Q12751 · RTP1_YEAST

Function

function

Required for the cytoplasmic assembly and the nuclear import of RNA polymerase II. May facilitate the starting interaction between RNA polymerase II subunits RPB2 and RPB3 and the subsequent interaction of the resulting complex with subunit RPB1. May also participate in the transport of RNA polymerase II through the nuclear pore complex.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Biological Processprotein import into nucleus
Biological Processprotein secretion

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA polymerase II assembly factor RTP1
  • Alternative names
    • Required for nuclear transport of RNA pol II protein 1
    • Transport and Golgi organization protein 6 homolog

Gene names

    • Name
      RTP1
    • ORF names
      YM8010.15
    • Ordered locus names
      YMR185W

Organism names

Accessions

  • Primary accession
    Q12751
  • Secondary accessions
    • D6W009

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002033221-981RNA polymerase II assembly factor RTP1

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with RNA polymerase II subunits RPB2 and RPB3. Interacts with the R2TP complex. Interacts with the nuclear pore complex subunits NUP100 and NUP116.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat, compositional bias, region.

TypeIDPosition(s)Description
Repeat64-101HEAT 1
Repeat161-199HEAT 2
Repeat226-261HEAT 3
Repeat366-403HEAT 4
Repeat609-646HEAT 5
Compositional bias630-650Acidic residues
Region630-652Disordered
Repeat655-692HEAT 6
Repeat765-799HEAT 7
Repeat800-836HEAT 8
Repeat945-980HEAT 9

Sequence similarities

Belongs to the Tango6 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    981
  • Mass (Da)
    113,249
  • Last updated
    1997-11-01 v1
  • Checksum
    13F29F65C6D4E53B
MNEDKEQKINIHDILNTRPKLTKKTALDVFFEDLDDNVITPINEYVLDSGSSSSSSIYQALKCSNNNEFVAVLLQKFQNLHIHVLEQQRRLIESKSDLLPISLHDMKYVDELINLLIIHGIDANLSPTMKIPFDSKRINTFKKGQKSAEYETPRWHTINNDTLSQVITVFYNVLTSERSSDYLREIISKGSAYANILLGLIVLHLQLPNRYSSQMITNLEDTQETYTLFGVYTLLVETIQDEKVREPILSKLTTLTLRRPENGLISLIDFVLGVRDAEDIDIEKFNRIYQILMSKPKTMTNLQYLTELFKQIYDGLTFVNRPILVTCLNGLILKFYLRNKRIVNDFLFKKVRSIIFNSPLTDHTAKELNDVINVLISLSKNSSSDLLNDLVTSCPDEDGTTPGQFFLYVWIYALFLKKNQKLDPLEINKLSISDNKSTDSIHFPEQSSSKYYEVVLSLLKSLIVITENFQYLNVLSLNLLNFEHEKWKYLIDLDTQLPYISVKNTDMAELFFEKGSKNSQISEFLQDMDLSIELFMEFLVLLNDEEQSKTLFLDILKRWVHHTKKSEKRSSDNHSGMPSVTDNALILMDLKLLECMNNRFKTKIVNKPKDVLIVIDQLIDVVQEKDETIQEVEADSDDEVEEGEETEELDPNENSSYKIILQLLSTVLSESSSSILLQNSYILKSISRKLQSFNTNASEIDALLASIDNILINGHTTERNDNIEIEMDEERLDKAITSLHDPLVPIKSYGLTELRHLAEKKSPVISLEKVLQIHLDYLKNMDPFIYLNVIKGLTTLCELEPETILPLLAEFYANKKKKNRLDDVLKVGEVFINYIQRQNELFQGKLAYLIIDTCLSIVRPNDSKPLDNRWRMSSMSILGMCLQINARGVSDRIRDMLDCVFGILQLEQPQNHLKDKDDSFLMRRSAVHLIHDLLYSTGFDLLPFEYNYDKLKTLLSYVRDQDEDYMVCEQIDKLLTVLDSL

Sequence caution

The sequence AAA87904.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias630-650Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z49808
EMBL· GenBank· DDBJ
CAA89918.1
EMBL· GenBank· DDBJ
Genomic DNA
U20349
EMBL· GenBank· DDBJ
AAA87904.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
BK006946
EMBL· GenBank· DDBJ
DAA10083.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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