Q0VNE0 · ISPG_ALCBS

Function

function

Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site270[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site273[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site305[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site312[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin)
Molecular Function4-hydroxy-3-methylbut-2-enyl-diphosphate synthase activity (flavodoxin)
Molecular Functioniron ion binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
  • EC number
  • Alternative names
    • 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase

Gene names

    • Name
      ispG
    • Ordered locus names
      ABO_1860

Organism names

Accessions

  • Primary accession
    Q0VNE0

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000114331-3724-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the IspG family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    372
  • Mass (Da)
    40,625
  • Last updated
    2006-10-03 v1
  • Checksum
    6C4DE23F953F74EE
MEPEVKIERRKTRQVMVGNVPVGGDAPISVQSMTNSETCDVDATVGQIRRLQDAGVDIVRVSVPSMEAAEAFGKIRKQVDVPLVADIHYDYKIALAVAEQGVDCLRINPGNIGREDRIKAVIQCAKDKGLPIRIGVNAGSLEKELQRKYGEPTSDALVESALRHADILDRYDFQNFKVSVKASNVFMTLQAYRKLSSQLEQPLHLGVTEAGTFRSGTVKSAVALGALLMEGIGDTIRVSLAADPVEEVRVGFDILKSLNLRKKGVNIIACPSCSRQNFDVIKTVNELEARLEDINESVDLAVIGCLVNGPGEAREVDVGLTGGTPNNLAYRDGEKSHHITADDLVDELERMVRAKVKKQREDEEKGIIARSE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM286690
EMBL· GenBank· DDBJ
CAL17308.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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