Q12284 · ERV2_YEAST

Function

function

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1.

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Features

Showing features for binding site.

119620406080100120140160180
TypeIDPosition(s)Description
Binding site78FAD (UniProtKB | ChEBI)
Binding site83FAD (UniProtKB | ChEBI)
Binding site86FAD (UniProtKB | ChEBI)
Binding site127FAD (UniProtKB | ChEBI)
Binding site150FAD (UniProtKB | ChEBI)
Binding site153FAD (UniProtKB | ChEBI)
Binding site157FAD (UniProtKB | ChEBI)
Binding site162FAD (UniProtKB | ChEBI)
Binding site174FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentfungal-type vacuole
Cellular Componentfungal-type vacuole membrane
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionflavin-dependent sulfhydryl oxidase activity
Molecular Functionthiol oxidase activity
Biological Processregulation of protein folding in endoplasmic reticulum

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    FAD-linked sulfhydryl oxidase ERV2
  • EC number

Gene names

    • Name
      ERV2
    • ORF names
      YP3085.03C
    • Ordered locus names
      YPR037C

Organism names

Accessions

  • Primary accession
    Q12284
  • Secondary accessions
    • D6W448

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-12Cytoplasmic
Transmembrane13-35Helical; Signal-anchor
Topological domain36-196Lumenal

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis121Loss of function.
Mutagenesis124Loss of function.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000011881-196FAD-linked sulfhydryl oxidase ERV2
Disulfide bond121↔124Redox-active
Disulfide bond150↔167
Disulfide bond176↔178

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Homodimer. Interacts with the substrate protein PDI1, forming transient intermolecular disulfide bridges.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain72-174ERV/ALR sulfhydryl oxidase

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    196
  • Mass (Da)
    22,141
  • Last updated
    1997-11-01 v1
  • Checksum
    7FEE76B5F01D3D65
MKQIVKRSHAIRIVAALGIIGLWMFFSSNELSIATPGLIKAKSGIDEVQGAAAEKNDARLKEIEKQTIMPLMGDDKVKKEVGRASWKYFHTLLARFPDEPTPEEREKLHTFIGLYAELYPCGECSYHFVKLIEKYPVQTSSRTAAAMWGCHIHNKVNEYLKKDIYDCATILEDYDCGCSDSDGKRVSLEKEAKQHG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z71255
EMBL· GenBank· DDBJ
CAA94987.1
EMBL· GenBank· DDBJ
Genomic DNA
Z68111
EMBL· GenBank· DDBJ
CAA92143.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006949
EMBL· GenBank· DDBJ
DAA11464.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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