Q12481 · RRP36_YEAST
- ProteinrRNA biogenesis protein RRP36
- GeneRRP36
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids300 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | 90S preribosome | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Cellular Component | small-subunit processome | |
Biological Process | maturation of SSU-rRNA | |
Biological Process | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | ribosomal small subunit biogenesis | |
Biological Process | rRNA processing |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namerRNA biogenesis protein RRP36
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ12481
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000268165 | 1-300 | rRNA biogenesis protein RRP36 | |||
Sequence: MSYYFKNLKPDLNSDVEEDDGNLLESIMANKSKREIDEQESSDDELKTLSFGSLKKAETVIDEEDFKDTKPVHKKPITTTYREESFDEDEDSEDQSDEDAGFFEEDSEDETHHGQKVPKKKSKHAPVEQSSKKRVPRVRNIPGLEIPRNKRSNLYQDIRFDKSTGKALDSSIIRKRYQFLDEYREKEIDELQKLLQERKFLSKIDQGEREEMEQRLKSMKSRLQSMKNKDLEREILKEYENDMNKNNNTRYHLKKSEKRKVVQKWKFDHMKAKQREKVMERKRKKRLGKEFKQFEFHNRR | ||||||
Modified residue | 14 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 41 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 42 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Associates with 90S and pre-40S pre-ribosomal particles. Interacts with CKA1, CKA2, CKB1, CKB2, PWP2, UTP15, UTP17 and UTP22.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q12481 | CKA1 P15790 | 3 | EBI-31770, EBI-9533 | |
BINARY | Q12481 | ENP1 P38333 | 2 | EBI-31770, EBI-6482 | |
BINARY | Q12481 | HAS1 Q03532 | 2 | EBI-31770, EBI-8170 | |
BINARY | Q12481 | HCA4 P20448 | 3 | EBI-31770, EBI-5612 | |
BINARY | Q12481 | KRR1 P25586 | 4 | EBI-31770, EBI-21773 | |
BINARY | Q12481 | NAN1 Q02931 | 2 | EBI-31770, EBI-37773 | |
BINARY | Q12481 | PWP2 P25635 | 2 | EBI-31770, EBI-14332 | |
BINARY | Q12481 | SAS10 Q12136 | 3 | EBI-31770, EBI-36084 | |
BINARY | Q12481 | UTP15 Q04305 | 2 | EBI-31770, EBI-28183 | |
BINARY | Q12481 | UTP22 P53254 | 3 | EBI-31770, EBI-1878 | |
BINARY | Q12481 | UTP25 P40498 | 2 | EBI-31770, EBI-25113 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 33-83 | Basic and acidic residues | ||||
Sequence: KREIDEQESSDDELKTLSFGSLKKAETVIDEEDFKDTKPVHKKPITTTYRE | ||||||
Region | 33-151 | Disordered | ||||
Sequence: KREIDEQESSDDELKTLSFGSLKKAETVIDEEDFKDTKPVHKKPITTTYREESFDEDEDSEDQSDEDAGFFEEDSEDETHHGQKVPKKKSKHAPVEQSSKKRVPRVRNIPGLEIPRNKR | ||||||
Compositional bias | 84-105 | Acidic residues | ||||
Sequence: ESFDEDEDSEDQSDEDAGFFEE | ||||||
Compositional bias | 106-139 | Basic and acidic residues | ||||
Sequence: DSEDETHHGQKVPKKKSKHAPVEQSSKKRVPRVR | ||||||
Coiled coil | 184-248 | |||||
Sequence: REKEIDELQKLLQERKFLSKIDQGEREEMEQRLKSMKSRLQSMKNKDLEREILKEYENDMNKNNN |
Sequence similarities
Belongs to the RRP36 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length300
- Mass (Da)36,125
- Last updated1996-11-01 v1
- ChecksumDA075857261E1490
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 33-83 | Basic and acidic residues | ||||
Sequence: KREIDEQESSDDELKTLSFGSLKKAETVIDEEDFKDTKPVHKKPITTTYRE | ||||||
Compositional bias | 84-105 | Acidic residues | ||||
Sequence: ESFDEDEDSEDQSDEDAGFFEE | ||||||
Compositional bias | 106-139 | Basic and acidic residues | ||||
Sequence: DSEDETHHGQKVPKKKSKHAPVEQSSKKRVPRVR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X89633 EMBL· GenBank· DDBJ | CAA61790.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z75195 EMBL· GenBank· DDBJ | CAA99514.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006948 EMBL· GenBank· DDBJ | DAA11051.1 EMBL· GenBank· DDBJ | Genomic DNA |