Q0WQ41 · IP5P7_ARATH
- ProteinType IV inositol polyphosphate 5-phosphatase 7
- GeneIP5P7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids594 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Has phosphatase activity toward PtdIns(4,5)P2 and at a lower extent toward PtdIns(3,4,5)P3 but not toward Ins(1,4,5)P3 (PubMed:19473324, PubMed:21677096, PubMed:23658066).
Acts redundantly with CVP2 for maintaining vascular continuity (PubMed:19363154, PubMed:25813544).
Regulates phosphoinositide-dependent VAN3 localization (PubMed:19473324).
Functions in salt stress response by regulating reactive oxygen species (ROS) production and stress-responsive genes expression (PubMed:21677096).
Acts redundantly with CVP2 for maintaining vascular continuity (PubMed:19363154, PubMed:25813544).
Regulates phosphoinositide-dependent VAN3 localization (PubMed:19473324).
Functions in salt stress response by regulating reactive oxygen species (ROS) production and stress-responsive genes expression (PubMed:21677096).
Miscellaneous
Cvp1 and cvp2 double mutant displays high PtdIns(4,5)P2 levels.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | inositol-polyphosphate 5-phosphatase activity | |
Molecular Function | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | |
Molecular Function | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | |
Biological Process | cellular response to salt stress | |
Biological Process | leaf vascular tissue pattern formation | |
Biological Process | phosphatidylinositol dephosphorylation | |
Biological Process | regulation of reactive oxygen species metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameType IV inositol polyphosphate 5-phosphatase 7
- EC number
- Short namesAt5PTase7
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ0WQ41
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
No visible phenotype (PubMed:19473324).
Increased salt sensitivity with reduced production of reactive oxygen species (ROS) (PubMed:21677096).
Increased salt sensitivity with reduced production of reactive oxygen species (ROS) (PubMed:21677096).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 27 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000433257 | 1-594 | Type IV inositol polyphosphate 5-phosphatase 7 | |||
Sequence: MRDDKTKKSKLSWSKKMVRKWFNIKSKTEKFQADVSLPQGVEVEHRNSFSEREPCTIKKSKTEKLNKNWEQQARQRKMNYENPRIIDVQNHSIFVATWNVAGRSPPEDLNLDEWLHSSAPADIYVLGFQEIVPLNAGNVLGAEDNGPAKKWHSLIRKTLNNLPGASSACHTPSPIPVPIAEIDADFSGSSRQKNETFFNRRSFQTPSVWSMEENDPSISQPRLDRRFSVCDRVFFSHRPSDFDPSFRCGHRPSDYSRRPSDYSRPSDYYSRPSNYSRPSDVSRWGSSDDDNGPGDSPSTFLNSPGSFLGSAANENGYRTPWNSSQYCLVASKQMVGIFLTIWVKSELREHVKNMKVSCVGRGLMGYLGNKGSISISMLLHQTSFCFVCTHLTSGQKEGDELRRNSDVMEILKKTRFPRVQSSADEKSPENILQHDRVIWLGDLNYRIALSYRSAKALVEMQNWRALLENDQLRIEQKRGHVFKGWNEGKIYFPPTYKYSNNSDRYAGGDLHPKEKRRTPAWCDRILWHGEGLHQLSYVRGESRFSDHRPVYGIFSAEVESNHKRSKRTNSHSTARVEAEELLPYARGYTELTFF |
Proteomic databases
Expression
Tissue specificity
Broadly expressed in emerging organs. Mostly localized in procambium of growing organs. Restricted to vascular differentiating cells of young organs.
Developmental stage
Expressed in developing veins of late torpedo, walking stick and bent cotyledon stage embryos.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 246-261 | Basic and acidic residues | ||||
Sequence: FRCGHRPSDYSRRPSD | ||||||
Region | 246-300 | Disordered | ||||
Sequence: FRCGHRPSDYSRRPSDYSRPSDYYSRPSNYSRPSDVSRWGSSDDDNGPGDSPSTF | ||||||
Compositional bias | 266-300 | Polar residues | ||||
Sequence: SDYYSRPSNYSRPSDVSRWGSSDDDNGPGDSPSTF | ||||||
Region | 435-450 | Catalytic 1 | ||||
Sequence: DRVIWLGDLNYRIALS | ||||||
Region | 515-530 | Catalytic 2 | ||||
Sequence: KRRTPAWCDRILWHGE |
Sequence similarities
Belongs to the inositol polyphosphate 5-phosphatase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length594
- Mass (Da)68,245
- Last updated2006-09-05 v1
- ChecksumB9BBC2A961CCECAF
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 246-261 | Basic and acidic residues | ||||
Sequence: FRCGHRPSDYSRRPSD | ||||||
Compositional bias | 266-300 | Polar residues | ||||
Sequence: SDYYSRPSNYSRPSDVSRWGSSDDDNGPGDSPSTF | ||||||
Sequence conflict | 568 | in Ref. 4; CAC81920 | ||||
Sequence: T → I |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC006223 EMBL· GenBank· DDBJ | AAD15403.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002685 EMBL· GenBank· DDBJ | AEC08621.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC08622.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | ANM62725.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | ANM62726.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK228865 EMBL· GenBank· DDBJ | BAF00758.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ277885 EMBL· GenBank· DDBJ | CAC81920.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |