Q0VGS8 · Q0VGS8_MOUSE

  • Protein
    Glutamate receptor
  • Gene
    Gria3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

Features

Showing features for site, binding site.

1888100200300400500600700800
TypeIDPosition(s)Description
Site477Interaction with the cone snail toxin Con-ikot-ikot
Binding site502L-glutamate (UniProtKB | ChEBI)
Binding site504L-glutamate (UniProtKB | ChEBI)
Binding site509L-glutamate (UniProtKB | ChEBI)
Site659Crucial to convey clamshell closure to channel opening
Binding site680L-glutamate (UniProtKB | ChEBI)
Binding site681L-glutamate (UniProtKB | ChEBI)
Site686Interaction with the cone snail toxin Con-ikot-ikot
Binding site731L-glutamate (UniProtKB | ChEBI)
Site778Interaction with the cone snail toxin Con-ikot-ikot

GO annotations

AspectTerm
Cellular Componentpostsynaptic membrane
Molecular Functionligand-gated monoatomic ion channel activity
Molecular Functionsignaling receptor activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Glutamate receptor

Gene names

    • Name
      Gria3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q0VGS8

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Postsynaptic cell membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane545-567Helical
Transmembrane630-652Helical
Transmembrane820-842Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_502714179623-888Glutamate receptor
Disulfide bond85↔334
Disulfide bond744↔799

Keywords

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain418-795Ionotropic glutamate receptor C-terminal
Domain428-493Ionotropic glutamate receptor L-glutamate and glycine-binding

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    888
  • Mass (Da)
    100,495
  • Last updated
    2006-09-05 v1
  • Checksum
    E868C5D80E94C853
MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLGYYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDIVLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRVKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC086678
EMBL· GenBank· DDBJ
AAH86678.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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