Q12563 · MNS1B_ASPPH

Function

function

Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Ca2+. Can also use Mg2+, but with lower efficiency.

Pathway

Protein modification; protein glycosylation.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site377Proton donor
Binding site503Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasmic vesicle lumen
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular Functionmannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Biological Processcarbohydrate metabolic process
Biological ProcessERAD pathway
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Mannosyl-oligosaccharide alpha-1,2-mannosidase 1B
  • EC number
  • Alternative names
    • Class I alpha-mannosidase 1B
    • Man(9)-alpha-mannosidase 1B

Gene names

    • Name
      mns1B
    • Synonyms
      msdS

Organism names

Accessions

  • Primary accession
    Q12563

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000039482122-513Mannosyl-oligosaccharide alpha-1,2-mannosidase 1B
Glycosylation97N-linked (GlcNAc...) asparagine
Glycosylation117N-linked (GlcNAc...) asparagine
Glycosylation150N-linked (GlcNAc...) asparagine
Glycosylation184N-linked (GlcNAc...) asparagine
Glycosylation251N-linked (GlcNAc...) asparagine
Glycosylation322N-linked (GlcNAc...) asparagine
Disulfide bond334↔363
Glycosylation348N-linked (GlcNAc...) asparagine
Glycosylation368N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Interaction

Subunit

Monomer.

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyl hydrolase 47 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    513
  • Mass (Da)
    55,875
  • Last updated
    1996-11-01 v1
  • Checksum
    0FDAB2CB27E93724
MHLPSLSLSLTALAIASPSAAYPHFGSSQPVLHSSSDTTQSRADAIKAAFSHAWDGYLQYAFPHDELHPVSNGYGDSRNGWGASAVDALSTAVIMRNATIVNQILDHVGKIDYSKTNTTVSLFETTIRYLGGMLSGYDLLKGPVSDLVQNSSKIDVLLTQSKNLADVLKFAFDTPSGVPYNNLNITSGGNDGAKTNGLAVTGTLALEWTRLSDLTGDTTYADLSQKAESYLLNPQPKSAEPFPGLVGSNINISNGQFTDAQVSWNGGDDSYYEYLIKMYVYDPKRFGLYKDRWVAAAQSTMQHLASHPSSRPDLTFLASYNNGTLGLSSQHLTCFDGGSFLLGGTVLNRTDFINFGLDLVSGCHDTYNSTLTGIGPESFSWDTSDIPSSQQSLYEKAGFYITSGAYILRPEVIESFYYAWRVTGQETYRDWIWSAFSAVNDYCRTSSGFSGLTDVNAANGGSRYDNQESFLFAEVMKYSYMAFAEDAAWQVQPGSGNQFVFNTEAHPVRVSST

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D49827
EMBL· GenBank· DDBJ
BAA08634.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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