Q13948 · CASP_HUMAN

  • Protein
    Protein CASP
  • Gene
    CUX1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May be involved in intra-Golgi retrograde transport.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Cellular Componentnucleoplasm
Biological Processintra-Golgi vesicle-mediated transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein CASP

Gene names

    • Name
      CUX1
    • Synonyms
      CUTL1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q13948
  • Secondary accessions
    • B3KWH3
    • B3KWH8
    • B4DZZ2
    • G3V1Z6
    • J3KPQ6

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus membrane
; Single-pass type IV membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-619Cytoplasmic
Transmembrane620-640Helical; Anchor for type IV membrane protein
Topological domain641-678Lumenal

Keywords

Disease & Variants

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_024923464in dbSNP:rs803064
Natural variantVAR_036285490in a breast cancer sample; somatic mutation
Natural variantVAR_024924545in dbSNP:rs2230103
Natural variantVAR_036286609in a colorectal cancer sample; somatic mutation; dbSNP:rs1287689842
Mutagenesis624Retained in the endoplasmic reticulum.
Mutagenesis629No effect on subcellular location.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 804 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00000717901-678UniProtProtein CASP
Modified residue (large scale data)562PRIDEPhosphoserine
Modified residue (large scale data)564PRIDEPhosphoserine
Modified residue (large scale data)584PRIDEPhosphoserine
Modified residue586UniProtPhosphoserine
Modified residue (large scale data)594PRIDEPhosphotyrosine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homodimer; disulfide-linked. Interacts with GOLGA5.

Protein-protein interaction databases

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil67-450
Coiled coil502-556

Sequence similarities

Belongs to the CASP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

  • Sequence status
    Complete

This entry describes 11 isoforms produced by Alternative splicing. Additional isoforms seem to exist.

Q13948-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    4
  • Synonyms
    CASP
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    678
  • Mass (Da)
    77,455
  • Last updated
    2006-01-10 v2
  • Checksum
    E587F222825EA47E
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNIKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ

P39880-9

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

P39880-1

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

P39880-2

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

P39880-3

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

P39880-4

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

P39880-5

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

P39880-6

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

Q13948-2

  • Name
    8
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q13948-9

  • Name
    9
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q13948-10

  • Name
    10
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P39880CUX1_HUMANCUX11505
A0A2R8Y8D0A0A2R8Y8D0_HUMANCUX1117
A0A2R8Y852A0A2R8Y852_HUMANCUX11460
A0A2R8YDI1A0A2R8YDI1_HUMANCUX11358

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_04559322-58in isoform 9
Alternative sequenceVSP_04592758-73in isoform 10
Alternative sequenceVSP_040094288-289in isoform 8 and isoform 9
Sequence conflict407in Ref. 6; AAH25422
Sequence conflict455in Ref. 2; BAG64254
Sequence conflict525in Ref. 2; BAG64254
Sequence conflict551in Ref. 3; BAD96552
Sequence conflict613in Ref. 2; BAG54140
Sequence conflict657in Ref. 1; AAA35654

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L12579
EMBL· GenBank· DDBJ
AAA35654.1
EMBL· GenBank· DDBJ
mRNA
AK125076
EMBL· GenBank· DDBJ
BAG54135.1
EMBL· GenBank· DDBJ
mRNA
AK125097
EMBL· GenBank· DDBJ
BAG54140.1
EMBL· GenBank· DDBJ
mRNA
AK303151
EMBL· GenBank· DDBJ
BAG64254.1
EMBL· GenBank· DDBJ
mRNA
AK222832
EMBL· GenBank· DDBJ
BAD96552.1
EMBL· GenBank· DDBJ
mRNA
AC005072
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC005086
EMBL· GenBank· DDBJ
AAP22331.1
EMBL· GenBank· DDBJ
Genomic DNA
AC005088
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC005096
EMBL· GenBank· DDBJ
AAS07410.1
EMBL· GenBank· DDBJ
Genomic DNA
AC005103
EMBL· GenBank· DDBJ
AAS07388.1
EMBL· GenBank· DDBJ
Genomic DNA
AC092788
EMBL· GenBank· DDBJ
AAS07523.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471197
EMBL· GenBank· DDBJ
EAW50227.1
EMBL· GenBank· DDBJ
Genomic DNA
BC025422
EMBL· GenBank· DDBJ
AAH25422.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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