Q12200 · NPC1_YEAST

Function

function

Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments.

Miscellaneous

Present with 521 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentfungal-type vacuole membrane
Cellular Componentmembrane
Molecular Functionsterol binding
Biological Processsphingolipid metabolic process
Biological Processsterol transport

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 2.A.6.6.3the resistance-nodulation-cell division (rnd) superfamily

Names & Taxonomy

Protein names

  • Recommended name
    NPC intracellular sterol transporter 1-related protein 1
  • Alternative names
    • Niemann-Pick type C-related protein 1

Gene names

    • Name
      NCR1
    • Ordered locus names
      YPL006W

Organism names

Accessions

  • Primary accession
    Q12200
  • Secondary accessions
    • D6W406

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane260-280Helical
Transmembrane341-361Helical
Transmembrane556-576Helical
Transmembrane585-605Helical
Transmembrane616-636Helical
Transmembrane667-687Helical
Transmembrane698-718Helical
Transmembrane752-772Helical
Transmembrane1000-1020Helical
Transmembrane1027-1047Helical
Transmembrane1054-1074Helical
Transmembrane1099-1119Helical
Transmembrane1133-1153Helical

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis718Sphingolipids mislocalization and no growth at 38 degrees Celsius.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000026868520-1170
Disulfide bond23↔75
Disulfide bond29↔41
Disulfide bond64↔110
Disulfide bond76↔114
Disulfide bond98↔230
Disulfide bond101↔156
Glycosylation123N-linked (GlcNAc...) asparagine
Glycosylation145N-linked (GlcNAc...) asparagine
Glycosylation178N-linked (GlcNAc...) asparagine
Disulfide bond223↔235
Disulfide bond232↔239
Glycosylation314N-linked (GlcNAc...) asparagine
Glycosylation401N-linked (GlcNAc...) asparagine
Disulfide bond438↔447
Disulfide bond473↔480
Glycosylation513N-linked (GlcNAc...) asparagine
Disulfide bond822↔828
Disulfide bond868↔925
Disulfide bond869↔891
Disulfide bond879↔888
Glycosylation900N-linked (GlcNAc...) asparagine
Glycosylation940N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q12200PDR5 P333022EBI-32032, EBI-13038

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain557-717SSD

Sequence similarities

Belongs to the patched family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,170
  • Mass (Da)
    132,645
  • Last updated
    1996-11-01 v1
  • Checksum
    F976EBDB36C36C92
MNVLWIIALVGQLMRLVQGTATCAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETSKLLVEVCGEEWKEVRYACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKCACSDCQESCPHLKPLKDGVCKVGPLPCFSLSVLIFYTICALFAFMWYYLCKRKKNGAMIVDDDIVPESGSLDESETNVFESFNNETNFFNGKLANLFTKVGQFSVENPYKILITTVFSIFVFSFIIFQYATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIFVVNETGPVLSYETLHWWFDVENFITEELQSSENIGYQDLCFRPTEDSTCVIESFTQYFQGALPNKDSWKRELQECGKFPVNCLPTFQQPLKTNLLFSDDDILNAHAFVVTLLLTNHTQSANRWEERLEEYLLDLKVPEGLRISFNTEISLEKELNNNNDISTVAISYLMMFLYATWALRRKDGKTRLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKPEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQITGNEETKESFLKTFYFKMLTQKRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVKNLDLTKRQNQQKICGKFTTCERDSLANVLEQERHRSTITEPLANWLDDYFMFLNPQNDQCCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEYLSIWINAPSDPCPLGGRAPYSTALVYNETSVSASVFRTAHHPLRSQKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVPSETKKDANSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLIIVAALHALLFLPALLSLFGGESYRDDSIEAED

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U33335
EMBL· GenBank· DDBJ
AAB68099.1
EMBL· GenBank· DDBJ
Genomic DNA
Z48483
EMBL· GenBank· DDBJ
CAA88380.1
EMBL· GenBank· DDBJ
Genomic DNA
Z71255
EMBL· GenBank· DDBJ
CAA95035.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006949
EMBL· GenBank· DDBJ
DAA11422.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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