Q101L4 · Q101L4_BATIN

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    Q101L4

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-48Helical
Transmembrane69-93Helical
Transmembrane113-136Helical
Transmembrane148-175Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-185Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    185
  • Mass (Da)
    19,908
  • Last updated
    2009-10-13 v2
  • Checksum
    22B08E019CB26B3A
LIRAELSQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGSPDMAFPRMNNMSFWLLPPSFLLLLASAGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGISSILASINFITTIINMKPPAISQYQTPLFVWSVLVTTVLLLLALPVLAAAITMLLTDRNLNTTFF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue185

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ104896
EMBL· GenBank· DDBJ
AAZ91982.2
EMBL· GenBank· DDBJ
Genomic DNA
DQ104897
EMBL· GenBank· DDBJ
AAZ91983.2
EMBL· GenBank· DDBJ
Genomic DNA
DQ104899
EMBL· GenBank· DDBJ
AAZ91985.2
EMBL· GenBank· DDBJ
Genomic DNA
DQ104900
EMBL· GenBank· DDBJ
AAZ91986.2
EMBL· GenBank· DDBJ
Genomic DNA
DQ104901
EMBL· GenBank· DDBJ
AAZ91987.2
EMBL· GenBank· DDBJ
Genomic DNA
DQ104903
EMBL· GenBank· DDBJ
AAZ91989.2
EMBL· GenBank· DDBJ
Genomic DNA
DQ104904
EMBL· GenBank· DDBJ
AAZ91990.2
EMBL· GenBank· DDBJ
Genomic DNA
GQ449762
EMBL· GenBank· DDBJ
ACW82837.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ449763
EMBL· GenBank· DDBJ
ACW82838.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ449764
EMBL· GenBank· DDBJ
ACW82839.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ449766
EMBL· GenBank· DDBJ
ACW82841.1
EMBL· GenBank· DDBJ
Genomic DNA
GQ449777
EMBL· GenBank· DDBJ
ACW82845.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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