Q0ZPV7 · CXE1_ACTER

Function

function

Carboxylesterase acting on esters with varying acyl chain length.

Catalytic activity

Activity regulation

Is inhibited by the organophosphates paraoxon and dimethylchlorophosphate (DMCP).

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
33.3 μM4-methylumbelliferyl acetate
16.7 μM4-methylumbelliferyl butyrate
19.1 μM4-methylumbelliferyl heptanoate
6.34 μM4-methylumbelliferyl octanoate
0.117 μM4-methylumbelliferyl laureate
0.024 μM4-methylumbelliferyl palmitate

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site92-93paraoxon (UniProtKB | ChEBI); inhibitor
Active site169
Binding site169paraoxon (UniProtKB | ChEBI); inhibitor; covalent
Binding site170paraoxon (UniProtKB | ChEBI); inhibitor
Active site276
Active site306

GO annotations

AspectTerm
Molecular Functioncarboxylesterase activity

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Carboxylesterase 1
  • EC number
  • Short names
    AeCXE1

Gene names

    • Name
      CXE1

Organism names

Accessions

  • Primary accession
    Q0ZPV7

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004034821-335Carboxylesterase 1

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif90-92Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole

Sequence similarities

Belongs to the 'GDXG' lipolytic enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    335
  • Mass (Da)
    37,052
  • Last updated
    2006-08-22 v1
  • Checksum
    CA859F19267B8434
MSNDHLETTGSSDPNTNLLKYLPIVLNPDRTITRPIQIPSTAASPDPTSSSPVLTKDLALNPLHNTFVRLFLPRHALYNSAKLPLVVYFHGGGFILFSAASTIFHDFCCEMAVHAGVVIASVDYRLAPEHRLPAAYDDAMEALQWIKDSRDEWLTNFADFSNCFIMGESAGGNIAYHAGLRAAAVADELLPLKIKGLVLDEPGFGGSKRTGSELRLANDSRLPTFVLDLIWELSLPMGADRDHEYCNPTAESEPLYSFDKIRSLGWRVMVVGCHGDPMIDRQMELAERLEKKGVDVVAQFDVGGYHAVKLEDPEKAKQFFVILKKFVVDSCTTKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ279914
EMBL· GenBank· DDBJ
ABB89013.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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