Q12200 · NPC1_YEAST
- ProteinNPC intracellular sterol transporter 1-related protein 1
- GeneNCR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1170 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Involved in sphingolipid trafficking. May recycle sphingolipids between cellular membranous compartments.
Miscellaneous
Present with 521 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | fungal-type vacuole membrane | |
Cellular Component | membrane | |
Molecular Function | sterol binding | |
Biological Process | sphingolipid metabolic process | |
Biological Process | sterol transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameNPC intracellular sterol transporter 1-related protein 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ12200
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Vacuole membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 260-280 | Helical | ||||
Sequence: LSVLIFYTICALFAFMWYYLC | ||||||
Transmembrane | 341-361 | Helical | ||||
Sequence: ILITTVFSIFVFSFIIFQYAT | ||||||
Transmembrane | 556-576 | Helical | ||||
Sequence: NDISTVAISYLMMFLYATWAL | ||||||
Transmembrane | 585-605 | Helical | ||||
Sequence: LLLGISGLLIVLASIVCAAGF | ||||||
Transmembrane | 616-636 | Helical | ||||
Sequence: IIAEVIPFLILAIGIDNIFLI | ||||||
Transmembrane | 667-687 | Helical | ||||
Sequence: ILMSLLCQTGCFLIAAFVTMP | ||||||
Transmembrane | 698-718 | Helical | ||||
Sequence: VSVIFNGVLQLTAYVSILSLY | ||||||
Transmembrane | 752-772 | Helical | ||||
Sequence: IIIIFSAWFFTSLVFLPEIQF | ||||||
Transmembrane | 1000-1020 | Helical | ||||
Sequence: LTLKLIGSAIILIFFISSVFL | ||||||
Transmembrane | 1027-1047 | Helical | ||||
Sequence: FLLALVVTMIIVDIGALMALL | ||||||
Transmembrane | 1054-1074 | Helical | ||||
Sequence: VSLVNLIICVGLGVEFCVHIV | ||||||
Transmembrane | 1099-1119 | Helical | ||||
Sequence: IGESVIKGITLTKFIGVCVLA | ||||||
Transmembrane | 1133-1153 | Helical | ||||
Sequence: MWFTLIIVAALHALLFLPALL |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 718 | Sphingolipids mislocalization and no growth at 38 degrees Celsius. | ||||
Sequence: Y → D |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MNVLWIIALVGQLMRLVQG | ||||||
Chain | PRO_0000268685 | 20-1170 | NPC intracellular sterol transporter 1-related protein 1 | |||
Sequence: TATCAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETSKLLVEVCGEEWKEVRYACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKCACSDCQESCPHLKPLKDGVCKVGPLPCFSLSVLIFYTICALFAFMWYYLCKRKKNGAMIVDDDIVPESGSLDESETNVFESFNNETNFFNGKLANLFTKVGQFSVENPYKILITTVFSIFVFSFIIFQYATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIFVVNETGPVLSYETLHWWFDVENFITEELQSSENIGYQDLCFRPTEDSTCVIESFTQYFQGALPNKDSWKRELQECGKFPVNCLPTFQQPLKTNLLFSDDDILNAHAFVVTLLLTNHTQSANRWEERLEEYLLDLKVPEGLRISFNTEISLEKELNNNNDISTVAISYLMMFLYATWALRRKDGKTRLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKPEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYEKRSNYKQITGNEETKESFLKTFYFKMLTQKRLIIIIFSAWFFTSLVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVKNLDLTKRQNQQKICGKFTTCERDSLANVLEQERHRSTITEPLANWLDDYFMFLNPQNDQCCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEYLSIWINAPSDPCPLGGRAPYSTALVYNETSVSASVFRTAHHPLRSQKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRSFTVVPSETKKDANSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIFDVFYFRMWFTLIIVAALHALLFLPALLSLFGGESYRDDSIEAED | ||||||
Disulfide bond | 23↔75 | |||||
Sequence: CAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETSKLLVEVCGEEWKEVRYAC | ||||||
Disulfide bond | 29↔41 | |||||
Sequence: CGKKSVFGNELPC | ||||||
Disulfide bond | 64↔110 | |||||
Sequence: CGEEWKEVRYACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFC | ||||||
Disulfide bond | 76↔114 | |||||
Sequence: CTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTC | ||||||
Disulfide bond | 98↔230 | |||||
Sequence: CPACLKNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKC | ||||||
Disulfide bond | 101↔156 | |||||
Sequence: CLKNFNNLFCHFTCAADQGRFVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSC | ||||||
Glycosylation | 123 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 145 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 178 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 223↔235 | |||||
Sequence: CDDAQYKCACSDC | ||||||
Disulfide bond | 232↔239 | |||||
Sequence: CSDCQESC | ||||||
Glycosylation | 314 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 401 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 438↔447 | |||||
Sequence: CFRPTEDSTC | ||||||
Disulfide bond | 473↔480 | |||||
Sequence: CGKFPVNC | ||||||
Glycosylation | 513 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 822↔828 | |||||
Sequence: CGKFTTC | ||||||
Disulfide bond | 868↔925 | |||||
Sequence: CCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEYLSIWINAPSDPC | ||||||
Disulfide bond | 869↔891 | |||||
Sequence: CRLKKGTDEVCPPSFPSRRCETC | ||||||
Disulfide bond | 879↔888 | |||||
Sequence: CPPSFPSRRC | ||||||
Glycosylation | 900 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 940 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q12200 | PDR5 P33302 | 2 | EBI-32032, EBI-13038 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 557-717 | SSD | ||||
Sequence: DISTVAISYLMMFLYATWALRRKDGKTRLLLGISGLLIVLASIVCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKPEYSIDQKIISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSL |
Sequence similarities
Belongs to the patched family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length1,170
- Mass (Da)132,645
- Last updated1996-11-01 v1
- ChecksumF976EBDB36C36C92
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U33335 EMBL· GenBank· DDBJ | AAB68099.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z48483 EMBL· GenBank· DDBJ | CAA88380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z71255 EMBL· GenBank· DDBJ | CAA95035.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006949 EMBL· GenBank· DDBJ | DAA11422.1 EMBL· GenBank· DDBJ | Genomic DNA |