Q10MU6 · Q10MU6_ORYSJ
- ProteinE1 ubiquitin-activating enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1064 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 640 | Glycyl thioester intermediate | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | ubiquitin activating enzyme activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE1 ubiquitin-activating enzyme
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ10MU6
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-45 | Disordered | ||||
Sequence: MLPTKRANGAEAESSSDAPAKKARVGASASEAEAMVAGEAGGGGG | ||||||
Domain | 937-1059 | Ubiquitin-activating enzyme E1 C-terminal | ||||
Sequence: YRNSFANLAIPMFSMAEPLPPKVIKHQDMRWTIWDRWSIEGNITVAELLKWLSDKGLSAYSVSCGTSLLYNTMFPRHKDRVNKKLVDVAKEVAKVDVPAYRRHLDVVVACEDDDGNDVDIPLI |
Sequence similarities
Belongs to the ubiquitin-activating E1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,064
- Mass (Da)117,453
- Last updated2006-08-22 v1
- Checksum906AEB0A4D40CCBE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DP000009 EMBL· GenBank· DDBJ | ABF95428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK120544 EMBL· GenBank· DDBJ | BAH00064.1 EMBL· GenBank· DDBJ | mRNA |