Q13478 · IL18R_HUMAN

  • Protein
    Interleukin-18 receptor 1
  • Gene
    IL18R1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:14528293, PubMed:25261253, PubMed:25500532, PubMed:37993714, PubMed:8626725).
Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).
Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).

Catalytic activity

Features

Showing features for active site.

154150100150200250300350400450500
TypeIDPosition(s)Description
Active site455

GO annotations

AspectTerm
Cellular Componentinterleukin-18 receptor complex
Cellular Componentplasma membrane
Molecular Functioninterleukin-1 receptor activity
Molecular Functioninterleukin-18 binding
Molecular Functioninterleukin-18 receptor activity
Molecular FunctionNAD+ nucleosidase activity
Molecular FunctionNAD+ nucleotidase, cyclic ADP-ribose generating
Molecular Functionsignaling receptor activity
Biological Processimmune response
Biological Processinflammatory response
Biological Processinterleukin-18-mediated signaling pathway
Biological Processnatural killer cell activation
Biological Processnegative regulation of cold-induced thermogenesis
Biological Processpositive regulation of NF-kappaB transcription factor activity
Biological Processpositive regulation of non-canonical NF-kappaB signal transduction
Biological Processpositive regulation of T-helper 1 cell cytokine production
Biological Processpositive regulation of type II interferon production
Biological Processsignal transduction
Biological ProcessT-helper 1 cell differentiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Interleukin-18 receptor 1
  • EC number
  • Short names
    IL-18R-1; IL-18R1
  • Alternative names
    • CD218 antigen-like family member A
    • CDw218a
    • IL1 receptor-related protein (IL-1Rrp; IL1R-rp)
    • Interleukin-18 receptor alpha
      (IL-18R-alpha; IL-18Ralpha
      )
  • CD Antigen Name
    • CD218a

Gene names

    • Name
      IL18R1
    • Synonyms
      IL1RRP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q13478
  • Secondary accessions
    • B2R9Y5
    • Q52LC9

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain22-329Extracellular
Transmembrane330-350Helical
Topological domain351-541Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_053379210in dbSNP:rs11465635
Natural variantVAR_053380232in dbSNP:rs11465644
Mutagenesis297Decreases the affinity for IL18 suggesting that the N-linked glycosylation contributes to ligand recognition.
Natural variantVAR_053381310in dbSNP:rs11465648
Natural variantVAR_014955317
Natural variantVAR_053382423in dbSNP:rs12619169

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 699 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000001544819-541Interleukin-18 receptor 1
Disulfide bond22↔41
Disulfide bond43↔81
Glycosylation91N-linked (GlcNAc...) asparagine
Glycosylation102N-linked (GlcNAc...) asparagine
Disulfide bond119↔158
Disulfide bond140↔185
Glycosylation150N-linked (GlcNAc...) asparagine
Glycosylation197N-linked (GlcNAc...) asparagine
Glycosylation203N-linked (GlcNAc...) asparagine
Glycosylation236N-linked (GlcNAc...) asparagine
Disulfide bond237↔298
Glycosylation255N-linked (GlcNAc...) asparagine
Glycosylation297N-linked (GlcNAc...) asparagine

Post-translational modification

N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10653850, PubMed:10925275, PubMed:11046021).

Induction

Induced by IL12/interleukin-12 in T-cells. Proposed to be a phenotypic marker for T-helper 1 (Th1) cells.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Forms a ternary complex with IL18 and IL18RAP (PubMed:14528293, PubMed:25500532).
Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable). Interacts with SLC12A3 in peritoneal macrophages; this interaction is increased by IL18 treatment (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q13478IL18 Q141162EBI-9817499, EBI-3910835

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain33-121Ig-like C2-type 1
Domain133-212Ig-like C2-type 2
Domain220-312Ig-like C2-type 3
Domain373-520TIR

Domain

The TIR domain mediates NAD+ hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

Sequence similarities

Belongs to the interleukin-1 receptor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    541
  • Mass (Da)
    62,304
  • Last updated
    1996-11-01 v1
  • Checksum
    7173DB9C7EA71D32
MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSES

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q86YL8Q86YL8_HUMANIL18R1170

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U43672
EMBL· GenBank· DDBJ
AAC50390.1
EMBL· GenBank· DDBJ
mRNA
AK313967
EMBL· GenBank· DDBJ
BAG36682.1
EMBL· GenBank· DDBJ
mRNA
AC007248
EMBL· GenBank· DDBJ
AAY15048.1
EMBL· GenBank· DDBJ
Genomic DNA
BC069575
EMBL· GenBank· DDBJ
AAH69575.1
EMBL· GenBank· DDBJ
mRNA
BC093975
EMBL· GenBank· DDBJ
AAH93975.1
EMBL· GenBank· DDBJ
mRNA
BC093977
EMBL· GenBank· DDBJ
AAH93977.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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