Q12270 · RBD2_YEAST

Function

function

Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.

Miscellaneous

Present with 7850 molecules/cell in log phase SD medium.

Catalytic activity

  • Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.
    EC:3.4.21.105 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

126220406080100120140160180200220240260
TypeIDPosition(s)Description
Active site124Nucleophile
Active site179

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Cellular Componentnuclear periphery
Molecular Functionserine-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Rhomboid-type serine protease 2
  • EC number
  • Alternative names
    • Rhomboid protein 2

Gene names

    • Name
      RBD2
    • Ordered locus names
      YPL246C

Organism names

Accessions

  • Primary accession
    Q12270
  • Secondary accessions
    • D6W3C5

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus membrane
; Multi-pass membrane protein
Golgi apparatus, cis-Golgi network membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-16Cytoplasmic
Transmembrane17-37Helical
Topological domain38-57Lumenal
Transmembrane58-78Helical
Topological domain79-89Cytoplasmic
Transmembrane90-110Helical
Topological domain111-112Lumenal
Transmembrane113-133Helical
Topological domain134-151Cytoplasmic
Transmembrane152-168Helical
Topological domain169-174Lumenal
Transmembrane175-191Helical
Topological domain192-262Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002061931-262Rhomboid-type serine protease 2

Proteomic databases

Interaction

Subunit

Interacts with SNX3.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q12270AKR1 P390103EBI-31471, EBI-2421
BINARY Q12270VAM7 P329123EBI-31471, EBI-20232

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region243-262Disordered
Compositional bias247-262Polar residues

Sequence similarities

Belongs to the peptidase S54 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    262
  • Mass (Da)
    29,500
  • Last updated
    1996-11-01 v1
  • Checksum
    3A436E3FEAB7FD35
MNWKSYVFPGGHPPAALTTGLVVFLTAIYLLSFIFALREDLSLAPESLFKLQMSRLSLYPLIHLSLPHLLFNVLAIWAPLNLFEETHGTVYTGVFLNLSALFAGILYCLLGKLLYPEALVAGASGWCFTLFAYYSFKESQIRPRTRIFRTDYSIPTLYTPLVLLVAIAVVIPGSSFWGHFFGLCVGYAIGYKESWFNKITPPGWIITKIEKSLDGLIRLIPWGIKYYRDEDIDRTKDYEPLMSTETPLPLHNDNSGTVLGTA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias247-262Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z73602
EMBL· GenBank· DDBJ
CAA97967.1
EMBL· GenBank· DDBJ
Genomic DNA
Z67751
EMBL· GenBank· DDBJ
CAA91598.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006949
EMBL· GenBank· DDBJ
DAA11191.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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