Q0VD16 · Q0VD16_BOVIN
- ProteinDual specificity mitogen-activated protein kinase kinase 1
- GeneMAP2K1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids393 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | early endosome | |
Cellular Component | focal adhesion | |
Cellular Component | late endosome | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Cellular Component | spindle pole body | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | MAPK cascade | |
Biological Process | neuron differentiation | |
Biological Process | regulation of early endosome to late endosome transport | |
Biological Process | regulation of Golgi inheritance | |
Biological Process | regulation of stress-activated MAPK cascade |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDual specificity mitogen-activated protein kinase kinase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionQ0VD16
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-27 | Disordered | ||||
Sequence: MPKKKPTPIQLNPAPDGSAVNGTSSAE | ||||||
Domain | 68-361 | Protein kinase | ||||
Sequence: FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI |
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length393
- Mass (Da)43,439
- Last updated2008-01-15 v2
- Checksum0344118FFC842D51
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9SXR1 | A0AAA9SXR1_BOVIN | MAP2K1 | 317 | ||
A0AAA9TBR2 | A0AAA9TBR2_BOVIN | MAP2K1 | 234 | ||
A0AAA9TQF1 | A0AAA9TQF1_BOVIN | MAP2K1 | 284 | ||
A0AAA9TQR1 | A0AAA9TQR1_BOVIN | MAP2K1 | 414 | ||
A0AAA9S4V4 | A0AAA9S4V4_BOVIN | MAP2K1 | 379 | ||
A0AAA9TXV4 | A0AAA9TXV4_BOVIN | MAP2K1 | 344 | ||
A0AAA9TUS2 | A0AAA9TUS2_BOVIN | MAP2K1 | 350 | ||
A0AAA9S087 | A0AAA9S087_BOVIN | MAP2K1 | 345 | ||
A0AAA9S6C0 | A0AAA9S6C0_BOVIN | MAP2K1 | 377 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC119886 EMBL· GenBank· DDBJ | AAI19887.2 EMBL· GenBank· DDBJ | mRNA |