Q0WTY4 · VPS2B_ARATH
- ProteinVacuolar protein sorting-associated protein 2 homolog 2
- GeneVPS2.2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids222 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-III complex is probably involved in the concentration of MVB cargo (By similarity).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | ESCRT III complex | |
Biological Process | protein transport | |
Biological Process | vacuolar transport |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameVacuolar protein sorting-associated protein 2 homolog 2
- Short namesAtVPS2-2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ0WTY4
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000368196 | 1-222 | Vacuolar protein sorting-associated protein 2 homolog 2 | |||
Sequence: MNIFKKKTTPKDALRTSKREMAVATRGIEREITSLQLEEKRLVAEIKKTAKTGNEAATKILARQLVRLRQQITNLQGSRAQIRGVTTHTQALYASTSISSGMKGATKAMVAMNKQMAPTKQAKVIKDFQKQSAQLDMTIEMMSEAIDETLDKDEAEEETEDLTNQVLDEIGVGVASQLSSAPKGRIATKTAAPPASTAATNKNSESSEVDELEKRLASLRRI |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Component of the endosomal sorting required for transport complex III (ESCRT-III), composed at least of VPS2, VPS20, VPS24 and VPS32 (By similarity).
Interacts with CHMP1A, CHMP1B and VPS60-1 (PubMed:22010978).
Interacts with CHMP1A, CHMP1B and VPS60-1 (PubMed:22010978).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q0WTY4 | CHMP1A Q8LE58 | 4 | EBI-3865323, EBI-6391458 | |
BINARY | Q0WTY4 | VPS2.1 Q9SKI2 | 3 | EBI-3865323, EBI-3865345 | |
BINARY | Q0WTY4 | VPS28-1 O65421 | 4 | EBI-3865323, EBI-3865310 | |
BINARY | Q0WTY4 | VPS32.2 Q9SZE4 | 3 | EBI-3865323, EBI-3865953 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 26-83 | |||||
Sequence: RGIEREITSLQLEEKRLVAEIKKTAKTGNEAATKILARQLVRLRQQITNLQGSRAQIR | ||||||
Coiled coil | 143-222 | |||||
Sequence: SEAIDETLDKDEAEEETEDLTNQVLDEIGVGVASQLSSAPKGRIATKTAAPPASTAATNKNSESSEVDELEKRLASLRRI | ||||||
Region | 179-222 | Disordered | ||||
Sequence: SSAPKGRIATKTAAPPASTAATNKNSESSEVDELEKRLASLRRI | ||||||
Compositional bias | 206-222 | Basic and acidic residues | ||||
Sequence: SSEVDELEKRLASLRRI |
Sequence similarities
Belongs to the SNF7 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q0WTY4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length222
- Mass (Da)24,305
- Last updated2009-04-14 v2
- ChecksumC86FB65136DCE0AC
Q0WTY4-2
- Name2
- Differences from canonical
- 1-20: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8BHG3 | A0A1P8BHG3_ARATH | VPS22 | 156 | ||
A0A1P8BHG8 | A0A1P8BHG8_ARATH | VPS22 | 186 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_036803 | 1-20 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 199 | in Ref. 5; AAO64783 | ||||
Sequence: A → G | ||||||
Sequence conflict | 201 | in Ref. 2; BAE99414 and 5; AAO64783 | ||||
Sequence: N → S | ||||||
Compositional bias | 206-222 | Basic and acidic residues | ||||
Sequence: SSEVDELEKRLASLRRI |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB024024 EMBL· GenBank· DDBJ | BAB11575.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AB017065 EMBL· GenBank· DDBJ | BAB11575.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002688 EMBL· GenBank· DDBJ | AED95123.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED95124.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK227410 EMBL· GenBank· DDBJ | BAE99414.1 EMBL· GenBank· DDBJ | mRNA | ||
BT005848 EMBL· GenBank· DDBJ | AAO64783.1 EMBL· GenBank· DDBJ | mRNA |