform 9 | |||
Sequence: Missing | ||||||
Sequence conflict | 407 | in Ref. 6; AAH25422 | ||||
Sequence: N → S | ||||||
Sequence conflict | 455 | in Ref. 2; BAG64254 | ||||
Sequence: I → V | ||||||
Sequence conflict | 525 | in Ref. 2; BAG64254 | ||||
Sequence: L → V | ||||||
Sequence conflict | 551 | in Ref. 3; BAD96552 | ||||
Sequence: I → V | ||||||
Sequence conflict | 613 | in Ref. 2; BAG54140 | ||||
Sequence: S → P | ||||||
Sequence conflict | 657 | in Ref. 1; AAA35654 | ||||
Sequence: F → L |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L12579 EMBL· GenBank· DDBJ | AAA35654.1 EMBL· GenBank· DDBJ | mRNA | ||
AK125076 EMBL· GenBank· DDBJ | BAG54135.1 EMBL· GenBank· DDBJ | mRNA | ||
AK125097 EMBL· GenBank· DDBJ | BAG54140.1 EMBL· GenBank· DDBJ | mRNA | ||
AK303151 EMBL· GenBank· DDBJ | BAG64254.1 EMBL· GenBank· DDBJ | mRNA | ||
AK222832 EMBL· GenBank· DDBJ | BAD96552.1 EMBL· GenBank· DDBJ | mRNA | ||
AC005072 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC005086 EMBL· GenBank· DDBJ | AAP22331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC005088 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC005096 EMBL· GenBank· DDBJ | AAS07410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC005103 EMBL· GenBank· DDBJ | AAS07388.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC092788 EMBL· GenBank· DDBJ | AAS07523.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471197 EMBL· GenBank· DDBJ | EAW50227.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC025422 EMBL· GenBank· DDBJ | AAH25422.1 EMBL· GenBank· DDBJ | mRNA |