Q0VBK8 · Q0VBK8_MOUSE
- ProteinCyclin-dependent kinase 6
- GeneCdk6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids326 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Publications for Q0VBK8
Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.
- CategoryFunction
- SourceMGI: 1277162
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.
- CategoriesSequences, Expression
- SourceMGI: 1277162
- PubMed
- Europe PMC
- Cell Growth Differ 8:1139-1150 ()
Mapped toIdentification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
- CategoriesSequences, Interaction
- SourceMGI: 1277162
Cloning and characterization of murine p16INK4a and p15INK4b genes.
- CategorySequences
- SourceMGI: 1277162
- PubMed
- Europe PMC
- Oncogene 11:635-645 ()
Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells.
- AnnotationKinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells.
- CategoryNames
CDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver.
- AnnotationCDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver.
- SourceGeneRif: 12571
CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.
- AnnotationCDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.
- CategoriesStructure, Subcellular Location
- SourceGeneRif: 12571
CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue.
- AnnotationCDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue.
- CategoryFunction
- SourceGeneRif: 12571
Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.
- CategoriesFunction, Interaction
- SourceMGI: 1277162
Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
- AnnotationInhibition of CDK4/6 regulates AD pathology neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
- CategoryFunction
MiR-21 participates in LPS-induced myocardial injury by targeting Bcl-2 and CDK6.
- AnnotationMiR-21 participates in LPS-induced myocardial injury by targeting Bcl-2 and CDK6.
- CategoriesFunction, Expression
- SourceGeneRif: 12571
RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes.
- AnnotationRB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes.
- CategoryFunction
- SourceGeneRif: 12571
YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling.
- AnnotationYAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling.
- CategoryFunction
T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses <i>In Vivo</i>.
- AnnotationT Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo.
- CategoriesFunction, Phenotypes & Variants
MSCs‑derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6.
- AnnotationMSCsderived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6.
- CategoriesFunction, Expression
- SourceGeneRif: 12571
Mapped toCDK6 Is a Therapeutic Target in Myelofibrosis.
- AnnotationCDK6 Is a Therapeutic Target in Myelofibrosis.
- CategoriesFunction, Phenotypes & Variants
Inhibition of CDK4/6 kinases causes production of aneuploid oocytes by inactivating the spindle assembly checkpoint and accelerating first meiotic progression.
- AnnotationInhibition of CDK4/6 kinases causes production of aneuploid oocytes by inactivating the spindle assembly checkpoint and accelerating first meiotic progression.
- CategoryFunction
- SourceGeneRif: 12571
miR‑449a‑5p suppresses CDK6 expression to inhibit cardiomyocyte proliferation.
- AnnotationmiR449a5p suppresses CDK6 expression to inhibit cardiomyocyte proliferation.
- CategoriesFunction, Expression
CDK4/6 Dependence of Cyclin D1-Driven Parathyroid Neoplasia in Transgenic Mice.
- AnnotationCDK4/6 Dependence of Cyclin D1-Driven Parathyroid Neoplasia in Transgenic Mice.
- CategoryFunction
- SourceGeneRif: 12571
Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.
- AnnotationInducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.
- CategoriesFunction, Phenotypes & Variants
CDK6 inhibition targeted by miR-378a-3p protects against intestinal injury induced by ionizing radiation.
- AnnotationCDK6 inhibition targeted by miR-378a-3p protects against intestinal injury induced by ionizing radiation.
- CategoryFunction
- SourceGeneRif: 12571