Q12UK3 · FAEHP_METBU
- ProteinBifunctional enzyme Fae/Hps
- Genefae-hps
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids396 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H4MPT) to 5,10-methylenetetrahydromethanopterin.
Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
Catalytic activity
- 5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O
Pathway
Carbohydrate biosynthesis; D-ribose 5-phosphate biosynthesis.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 17 | Proton donor | |||
Binding site | 19 | substrate | |||
Binding site | 48 | substrate | |||
Binding site | 66 | substrate | |||
Binding site | 68 | substrate | |||
Binding site | 83 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-dehydro-L-gulonate-6-phosphate decarboxylase activity | |
Molecular Function | carbon-nitrogen lyase activity | |
Molecular Function | hexulose-6-phosphate synthase activity | |
Molecular Function | hydro-lyase activity | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | carbohydrate biosynthetic process | |
Biological Process | L-ascorbic acid catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional enzyme Fae/Hps
Including 2 domains:
- Recommended name5,6,7,8-tetrahydromethanopterin hydro-lyase
- EC number
- Alternative names
- Recommended name3-hexulose-6-phosphate synthase
- EC number
- Short namesHPS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanococcoides
Accessions
- Primary accessionQ12UK3
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000067323 | 1-396 | Bifunctional enzyme Fae/Hps | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-161 | Formaldehyde-activating enzyme | |||
Region | 162-396 | 3-hexulose-6-phosphate synthase | |||
Sequence similarities
In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length396
- Mass (Da)42,461
- Last updated2006-08-22 v1
- Checksum4EC2C5C1A4D2AB6B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000300 EMBL· GenBank· DDBJ | ABE52873.1 EMBL· GenBank· DDBJ | Genomic DNA |