Q12013 · AKR2_YEAST
- ProteinProbable palmitoyltransferase AKR2
- GeneAKR2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids749 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May be involved in constitutive endocytosis of a-factor receptor STE3.
Miscellaneous
Present with 815 molecules/cell in log phase SD medium.
Catalytic activity
- hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 476 | S-palmitoyl cysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | fungal-type vacuole | |
Cellular Component | fungal-type vacuole membrane | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Molecular Function | palmitoyltransferase activity | |
Molecular Function | protein-cysteine S-palmitoyltransferase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable palmitoyltransferase AKR2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ12013
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-306 | Cytoplasmic | ||||
Sequence: MTSMSIIDDENVKKTSNGAAVVTDVAQHAVSDSDNNKAQLLGDGSNTEYVVDIFIEAAKDGDLKVVKDVVESGAVDINNDRIDELSGLHWACINNRFSVAKFLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNRGFNALHCALVGGDQRVICDLILSGANFYERNNQKQDCFDLAEGMGTKSLFEQALQHHGYDRLGNQKDKLFKKSSHAQFTIFLSP | ||||||
Transmembrane | 307-327 | Helical | ||||
Sequence: FLLMVYIYLISLVLSPVLAIM | ||||||
Transmembrane | 328-348 | Helical | ||||
Sequence: LSLLVTVVMVNTLKKFVLPCL | ||||||
Topological domain | 349-360 | Cytoplasmic | ||||
Sequence: PRKNTYKVSLTR | ||||||
Transmembrane | 361-381 | Helical | ||||
Sequence: TPFFSGLFLSTFCFLIYIWTK | ||||||
Topological domain | 382-392 | Extracellular | ||||
Sequence: KLYPYSVSDYT | ||||||
Transmembrane | 393-413 | Helical | ||||
Sequence: MKNVQFLVTSFLTVVLFLRLV | ||||||
Topological domain | 414-489 | Cytoplasmic | ||||
Sequence: RSDPGCLKTDDSLTSIQETIKQLIDLGKFDRENFCVETLERKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHK | ||||||
Transmembrane | 490-510 | Helical | ||||
Sequence: LFVFFAVTVQYHMFLFMWLCL | ||||||
Topological domain | 511-546 | Extracellular | ||||
Sequence: AYFKKTNYIYEQVEEYARCALLKNETLCKGSNYDPS | ||||||
Transmembrane | 547-567 | Helical | ||||
Sequence: TFFLFIWISVNFIWLGAMLIV | ||||||
Topological domain | 568-749 | Cytoplasmic | ||||
Sequence: QFFQILKGITTPELFILIKEEHKAKFINLIPFENSIYTSESKGVEDSDMIPEGPSATTITHTISIDGLEPRNRRRAILSACFSMMGINQWLVTIKEIVGITHILHGQVPQQHHSSLLRSFLVTNHWKTNLTDFWLNSDVTAPLWQRFFYSSDTSKAMLGGTEVDYYELYEYPAREGEVLRPN |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000212936 | 1-749 | Probable palmitoyltransferase AKR2 | |||
Sequence: MTSMSIIDDENVKKTSNGAAVVTDVAQHAVSDSDNNKAQLLGDGSNTEYVVDIFIEAAKDGDLKVVKDVVESGAVDINNDRIDELSGLHWACINNRFSVAKFLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNRGFNALHCALVGGDQRVICDLILSGANFYERNNQKQDCFDLAEGMGTKSLFEQALQHHGYDRLGNQKDKLFKKSSHAQFTIFLSPFLLMVYIYLISLVLSPVLAIMLSLLVTVVMVNTLKKFVLPCLPRKNTYKVSLTRTPFFSGLFLSTFCFLIYIWTKKLYPYSVSDYTMKNVQFLVTSFLTVVLFLRLVRSDPGCLKTDDSLTSIQETIKQLIDLGKFDRENFCVETLERKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHKLFVFFAVTVQYHMFLFMWLCLAYFKKTNYIYEQVEEYARCALLKNETLCKGSNYDPSTFFLFIWISVNFIWLGAMLIVQFFQILKGITTPELFILIKEEHKAKFINLIPFENSIYTSESKGVEDSDMIPEGPSATTITHTISIDGLEPRNRRRAILSACFSMMGINQWLVTIKEIVGITHILHGQVPQQHHSSLLRSFLVTNHWKTNLTDFWLNSDVTAPLWQRFFYSSDTSKAMLGGTEVDYYELYEYPAREGEVLRPN | ||||||
Glycosylation | 534 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for repeat, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 49-79 | ANK 1 | ||||
Sequence: YVVDIFIEAAKDGDLKVVKDVVESGAVDINN | ||||||
Repeat | 83-112 | ANK 2 | ||||
Sequence: DELSGLHWACINNRFSVAKFLLLRGANPNQ | ||||||
Repeat | 117-146 | ANK 3 | ||||
Sequence: GGATALHWAARYGNIYIVDLLLKHGADPTL | ||||||
Repeat | 150-183 | ANK 4 | ||||
Sequence: QGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDI | ||||||
Repeat | 189-218 | ANK 5 | ||||
Sequence: NNRTPLLWAAYQGDFLTVELLLKFGSTVAW | ||||||
Repeat | 222-251 | ANK 6 | ||||
Sequence: RGFNALHCALVGGDQRVICDLILSGANFYE | ||||||
Domain | 446-496 | DHHC | ||||
Sequence: NFCVETLERKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHKLFVFFAV |
Domain
The DHHC domain is required for palmitoyltransferase activity.
Sequence similarities
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length749
- Mass (Da)85,236
- Last updated1996-11-01 v1
- Checksum887F5A02B9EE030A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X87331 EMBL· GenBank· DDBJ | CAA60751.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z74942 EMBL· GenBank· DDBJ | CAA99224.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006948 EMBL· GenBank· DDBJ | DAA10816.1 EMBL· GenBank· DDBJ | Genomic DNA |