The Schizosaccharomyces pombe rad3 checkpoint gene.Bentley N.J., Holtzman D.A., Flaggs G., Keegan K.S., DeMaggio A., Ford J.C., Hoekstra M., Carr A.M.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO J. 15:6641-6651 (1996)Cited in2
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.Cimprich K.A., Shin T.B., Keith C.T., Schreiber S.L.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITYTissueT-cellCategoriesSequences, ExpressionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 93:2850-2855 (1996)Cited in1
Evidence for alternate splicing within the mRNA transcript encoding the DNA damage response kinase ATR.Mannino J.L., Kim W.-J., Wernick M., Nguyen S.V., Braquet R., Adamson A.W., Den Z., Batzer M.A., Collins C.C., Brown K.D.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 433-526 (ISOFORMS 1 AND 2), TISSUE SPECIFICITYCategoriesSequences, ExpressionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGene 272:35-43 (2001)Cited in1
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.Keegan K.S., Holtzman D.A., Plug A.W., Christenson E.R., Brainerd E.E., Flaggs G., Bentley N.J., Taylor E.M., Meyn M.S.[...], Hoekstra M.F.View abstractCited forSUBCELLULAR LOCATION, TISSUE SPECIFICITYCategoriesExpression, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenes Dev. 10:2423-2437 (1996)Cited in2Mapped to40
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.Sarkaria J.N., Tibbetts R.S., Busby E.C., Kennedy A.P., Hill D.E., Abraham R.T.View abstractCited forACTIVITY REGULATIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCancer Res. 58:4375-4382 (1998)Cited in3
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA- damaging agents and defects in cell cycle checkpoints.Cliby W.A., Roberts C.J., Cimprich K.A., Stringer C.M., Lamb J.R., Schreiber S.L., Friend S.H.View abstractCited forFUNCTION, AUTOPHOSPHORYLATION, MUTAGENESIS OF ASP-2475CategoriesFunction, PTM / Processing, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO J. 17:159-169 (1998)Cited in1
Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.Wright J.A., Keegan K.S., Herendeen D.R., Bentley N.J., Carr A.M., Hoekstra M.F., Concannon P.View abstractCited forFUNCTION, MUTAGENESIS OF ASP-2494CategoriesFunction, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 95:7445-7450 (1998)Cited in1
Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4.Schmidt D.R., Schreiber S.L.View abstractCited forINTERACTION WITH HDAC2, IDENTIFICATION IN A COMPLEX CONTAINING HDAC2 AND CHD4CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochemistry 38:14711-14717 (1999)Cited in3
A role for ATR in the DNA damage-induced phosphorylation of p53.Tibbetts R.S., Brumbaugh K.M., Williams J.M., Sarkaria J.N., Cliby W.A., Shieh S.-Y., Taya Y., Prives C., Abraham R.T.View abstractCited forFUNCTION, MUTAGENESIS OF LYS-2327 AND ASP-2475CategoriesFunction, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenes Dev. 13:152-157 (1999)Cited in1Mapped to32
Substrate specificities and identification of putative substrates of ATM kinase family members.Kim S.-T., Lim D.-S., Canman C.E., Kastan M.B.View abstractCited forCOFACTOR, FUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 274:37538-37543 (1999)Cited in1Mapped to9
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.Hall-Jackson C.A., Cross D.A.E., Morrice N., Smythe C.View abstractCited forFUNCTION, AUTOPHOSPHORYLATION, MUTAGENESIS OF ASP-2494, ACTIVITY REGULATIONCategoriesFunction, PTM / Processing, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCOncogene 18:6707-6713 (1999)Cited in1Mapped to1
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.Tibbetts R.S., Cortez D., Brumbaugh K.M., Scully R., Livingston D., Elledge S.J., Abraham R.T.View abstractCited forFUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-2327CategoriesFunction, Disease & Variants, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenes Dev. 14:2989-3002 (2000)Cited in2Mapped to37
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.Ward I.M., Chen J.View abstractCited forFUNCTION, SUBCELLULAR LOCATIONCategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 276:47759-47762 (2001)Cited in3Mapped to27
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.Bao S., Tibbetts R.S., Brumbaugh K.M., Fang Y., Richardson D.A., Ali A., Chen S.M., Abraham R.T., Wang X.-F.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 411:969-974 (2001)Cited in3
ATR and ATRIP: partners in checkpoint signaling.Cortez D., Guntuku S., Qin J., Elledge S.J.View abstractCited forFUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ATRIPCategoriesFunction, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 294:1713-1716 (2001)Cited in2Mapped to14
ATR regulates fragile site stability.Casper A.M., Nghiem P., Arlt M.F., Glover T.W.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 111:779-789 (2002)Cited in1
Preferential binding of ATR protein to UV-damaged DNA.Uensal-Kacmaz K., Makhov A.M., Griffith J.D., Sancar A.View abstractCited forDNA-BINDING, MUTAGENESIS OF LYS-2327CategoriesFunction, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 99:6673-6678 (2002)Cited in1
ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation.Barr S.M., Leung C.G., Chang E.E., Cimprich K.A.View abstractCited forFUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ASP-2475CategoriesFunction, Disease & Variants, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCurr. Biol. 13:1047-1051 (2003)Cited in2
Human claspin is required for replication checkpoint control.Chini C.C.S., Chen J.View abstractCited forINTERACTION WITH CLSPNCategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 278:30057-30062 (2003)Cited in3Mapped to2
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation.Wang Y., Qin J.View abstractCited forFUNCTION, INTERACTION WITH MSH2, IDENTIFICATION BY MASS SPECTROMETRYCategoriesFunction, Sequences, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 100:15387-15392 (2003)Cited in4Mapped to22
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.Zou L., Elledge S.J.View abstractCited forFUNCTION, DNA-BINDING, IDENTIFICATION IN A COMPLEX WITH RPA AND ATRIPCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 300:1542-1548 (2003)Cited in4Mapped to21
BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint.Dierov J., Dierova R., Carroll M.View abstractCited forINTERACTION WITH BCR-ABLCategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCancer Cell 5:275-285 (2004)Cited in1
UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress.Ward I.M., Minn K., Chen J.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 279:9677-9680 (2004)Cited in1
Recruitment of the cell cycle checkpoint kinase ATR to chromatin during S- phase.Dart D.A., Adams K.E., Akerman I., Lakin N.D.View abstractCited forDNA-BINDING, SUBCELLULAR LOCATIONCategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 279:16433-16440 (2004)Cited in1Mapped to8
ATR couples FANCD2 monoubiquitination to the DNA-damage response.Andreassen P.R., D'Andrea A.D., Taniguchi T.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenes Dev. 18:1958-1963 (2004)Cited in2