Q10T43 · PSD1_ORYSJ

Function

function

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.

Catalytic activity

Cofactor

pyruvate (UniProtKB | Rhea| CHEBI:15361 )

Note: Binds 1 pyruvoyl group covalently per subunit.

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.

Features

Showing features for active site, site.

TypeIDPosition(s)Description
Active site173Charge relay system; for autoendoproteolytic cleavage activity
Active site273Charge relay system; for autoendoproteolytic cleavage activity
Site386-387Cleavage (non-hydrolytic); by autocatalysis
Active site387Charge relay system; for autoendoproteolytic cleavage activity
Active site387Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Molecular Functionphosphatidylserine decarboxylase activity
Biological Processphosphatidylethanolamine biosynthetic process
Biological Processprotein autoprocessing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      PSD1
    • Ordered locus names
      Os03g0101900, LOC_Os03g01216

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    Q10T43
  • Secondary accessions
    • A0A0P0VRT9

Proteomes

Genome annotation databases

Subcellular Location

Phosphatidylserine decarboxylase 1 beta chain

Mitochondrion inner membrane
; Single-pass membrane protein

Phosphatidylserine decarboxylase 1 alpha chain

Mitochondrion inner membrane
; Peripheral membrane protein
Note: Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain22-48Mitochondrial matrix
Transmembrane49-67Helical
Topological domain68-438Mitochondrial intermembrane

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-21Mitochondrion
ChainPRO_000042952122-386Phosphatidylserine decarboxylase 1 beta chain
ChainPRO_000042952022-438Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
Modified residue387Pyruvic acid (Ser); by autocatalysis
ChainPRO_0000429522387-438Phosphatidylserine decarboxylase 1 alpha chain

Post-translational modification

Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

Keywords

Proteomic databases

Interaction

Subunit

Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    438
  • Mass (Da)
    49,288
  • Last updated
    2006-08-22 v1
  • Checksum
    B706B76F9965EABC
MRRFRVWPPSPSPWPLLASRPCPHSHHHRSPFHASANSGARQGNFILPGATAATLVMFGILHARRMYEDQKVVERKEKGIEPEFSPDFKASFLRLLPLRSMSRLWGSLMEVELPVFMRPAIYKAWARAFHSNLQEAAMPLEEYPSLQAFFIRSLKEGSRPIDADPNCLVSPVDGKVLRLGELRGPGTMIEQVKGFSYSAASLLGASSSLHGAEEEDFSREHTEQSNPADSNAKSWWRVSVAKPKLWDQTLLSPKKGIFYCVIYLHPGDYHRVHSPVDWNIIKRRHFSGHLFPQNERAVRTIRNLYVENERVVLEGQWKEGFVAIAAIGATNVGSIKLYIEPELRTNRAGSKILNSQPEPPDDRVYEPVGTGVMVKKGEEIAGFKMGSTVVMVFEAPVVSKARWREDGSGTVTSDFDFCIKAGDRIRVGEAIGRWTSRE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DP000009
EMBL· GenBank· DDBJ
ABF93486.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008209
EMBL· GenBank· DDBJ
BAF10572.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014959
EMBL· GenBank· DDBJ
BAS81828.1
EMBL· GenBank· DDBJ
Genomic DNA
AK072180
EMBL· GenBank· DDBJ
BAG92859.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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