Q0WW55 · ZEUS1_ARATH
- ProteinThymidylate kinase
- GeneZEU1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids263 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Catalyzes the conversion of dTMP to dTDP (Probable). Involved in the regulation of DNA replication. Is essential to promote the first division of the zygote (PubMed:18036198).
Catalytic activity
- dTMP + ATP = dTDP + ADP
Pathway
Pyrimidine metabolism; dTTP biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 66-74 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | mitochondrion | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Molecular Function | thymidylate kinase activity | |
Biological Process | dTDP biosynthetic process | |
Biological Process | dTTP biosynthetic process | |
Biological Process | dUDP biosynthetic process | |
Biological Process | embryo development ending in seed dormancy | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThymidylate kinase
- EC number
- Short namesAtTMPK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ0WW55
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Isoform 1
Isoform 2
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Embryonic lethality when homozygous, due to arrest of the embryo sac development soon after fertilization.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transit peptide | 1-51 | Mitochondrion | |||
Chain | PRO_0000436753 | 52-263 | Thymidylate kinase | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in root, rosette leaves, flower buds, flowers and siliques.
Induction
Cell cycle regulated. Up-regulated at the G1/S phase transition and then decreases rapidly as cells progress into S-phase. Not up-regulated during the male and female gametophytic mitoses.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q0WW55-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsAtTMPK.1
- Length263
- Mass (Da)29,550
- Last updated2006-09-05 v1
- MD5 Checksum46A2ACAEA50E4ABBD9D3ECB64E9E4CE0
Q0WW55-2
- Name2
- SynonymsAtTMPK.2
- Differences from canonical
- 1-39: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F4KJ62 | F4KJ62_ARATH | ZEU1 | 271 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_058414 | 1-39 | in isoform 2 | ||
Sequence conflict | 45 | in Ref. 5; AAM62744 | |||
Sequence conflict | 149 | in Ref. 3; AAL08278/AAL87366 | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB025604 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CP002688 EMBL· GenBank· DDBJ | AED97188.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED97189.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY056422 EMBL· GenBank· DDBJ | AAL08278.1 EMBL· GenBank· DDBJ | mRNA | ||
AY081713 EMBL· GenBank· DDBJ | AAL87366.1 EMBL· GenBank· DDBJ | mRNA | ||
AK226501 EMBL· GenBank· DDBJ | BAE98643.1 EMBL· GenBank· DDBJ | mRNA | ||
AY085520 EMBL· GenBank· DDBJ | AAM62744.1 EMBL· GenBank· DDBJ | mRNA |