Q12184 · ADRX_YEAST
- ProteinAdrenodoxin homolog, mitochondrial
- GeneYAH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids172 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Iron-sulfur protein that transfers electrons in a wide variety of metabolic reactions. Involved in heme A biosynthesis and in iron-sulfur cluster assembly (PubMed:10655482).
Transfers electrons from adrenodoxin reductase ARH1 to heme A synthase COX15, a heme protein that catalyzes the conversion of heme O to heme A (PubMed:11248251, PubMed:11788607).
Required for the de novo synthesis of Fe-S clusters on iron sulfur cluster assembly protein ISU1. Interact in its reduced state with ISU1 to productively deliver electrons for Fe-S cluster synthesis (PubMed:12970193, PubMed:15211518, PubMed:25358379).
Essential for coenzyme Q biosynthesis. May transfer the electrons required for the hydroxylation reaction performed by COQ6 (PubMed:20534343, PubMed:21944752).
Transfers electrons from adrenodoxin reductase ARH1 to heme A synthase COX15, a heme protein that catalyzes the conversion of heme O to heme A (PubMed:11248251, PubMed:11788607).
Required for the de novo synthesis of Fe-S clusters on iron sulfur cluster assembly protein ISU1. Interact in its reduced state with ISU1 to productively deliver electrons for Fe-S cluster synthesis (PubMed:12970193, PubMed:15211518, PubMed:25358379).
Essential for coenzyme Q biosynthesis. May transfer the electrons required for the hydroxylation reaction performed by COQ6 (PubMed:20534343, PubMed:21944752).
Miscellaneous
Present with 14800 molecules/cell in log phase SD medium.
Cofactor
Note: Binds 1 [2Fe-2S] cluster.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | iron-sulfur cluster assembly complex | |
Cellular Component | mitochondrial matrix | |
Cellular Component | mitochondrion | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | electron transfer activity | |
Molecular Function | iron-sulfur cluster binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | |
Biological Process | electron transport chain | |
Biological Process | heme A biosynthetic process | |
Biological Process | iron-sulfur cluster assembly | |
Biological Process | P450-containing electron transport chain | |
Biological Process | ubiquinone biosynthetic process |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdrenodoxin homolog, mitochondrial
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ12184
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-16 | Mitochondrion | ||||
Sequence: MLKIVTRAGHTARISN | ||||||
Chain | PRO_0000000994 | 17-172 | Adrenodoxin homolog, mitochondrial | |||
Sequence: IAAHLLRTSPSLLTRTTTTTRFLPFSTSSFLNHGHLKKPKPGEELKITFILKDGSQKTYEVCEGETILDIAQGHNLDMEGACGGSCACSTCHVIVDPDYYDALPEPEDDENDMLDLAYGLTETSRLGCQIKMSKDIDGIRVALPQMTRNVNNNDFS |
Proteomic databases
Interaction
Subunit
Interacts in its reduced state with the apo form of ISU1.
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 61-163 | 2Fe-2S ferredoxin-type | ||||
Sequence: LKITFILKDGSQKTYEVCEGETILDIAQGHNLDMEGACGGSCACSTCHVIVDPDYYDALPEPEDDENDMLDLAYGLTETSRLGCQIKMSKDIDGIRVALPQMT |
Sequence similarities
Belongs to the adrenodoxin/putidaredoxin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length172
- Mass (Da)18,932
- Last updated1996-11-01 v1
- ChecksumD7DB9CFACBED1BFC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z73608 EMBL· GenBank· DDBJ | CAA97975.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z67751 EMBL· GenBank· DDBJ | CAA91592.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006949 EMBL· GenBank· DDBJ | DAA11185.1 EMBL· GenBank· DDBJ | Genomic DNA |