Q12UK3 · FAEHP_METBU

Function

function

Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H4MPT) to 5,10-methylenetetrahydromethanopterin.
Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.

Catalytic activity

Pathway

Carbohydrate biosynthesis; D-ribose 5-phosphate biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site17Proton donor
Binding site19substrate
Binding site48substrate
Binding site66substrate
Binding site68substrate
Binding site83substrate

GO annotations

AspectTerm
Molecular Function3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Molecular Functioncarbon-nitrogen lyase activity
Molecular Functionhexulose-6-phosphate synthase activity
Molecular Functionhydro-lyase activity
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processcarbohydrate biosynthetic process
Biological ProcessL-ascorbic acid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional enzyme Fae/Hps

Including 2 domains:

  • Recommended name
    5,6,7,8-tetrahydromethanopterin hydro-lyase
  • EC number
  • Alternative names
    • Formaldehyde-activating enzyme
      (Fae
      )
  • Recommended name
    3-hexulose-6-phosphate synthase
  • EC number
  • Short names
    HPS
  • Alternative names
    • D-arabino-3-hexulose-6-phosphate formaldehyde lyase

Gene names

    • Name
      fae-hps
    • Ordered locus names
      Mbur_1994

Organism names

Accessions

  • Primary accession
    Q12UK3

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000673231-396Bifunctional enzyme Fae/Hps

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-161Formaldehyde-activating enzyme
Region162-3963-hexulose-6-phosphate synthase

Sequence similarities

In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    396
  • Mass (Da)
    42,461
  • Last updated
    2006-08-22 v1
  • Checksum
    4EC2C5C1A4D2AB6B
MMLIGEALIGEAPELAHVDLMIGDKEGPVGQAFATGMTQLSAGHTPVLSVIRPNLPTKPSTLIVPKVTVKGMDQASQIFGPAQAAVSKAVADAVEEGLIPKEKAEDLVIIASVFIHPQAVDYNRIYRYNYGATKLALKRALDGFPDIDTVLHEKDRAAHAVMGFKISKLWDAPYLQVALDNPNLPVILNIIKQLPKSDHLILEAGTPLIKRYGVDVISKIREVRPDAFIVADLKTLDTGNLEARMVADATADAIVVSALAPIATLNKVIEEAHKTGIYAVMDTLNTPDPVAVLEQLDVLPDVVELHRAIDIEGTAHAWGSIEGIKALAVKRSSKVLVAVAGGVRVDTISDALGAGADILVVGRAITNSKDVRQAADRFIEGLNKPEIDQFRIMTDF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000300
EMBL· GenBank· DDBJ
ABE52873.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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