Q0VBK8 · Q0VBK8_MOUSE
- ProteinCyclin-dependent kinase 6
- GeneCdk6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids326 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Publications for Q0VBK8
Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.
- CategoryFunction
- SourceMGI: 1277162
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.
- CategoriesSequences, Expression
- SourceMGI: 1277162
- PubMed
- Europe PMC
- Cell Growth Differ 8:1139-1150 ()
Mapped toNovel CDC2-related protein kinases produced in murine hematopoietic stem cells.
- CategorySequences
- SourceMGI: 1277162
Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
- CategoriesSequences, Interaction
- SourceMGI: 1277162
Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D- dependent kinases CDK4 and CDK6.
- CategoriesSequences, Interaction
- SourceMGI: 1277162
Cloning and characterization of murine p16INK4a and p15INK4b genes.
- CategorySequences
- SourceMGI: 1277162
- PubMed
- Europe PMC
- Oncogene 11:635-645 ()
Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells.
- AnnotationKinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells.
- CategoryNames
- SourceGeneRif: 12571
Genetic determinants of micronucleus formation in vivo.
- CategoryNames
- SourceMGI: 1277162
CDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver.
- AnnotationCDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver.
- SourceGeneRif: 12571
miR-195b is required for proper cellular homeostasis in the elderly.
- CategorySequences
- SourceMGI: 1277162
CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.
- AnnotationCDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.
- CategoriesStructure, Subcellular Location
- SourceGeneRif: 12571
CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue.
- AnnotationCDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue.
- CategoryFunction
- SourceGeneRif: 12571
Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
- AnnotationInhibition of CDK4/6 regulates AD pathology neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
- CategoryFunction
A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1277162
A SOX17-PDGFB signaling axis regulates aortic root development.
- CategoryFunction
- SourceMGI: 1277162
MiR-21 participates in LPS-induced myocardial injury by targeting Bcl-2 and CDK6.
- AnnotationMiR-21 participates in LPS-induced myocardial injury by targeting Bcl-2 and CDK6.
- CategoriesFunction, Expression
- SourceGeneRif: 12571
RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes.
- AnnotationRB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes.
- CategoryFunction
- SourceGeneRif: 12571
Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.
- CategoriesInteraction, Subcellular Location
- SourceMGI: 1277162