Q0WQ41 · IP5P7_ARATH

Function

function

Has phosphatase activity toward PtdIns(4,5)P2 and at a lower extent toward PtdIns(3,4,5)P3 but not toward Ins(1,4,5)P3 (PubMed:19473324, PubMed:21677096, PubMed:23658066).
Acts redundantly with CVP2 for maintaining vascular continuity (PubMed:19363154, PubMed:25813544).
Regulates phosphoinositide-dependent VAN3 localization (PubMed:19473324).
Functions in salt stress response by regulating reactive oxygen species (ROS) production and stress-responsive genes expression (PubMed:21677096).

Miscellaneous

Cvp1 and cvp2 double mutant displays high PtdIns(4,5)P2 levels.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functioninositol-polyphosphate 5-phosphatase activity
Molecular Functionphosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
Molecular Functionphosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Biological Processcellular response to salt stress
Biological Processleaf vascular tissue pattern formation
Biological Processphosphatidylinositol dephosphorylation
Biological Processregulation of reactive oxygen species metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Type IV inositol polyphosphate 5-phosphatase 7
  • EC number
  • Short names
    At5PTase7
  • Alternative names
    • Protein CVP2 LIKE 1
      (Protein CVL1
      )

Gene names

    • Name
      IP5P7
    • Synonyms
      CVL1
      , IPP4
    • ORF names
      F22D22.24
    • Ordered locus names
      At2g32010

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q0WQ41
  • Secondary accessions
    • Q712G2
    • Q9SKZ8

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype (PubMed:19473324).
Increased salt sensitivity with reduced production of reactive oxygen species (ROS) (PubMed:21677096).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 27 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004332571-594Type IV inositol polyphosphate 5-phosphatase 7

Proteomic databases

Expression

Tissue specificity

Broadly expressed in emerging organs. Mostly localized in procambium of growing organs. Restricted to vascular differentiating cells of young organs.

Developmental stage

Expressed in developing veins of late torpedo, walking stick and bent cotyledon stage embryos.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias246-261Basic and acidic residues
Region246-300Disordered
Compositional bias266-300Polar residues
Region435-450Catalytic 1
Region515-530Catalytic 2

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    594
  • Mass (Da)
    68,245
  • Last updated
    2006-09-05 v1
  • Checksum
    B9BBC2A961CCECAF
MRDDKTKKSKLSWSKKMVRKWFNIKSKTEKFQADVSLPQGVEVEHRNSFSEREPCTIKKSKTEKLNKNWEQQARQRKMNYENPRIIDVQNHSIFVATWNVAGRSPPEDLNLDEWLHSSAPADIYVLGFQEIVPLNAGNVLGAEDNGPAKKWHSLIRKTLNNLPGASSACHTPSPIPVPIAEIDADFSGSSRQKNETFFNRRSFQTPSVWSMEENDPSISQPRLDRRFSVCDRVFFSHRPSDFDPSFRCGHRPSDYSRRPSDYSRPSDYYSRPSNYSRPSDVSRWGSSDDDNGPGDSPSTFLNSPGSFLGSAANENGYRTPWNSSQYCLVASKQMVGIFLTIWVKSELREHVKNMKVSCVGRGLMGYLGNKGSISISMLLHQTSFCFVCTHLTSGQKEGDELRRNSDVMEILKKTRFPRVQSSADEKSPENILQHDRVIWLGDLNYRIALSYRSAKALVEMQNWRALLENDQLRIEQKRGHVFKGWNEGKIYFPPTYKYSNNSDRYAGGDLHPKEKRRTPAWCDRILWHGEGLHQLSYVRGESRFSDHRPVYGIFSAEVESNHKRSKRTNSHSTARVEAEELLPYARGYTELTFF

Sequence caution

The sequence AAD15403.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAC81920.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias246-261Basic and acidic residues
Compositional bias266-300Polar residues
Sequence conflict568in Ref. 4; CAC81920

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC006223
EMBL· GenBank· DDBJ
AAD15403.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002685
EMBL· GenBank· DDBJ
AEC08621.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC08622.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
ANM62725.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
ANM62726.1
EMBL· GenBank· DDBJ
Genomic DNA
AK228865
EMBL· GenBank· DDBJ
BAF00758.1
EMBL· GenBank· DDBJ
mRNA
AJ277885
EMBL· GenBank· DDBJ
CAC81920.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp