Q12XM2 · Q12XM2_METBU
- ProteinNAD kinase
- GenenadK
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids278 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Catalytic activity
- NAD+ + ATP = ADP + NADP+ + H+
Cofactor
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 71 | Proton acceptor | |||
Binding site | 71-72 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 76 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 139-140 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 150 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 167 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 169 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 180-185 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 204 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 239 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | NAD+ kinase activity | |
Biological Process | NAD metabolic process | |
Biological Process | NADP biosynthetic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD kinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanococcoides
Accessions
- Primary accessionQ12XM2
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length278
- Mass (Da)29,820
- Last updated2006-08-22 v1
- MD5 Checksum8C460CFFD12A45A40E8AE7C3D49CE6A6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000300 EMBL· GenBank· DDBJ | ABE51804.1 EMBL· GenBank· DDBJ | Genomic DNA |