Q12280 · IQG1_YEAST

Function

function

Required for the assembly and the contraction of the actomyosin ring at the bud neck during cytokinesis. Seems to be involved in additional tasks during cell division like axial bud-site selection and targeted secretion by recruiting the spatial landmark BUD4, the septin CDC12 and the secretion landmark SEC3 to the bud neck. May be regulated by calcium ions.

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell cortex
Cellular Componentcellular bud neck
Cellular Componentcellular bud neck contractile ring
Cellular Componentcytoplasm
Cellular ComponentMIH complex
Cellular Componentmitotic actomyosin contractile ring
Cellular Componentplasma membrane
Molecular Functionactin filament binding
Molecular Functioncalmodulin binding
Molecular FunctionGTPase activator activity
Molecular Functionmyosin II heavy chain binding
Molecular Functionmyosin II light chain binding
Molecular Functionmyosin light chain binding
Biological Processmitotic actomyosin contractile ring assembly
Biological Processmitotic actomyosin contractile ring assembly actin filament organization
Biological Processmitotic cytokinesis
Biological Processprotein localization to cell division site
Biological Processregulation of actomyosin contractile ring contraction
Biological Processregulation of cell wall organization or biogenesis
Biological Processregulation of cytokinesis
Biological Processregulation of mitotic actomyosin contractile ring contraction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ras GTPase-activating-like protein IQG1
  • Alternative names
    • Cytokinesis protein 1
    • IQGAP-related protein 1

Gene names

    • Name
      IQG1
    • Synonyms
      CYK1
    • Ordered locus names
      YPL242C

Organism names

Accessions

  • Primary accession
    Q12280
  • Secondary accessions
    • D6W3C9

Proteomes

Organism-specific databases

Subcellular Location

Bud neck
Note: Forms a ring at the bud neck in a MLC1-dependent manner, which contracts at the end of cytokinesis.

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis457In IQG1-1; causes a defect in cytokinesis at 37 degrees Celsius.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000566521-1495Ras GTPase-activating-like protein IQG1
Modified residue264Phosphothreonine
Modified residue268Phosphoserine
Modified residue299Phosphothreonine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with AFR1 (PubMed:9679143).
Interacts with AKR1 (PubMed:9679143).
Interacts with activated CDC42 (PubMed:9679143).
Interacts with calmodulin CMD1 (PubMed:9950677).
Interacts with myosin MYO1 and its light chain MLC1 (PubMed:11082046).
Interacts with BUD4 (PubMed:12446742).
Interacts with INN1 (PubMed:18344988).
Interacts with SEC3 (PubMed:12446742).
Interacts with TEM1 (PubMed:9950677).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q12280BUD4 P471364EBI-35351, EBI-3848
BINARY Q12280MLC1 P5314113EBI-35351, EBI-10988

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, coiled coil.

TypeIDPosition(s)Description
Domain108-221Calponin-homology (CH)
Domain447-467IQ 1
Domain538-567IQ 2
Domain568-597IQ 3
Domain599-628IQ 4
Domain629-658IQ 5
Domain687-716IQ 6
Domain717-746IQ 7
Coiled coil759-798
Domain860-1071Ras-GAP

Domain

The calponin homology (CH) domain binds to actin filaments and is required for their recruitment to the bud neck.
The IQ domains provide the interaction surface for the myosin light chain MLC1.
The Ras-GAP domain is required for contraction of the actomyosin ring and is needed for the interaction with TEM1. It probably does not stimulate GTPase activity.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,495
  • Mass (Da)
    172,830
  • Last updated
    1996-11-01 v1
  • Checksum
    C0C7582808154DCC
MTAYSGSPSKPGNNNSYLNRYVENLGTNVTPPLRPQSSSKINSSLNIASPSHLKTKTSASNSSATILSKKVESSVSKLKPSLPNKLVGKYTVDLSNYSKIELRYYEFLCRVSEVKIWIEAVIEEALPSEIELCVGDSLRNGVFLAKLTQRINPDLTTVIFPAGDKLQFKHTQNINAFFGLVEHVGVPDSFRFELQDLYNKKNIPQVFETLHILISMINKKWPGKTPALTNVSGQISFTKEEIAACKKAWPRIRDFKSLGTNINTAPASPEEPKEKRSGLIKDFNKFERPNIPVEEILITPRKNITDANCSDFSNTPSPYNEAPKMSNLDVVVEKRKFTPIEPSLLGPTPSLEYSPIKNKSLSYYSPTISKYLTYDTEFYTRRSRAREEDLNYYQTFKYSPSHYSPMRRERMTEEQFLEKVVQLQNICRGVNTRFNLYIQKRLLNLFEQDILRFQACLRGNKFRVLSSMYLPIRRAKIDVPHVEAIQSRIKGSRIRYKYDKLKFTLSRFSCTVELLQAYCRSKLLKTTVNTKLNDIEISHYPLTKLQSYMRASYVRKKVMSLNTKLNDERESIMKFSAIIRGNVVRCSEDAILSAVHDVHKENISKLQSLIRGIFTRSCLASIIYSLGKENCNIIQLSACIRGNAVRHKVQSLFAPENNLSETVHDLQGLVRGILVRYTLDLVDDIVEYNNLALFQAFSRGALVRESLDQKSSFYKRNVRSVIMIQSWIRKSLQRSAYLELLDCPNPSLWAVKKFVHLLNGTATIEEVQNQLESCQASLDSENMKKERLLKSIRQQLNINGVLDKFGLLKDKDHELGISDSTIPKSKYQKYEKLFYMLQVDPSYWKLLYLKEPEFVAKNVYMTFGTVNQRMNDRERSYFTRFVCEMLQNAINEAPSIESFLDNRSQFWQTILQDFLRRESPEFFSIIVPVLDYLSDPVVDFESDPYKIYQEIHGFSSPQHCSPVDDASTKNKFIDNLRCLWHAIEMVAEIYTRKVHTIPVEIRYLCTKIFCYAADKNIEEIDSLRAISSILVNVFVSEYLVNREYYGYKDSNVQKNNQKIDILMKSLATVFEIKNFDGFLDPLNQYANEIKPHIKDVLYNVLVDPEYEQEGDRLIYLDMVSPSPKLELLTEKVLEISGKFEEYLNEFPEADILHDILEKNLDNSSFPRSGRVTLELDASAYRFLVSDDKMRKIYDQVKRAFVYMMQIEDVDTNLYDLSISTILPQDEPNFANFLEQNPKIRDDPMIQKLKPLKYFTLKNVTLKKIHELESTGTFCSSDNKLQNFLNDIANTIKNPNYAIDYVTQEIYITKETLTKISEMNHSLDIELSRLKKHVDHTIKDFQKAKDFSPVHKSKFGNFKNAVKKVQGRERSELQGMKFKWNTKQLYERGVLKTIRGEKLAELTVKVFGSSGPKFPDIIFKISTSDGSRFGIQMIDKRKGPDKRYSDDVDSFSFKDLIKTQVEPKIETWKLFHSNVVVNNSQLLHLIVSFFYKRNAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF019644
EMBL· GenBank· DDBJ
AAB70827.1
EMBL· GenBank· DDBJ
Genomic DNA
Z73598
EMBL· GenBank· DDBJ
CAA97963.1
EMBL· GenBank· DDBJ
Genomic DNA
Z67751
EMBL· GenBank· DDBJ
CAA91603.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006949
EMBL· GenBank· DDBJ
DAA11195.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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