Q0VG06 · FP100_HUMAN
- ProteinFanconi anemia core complex-associated protein 100
- GeneFAAP100
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids881 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | cytosol | |
Cellular Component | Fanconi anaemia nuclear complex | |
Cellular Component | nucleoplasm | |
Molecular Function | DNA binding | |
Biological Process | interstrand cross-link repair |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFanconi anemia core complex-associated protein 100
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ0VG06
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_032582 | 660 | in dbSNP:rs11552304 | |||
Sequence: P → L | ||||||
Natural variant | VAR_032583 | 817 | in dbSNP:rs14422 | |||
Sequence: T → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,076 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000289130 | 1-881 | UniProt | Fanconi anemia core complex-associated protein 100 | |||
Sequence: MAGAAPRVRYLAGFCCPLGGLAAGKPRVLCHEAEVFLSTGSELVYVYDQEGGLLTAAFRFPDQVWHLELLAPRRLLYALCARRGLYCLSLDHPGRSRSTSQDDRDSEDGDQPSPVIPVDPDACILPDAALCAFTLLDSVLVTLVQGPARWKMQLFEQPCPGEDPRPGGQIGEVELSSYTPPAGVPGKPAAPHFLPVLCSVSPSGSRVPHDLLGGSGGFTLEDALFGLLFGADATLLQSPVVLCGLPDGQLCCVILKALVTSRSAPGDPNALVKILHHLEEPVIFIGALKTEPQAAEAAENFLPDEDVHCDCLVAFGHHGRMLAIKASWDESGKLVPELREYCLPGPVLCAACGGGGRVYHSTPSDLCVVDLSRGSTPLGPEQPEEGPGGLPPMLCPASLNICSVVSLSASPRTHEGGTKLLALSAKGRLMTCSLDLDSEMPGPARMTTESAGQKIKELLSGIGNISERVSFLKKAVDQRNKALTSLNEAMNVSCALLSSGTGPRPISCTTSTTWSRLQTQDVLMATCVLENSSSFSLDQGWTLCIQVLTSSCALDLDSACSAITYTIPVDQLGPGARREVTLPLGPGENGGLDLPVTVSCTLFYSLREVVGGALAPSDSEDPFLDECPSDVLPEQEGVCLPLSRHTVDMLQCLRFPGLAPPHTRAPSPLGPTRDPVATFLETCREPGSQPAGPASLRAEYLPPSVASIKVSAELLRAALKDGHSGVPLCCATLQWLLAENAAVDVVRARALSSIQGVAPDGANVHLIVREVAMTDLCPAGPIQAVEIQVESSSLADICRAHHAVVGRMQTMVTEQATQGSSAPDLRVQYLRQIHANHETLLREVQTLRDRLCTEDEASSCATAQRLLQVYRQLRHPSLILL | |||||||
Modified residue | 667 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 667 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 672 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 688 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and FAAP100. Forms a subcomplex with FANCB and FANCL.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q0VG06 | BOLA3 Q53S33 | 2 | EBI-2557990, EBI-12086950 | |
BINARY | Q0VG06 | CFTR P13569 | 4 | EBI-2557990, EBI-349854 | |
BINARY | Q0VG06 | FANCA O15360 | 4 | EBI-2557990, EBI-81570 | |
BINARY | Q0VG06 | FANCB Q8NB91 | 4 | EBI-2557990, EBI-2557983 | |
BINARY | Q0VG06 | GRK7 Q8WTQ7 | 2 | EBI-2557990, EBI-6423032 | |
BINARY | Q0VG06-3 | AARSD1 Q9BTE6-2 | 3 | EBI-10226932, EBI-9357295 | |
BINARY | Q0VG06-3 | HOXA1 P49639 | 3 | EBI-10226932, EBI-740785 | |
BINARY | Q0VG06-3 | MDFI Q99750 | 3 | EBI-10226932, EBI-724076 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 94-119 | Disordered | ||||
Sequence: GRSRSTSQDDRDSEDGDQPSPVIPVD | ||||||
Compositional bias | 96-110 | Basic and acidic residues | ||||
Sequence: SRSTSQDDRDSEDGD |
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q0VG06-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Synonymsb
- Length881
- Mass (Da)93,433
- Last updated2010-11-30 v3
- ChecksumC586768FB1C7ABD2
Q0VG06-2
- Name2
Q0VG06-3
- Name3
- Synonymsa
- Differences from canonical
- 1-151: Missing
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_038262 | 1-151 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_025922 | 1-628 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 96-110 | Basic and acidic residues | ||||
Sequence: SRSTSQDDRDSEDGD | ||||||
Alternative sequence | VSP_025923 | 629-665 | in isoform 2 | |||
Sequence: SDVLPEQEGVCLPLSRHTVDMLQCLRFPGLAPPHTRA → MPASFPMLRCARSPCWTVCWSPWCRALPDGRCSCLSS | ||||||
Sequence conflict | 654 | in Ref. 3; BC008883 | ||||
Sequence: R → C |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK024644 EMBL· GenBank· DDBJ | BAB14944.1 EMBL· GenBank· DDBJ | mRNA | ||
AK025828 EMBL· GenBank· DDBJ | BAB15251.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AC137896 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR978826 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
BC001724 EMBL· GenBank· DDBJ | AAH01724.1 EMBL· GenBank· DDBJ | mRNA | ||
BC008883 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
BC021968 EMBL· GenBank· DDBJ | AAH21968.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC117139 EMBL· GenBank· DDBJ | AAI17140.1 EMBL· GenBank· DDBJ | mRNA | ||
BC117141 EMBL· GenBank· DDBJ | AAI17142.1 EMBL· GenBank· DDBJ | mRNA | ||
AL834374 EMBL· GenBank· DDBJ | CAD39037.2 EMBL· GenBank· DDBJ | mRNA | Different initiation |