Q0VGV1 · Q0VGV1_MOUSE
- ProteinGli2 protein
- GeneGli2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1540 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Publications for Q0VGV1
Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.
- CategoriesFunction, Interaction
- SourceMGI: 95728
RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.
- CategoriesPTM / Processing, Interaction
- SourceMGI: 95728
Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.
- CategoriesFunction, Interaction
- SourceMGI: 95728
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.
- CategoriesFunction, Interaction
- SourceMGI: 95728
PRMT7 methylates and suppresses GLI2 binding to SUFU thereby promoting its activation.
- AnnotationPRMT7 methylates and suppresses GLI2 binding to SUFU thereby promoting its activation.
- CategoriesPTM / Processing, Interaction
- SourceGeneRif: 14633
Genetic interaction between Gli3 and Ezh2 during limb pattern formation.
- CategoriesFunction, Interaction
- SourceMGI: 95728
PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant.
- AnnotationGli2 and Gli3 are dephosphorylated and activated in cilia and that impaired Gli2 and Gli3 processing in Ta3 mutant is at least in part due to a decrease in Gli2 and Gli3 phosphorylation.
- CategoryInteraction
The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification.
- CategoriesFunction, Interaction
- SourceMGI: 95728
Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling.
- CategoryInteraction
- SourceMGI: 95728
Ascl1/Mash1 is a novel target of Gli2 during Gli2-induced neurogenesis in P19 EC cells.
- AnnotationAscl1/Mash1 is a novel target of Gli2 during Gli2-induced neurogenesis in P19 EC cells
- CategoriesFunction, Interaction
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.
- CategoriesFunction, Interaction
- SourceMGI: 95728
Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction.
- CategoriesFunction, Interaction, Subcellular Location
- SourceMGI: 95728
Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.
- CategoryInteraction
- SourceIntAct: Q0VGV1
BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression.
- CategoryInteraction
- SourceMGI: 95728
Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function.
- AnnotationThese results suggest that Ihh regulates osteoblast differentiation of mesenchymal cells through up-regulation of the expression and function of Runx2 by Gli2.
- CategoriesFunction, Interaction
Physical and functional interactions between Zic and Gli proteins.
- CategoryInteraction
- SourceMGI: 95728