Q12IW9 · NTPPA_SHEDO

Function

function

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for site, active site.

TypeIDPosition(s)Description
Site11Important for substrate specificity
Active site76Proton acceptor
Site77Important for substrate specificity
Site159Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondTTP diphosphatase activity
Molecular FunctionUTP diphosphatase activity
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dTTP/UTP pyrophosphatase
  • EC number
  • Short names
    dTTPase/UTPase
  • Alternative names
    • Nucleoside triphosphate pyrophosphatase
    • Nucleotide pyrophosphatase
      (Nucleotide PPase
      )

Gene names

    • Ordered locus names
      Sden_3331

Organism names

Accessions

  • Primary accession
    Q12IW9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002674241-198dTTP/UTP pyrophosphatase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the Maf family. YhdE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    21,139
  • Last updated
    2006-08-22 v1
  • Checksum
    BAE09666369258D9
MTWVLASSSPRRKELLAQAGFTQAQFQFVQVSPDIDESQLALETPSAYVTRLALEKAQAGLALSRHLPHPKVIGSDTIVVLDGQLLGKPTDPQDAERMLTSLSGRTHTVMTAVAITNGKRALSRLCQTQVSFTSLSQQDIAKYVATGEPMDKAGAYGIQGLGGCFVSEISGSYSSVVGLPLVETRALLAAMMEQDDTL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000302
EMBL· GenBank· DDBJ
ABE56607.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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