Q12270 · RBD2_YEAST
- ProteinRhomboid-type serine protease 2
- GeneRBD2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids262 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.
Miscellaneous
Present with 7850 molecules/cell in log phase SD medium.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 124 | Nucleophile | ||||
Sequence: S | ||||||
Active site | 179 | |||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Cellular Component | nuclear periphery | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRhomboid-type serine protease 2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ12270
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Multi-pass membrane protein
Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-16 | Cytoplasmic | ||||
Sequence: MNWKSYVFPGGHPPAA | ||||||
Transmembrane | 17-37 | Helical | ||||
Sequence: LTTGLVVFLTAIYLLSFIFAL | ||||||
Topological domain | 38-57 | Lumenal | ||||
Sequence: REDLSLAPESLFKLQMSRLS | ||||||
Transmembrane | 58-78 | Helical | ||||
Sequence: LYPLIHLSLPHLLFNVLAIWA | ||||||
Topological domain | 79-89 | Cytoplasmic | ||||
Sequence: PLNLFEETHGT | ||||||
Transmembrane | 90-110 | Helical | ||||
Sequence: VYTGVFLNLSALFAGILYCLL | ||||||
Topological domain | 111-112 | Lumenal | ||||
Sequence: GK | ||||||
Transmembrane | 113-133 | Helical | ||||
Sequence: LLYPEALVAGASGWCFTLFAY | ||||||
Topological domain | 134-151 | Cytoplasmic | ||||
Sequence: YSFKESQIRPRTRIFRTD | ||||||
Transmembrane | 152-168 | Helical | ||||
Sequence: YSIPTLYTPLVLLVAIA | ||||||
Topological domain | 169-174 | Lumenal | ||||
Sequence: VVIPGS | ||||||
Transmembrane | 175-191 | Helical | ||||
Sequence: SFWGHFFGLCVGYAIGY | ||||||
Topological domain | 192-262 | Cytoplasmic | ||||
Sequence: KESWFNKITPPGWIITKIEKSLDGLIRLIPWGIKYYRDEDIDRTKDYEPLMSTETPLPLHNDNSGTVLGTA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000206193 | 1-262 | Rhomboid-type serine protease 2 | |||
Sequence: MNWKSYVFPGGHPPAALTTGLVVFLTAIYLLSFIFALREDLSLAPESLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETHGTVYTGVFLNLSALFAGILYCLLGKLLYPEALVAGASGWCFTLFAYYSFKESQIRPRTRIFRTDYSIPTLYTPLVLLVAIAVVIPGSSFWGHFFGLCVGYAIGYKESWFNKITPPGWIITKIEKSLDGLIRLIPWGIKYYRDEDIDRTKDYEPLMSTETPLPLHNDNSGTVLGTA |
Proteomic databases
Interaction
Subunit
Interacts with SNX3.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q12270 | AKR1 P39010 | 3 | EBI-31471, EBI-2421 | |
BINARY | Q12270 | VAM7 P32912 | 3 | EBI-31471, EBI-20232 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 243-262 | Disordered | ||||
Sequence: STETPLPLHNDNSGTVLGTA | ||||||
Compositional bias | 247-262 | Polar residues | ||||
Sequence: PLPLHNDNSGTVLGTA |
Sequence similarities
Belongs to the peptidase S54 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length262
- Mass (Da)29,500
- Last updated1996-11-01 v1
- Checksum3A436E3FEAB7FD35
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 247-262 | Polar residues | ||||
Sequence: PLPLHNDNSGTVLGTA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z73602 EMBL· GenBank· DDBJ | CAA97967.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z67751 EMBL· GenBank· DDBJ | CAA91598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006949 EMBL· GenBank· DDBJ | DAA11191.1 EMBL· GenBank· DDBJ | Genomic DNA |