Q12C49 · Q12C49_POLSJ

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site835-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1085-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site135-1435-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site198uracil (UniProtKB | ChEBI)
Binding site203-205uracil (UniProtKB | ChEBI)
Binding site2045-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • Ordered locus names
      Bpro_1963

Organism names

Accessions

  • Primary accession
    Q12C49

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    213
  • Mass (Da)
    23,670
  • Last updated
    2006-08-22 v1
  • Checksum
    BA8700FB78362910
MTTRNDKVHVIDHPLVQHKLTLMRRKDASTNTFRTLLNELSMLMAYEVTRDMPMQEIEIETPLETTTSRVIDGKKLVFVSILRAGNGILEGMLSVVPGARVGHVGLYRDPKTLTAVEYYFKMPHDMQERDVVIVDPMLATGNSAIAAVDRLKELNPKSIKFVCLLTCPEGIAALQKAHPDVAIYTAAIDRQLNDHGYILPGLGDAGDRIFGTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000316
EMBL· GenBank· DDBJ
ABE43893.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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