Q12IW9 · NTPPA_SHEDO
- ProteindTTP/UTP pyrophosphatase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids198 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Catalytic activity
- dTTP + H2O = diphosphate + dTMP + H+
Cofactor
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 11 | Important for substrate specificity | ||||
Sequence: R | ||||||
Active site | 76 | Proton acceptor | ||||
Sequence: D | ||||||
Site | 77 | Important for substrate specificity | ||||
Sequence: T | ||||||
Site | 159 | Important for substrate specificity | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dTTP diphosphatase activity | |
Molecular Function | UTP diphosphatase activity | |
Biological Process | nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namedTTP/UTP pyrophosphatase
- EC number
- Short namesdTTPase/UTPase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionQ12IW9
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000267424 | 1-198 | dTTP/UTP pyrophosphatase | |||
Sequence: MTWVLASSSPRRKELLAQAGFTQAQFQFVQVSPDIDESQLALETPSAYVTRLALEKAQAGLALSRHLPHPKVIGSDTIVVLDGQLLGKPTDPQDAERMLTSLSGRTHTVMTAVAITNGKRALSRLCQTQVSFTSLSQQDIAKYVATGEPMDKAGAYGIQGLGGCFVSEISGSYSSVVGLPLVETRALLAAMMEQDDTL |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length198
- Mass (Da)21,139
- Last updated2006-08-22 v1
- ChecksumBAE09666369258D9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000302 EMBL· GenBank· DDBJ | ABE56607.1 EMBL· GenBank· DDBJ | Genomic DNA |