Q108E4 · Q108E4_RUBV

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Zn2+ is necessary for the protease activity. The protease can also function efficiently with Cd2+ and Co2+.

Features

Showing features for active site, binding site, site.

131320406080100120140160180200220240260280300
Type
IDPosition(s)Description
Active site154For cysteine protease activity
Binding site177Zn2+ (UniProtKB | ChEBI)
Binding site180Zn2+ (UniProtKB | ChEBI)
Binding site229Zn2+ (UniProtKB | ChEBI)
Active site275For cysteine protease activity
Binding site275Zn2+ (UniProtKB | ChEBI)
Site303-304Cleavage; autocatalytic

GO annotations

AspectTerm
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionmetal ion binding
Molecular FunctionRNA helicase activity
Biological Processproteolysis

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Submitted names
    • Nonstructural protease protein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 4861_MILAN_ITALY_1993
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Alsuviricetes > Hepelivirales > Matonaviridae > Rubivirus > Rubivirus rubellae

Accessions

  • Primary accession
    Q108E4

Subcellular Location

Host membrane

Keywords

PTM/Processing

Post-translational modification

Non-structural polyprotein p200: Specific enzymatic cleavage by its own cysteine protease yield mature proteins p150 and p90.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-33Disordered
Domain2-303Peptidase C27
Region154-185Interaction with host CALM1
Region195-230EF-hand-like

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    313
  • Mass (Da)
    33,359
  • Last updated
    2006-08-22 v1
  • Checksum
    84DC65F4B48EE5FD
PLAPRPASDPGPLTQRSASPPAAPSGEAAAPESRGCQGCELCRYTRVTNDRVYVNLWLERDRGATGWAMRIPEVVVYGPEHLAAHFPLNHYSVLKPAEVRPPRGMCGSDMWRCRGWQGMPQVRCTPSNAHAALCRTGVPPRVSTRGDERDPNTCWLRAAANVAQAARACGAYTSAGCPRCAYGRALSEARTHEDFAALSQRWSASHADASADGTGDPLDPLMETAGCACSRVWVGSEHEAPPDHLLVSLHRAPNGPWGVVLEVRARPEGGNPTGHFVCAVGGGPRRVSDRPHLWLSVPLSRGGGTCAATDEGL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue313

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ085356
EMBL· GenBank· DDBJ
AAZ03625.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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