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Q0WW55 · ZEUS1_ARATH

Function

function

Catalyzes the conversion of dTMP to dTDP (Probable). Involved in the regulation of DNA replication. Is essential to promote the first division of the zygote (PubMed:18036198).

Catalytic activity

Pathway

Pyrimidine metabolism; dTTP biosynthesis.

Features

Showing features for binding site.

126320406080100120140160180200220240260
TypeIDPosition(s)Description
Binding site66-74ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrion
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionnucleoside diphosphate kinase activity
Molecular Functionthymidylate kinase activity
Biological ProcessdTDP biosynthetic process
Biological ProcessdTTP biosynthetic process
Biological ProcessdUDP biosynthetic process
Biological Processembryo development ending in seed dormancy
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thymidylate kinase
  • EC number
  • Short names
    AtTMPK
  • Alternative names
    • Protein ZEUS1

Gene names

    • Name
      ZEU1
    • Ordered locus names
      At5g59440

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q0WW55
  • Secondary accessions
    • A0NAB2
    • A2P2R9
    • Q8LEB4
    • Q93ZP0

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Embryonic lethality when homozygous, due to arrest of the embryo sac development soon after fertilization.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for transit peptide, chain.

Type
IDPosition(s)Description
Transit peptide1-51Mitochondrion
ChainPRO_000043675352-263Thymidylate kinase

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in root, rosette leaves, flower buds, flowers and siliques.

Induction

Cell cycle regulated. Up-regulated at the G1/S phase transition and then decreases rapidly as cells progress into S-phase. Not up-regulated during the male and female gametophytic mitoses.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the thymidylate kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q0WW55-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    AtTMPK.1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    263
  • Mass (Da)
    29,550
  • Last updated
    2006-09-05 v1
  • MD5 Checksum
    46A2ACAEA50E4ABBD9D3ECB64E9E4CE0
MKRICSVSSVQLFSRSFRALASPRSLNYPLQCIKRSSVRMESSNFSSGVRTESSVKPRGALIVLEGLDRSGKSTQCAKLLSFLNGLGHPTELWRFPDRETSVGQMISAYLSNKSQLDDHTIHLLFSANRWEKRSLMEEKLKTGTTLIVDRYSYSGVAFSSAKGLDIEWCKAPEIGLLAPDSVLYLDISPERAAERGGYGDERYERVEFQKKVADFYQTLGDSSWKIINASDAMEEVEKKIQQVVLDQVKECTEGKPLSLLWSS

Q0WW55-2

  • Name
    2
  • Synonyms
    AtTMPK.2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F4KJ62F4KJ62_ARATHZEU1271

Features

Showing features for alternative sequence, sequence conflict.

Type
IDPosition(s)Description
Alternative sequenceVSP_0584141-39in isoform 2
Sequence conflict45in Ref. 5; AAM62744
Sequence conflict149in Ref. 3; AAL08278/AAL87366

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB025604
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CP002688
EMBL· GenBank· DDBJ
AED97188.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED97189.1
EMBL· GenBank· DDBJ
Genomic DNA
AY056422
EMBL· GenBank· DDBJ
AAL08278.1
EMBL· GenBank· DDBJ
mRNA
AY081713
EMBL· GenBank· DDBJ
AAL87366.1
EMBL· GenBank· DDBJ
mRNA
AK226501
EMBL· GenBank· DDBJ
BAE98643.1
EMBL· GenBank· DDBJ
mRNA
AY085520
EMBL· GenBank· DDBJ
AAM62744.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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