Q12WR3 · RLME_METBU
- ProteinRibosomal RNA large subunit methyltransferase E
- GenerlmE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids267 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Catalytic activity
- uridine2552 in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyluridine2552 in 23S rRNA + S-adenosyl-L-homocysteine + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 50 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 52 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 68 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 84 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 109 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Active site | 149 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | rRNA (uridine-2'-O-)-methyltransferase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibosomal RNA large subunit methyltransferase E
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanococcoides
Accessions
- Primary accessionQ12WR3
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000282818 | 1-267 | Ribosomal RNA large subunit methyltransferase E | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 196-255 | TRAM | |||
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length267
- Mass (Da)30,042
- Last updated2006-08-22 v1
- Checksum2727DE1603380550
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000300 EMBL· GenBank· DDBJ | ABE52113.1 EMBL· GenBank· DDBJ | Genomic DNA |