A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding.Wang L., Park J.Y., Liu F., Olesen K.M., Hou S., Peng J.C., Infield J., Levesque A.C., Wang Y.D.[...], Han Y.G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCProc Natl Acad Sci U S A 119:e2206147119-e2206147119 (2022)Mapped to62
T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses <i>In Vivo</i>.Klein K., Witalisz-Siepracka A., Gotthardt D., Agerer B., Locker F., Grausenburger R., Knab V.M., Bergthaler A., Sexl V.View abstractAnnotationT Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 12571, MGI: 1277162PubMedEurope PMCFront Immunol 12:650977-650977 (2021)Mapped to6
CDK6 Is a Therapeutic Target in Myelofibrosis.Dutta A., Nath D., Yang Y., Le B.T., Mohi G.View abstractAnnotationCDK6 Is a Therapeutic Target in Myelofibrosis.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 12571, MGI: 1277162PubMedEurope PMCCancer Res 81:4332-4345 (2021)Mapped to7
Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.Maurer B., Brandstoetter T., Kollmann S., Sexl V., Prchal-Murphy M.View abstractAnnotationInducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 12571, MGI: 1277162PubMedEurope PMCHaematologica 106:2624-2632 (2021)Mapped to17
The Role of CDKs and CDKIs in Murine Development.Campbell G.J., Hands E.L., Van de Pette M.View abstractCategoriesNames, Function, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCInt J Mol Sci 21:E5343-E5343 (2020)Mapped to87
CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia.Schmoellerl J., Barbosa I.A.M., Eder T., Brandstoetter T., Schmidt L., Maurer B., Troester S., Pham H.T.T., Sagarajit M.[...], Grebien F.View abstractAnnotationCDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 12571PubMedEurope PMCBlood 136:387-400 (2020)Mapped to4
CDK6 coordinates pii>JAK2pi/i> pisup>pii>V617Fpi/i>pi/sup> mutant MPN via NF-kappaB and apoptotic networks.Uras I.Z., Maurer B., Nivarthi H., Jodl P., Kollmann K., Prchal-Murphy M., Milosevic Feenstra J.D., Zojer M., Lagger S.[...], Sexl V.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCBlood 133:1677-1690 (2019)Mapped to9
Ablation of cdk4 and cdk6 affects proliferation of basal progenitor cells in the developing dorsal and ventral forebrain.Grison A., Gaiser C., Bieder A., Baranek C., Atanasoski S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCDev Neurobiol 78:660-670 (2018)Mapped to30
Loss of Neuroglobin Expression Alters Cdkn1a/Cdk6-Expression Resulting in Increased Proliferation of Neural Stem Cells.Luyckx E., Van Leuven W., Andre D., Quarta A., Reekmans K., Fransen E., Moens L., Hankeln T., Ponsaerts P., Dewilde S.View abstractAnnotationThe downregulation of Cdkn1a and the upregulation of Cdk6.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 12571, MGI: 1277162PubMedEurope PMCStem Cells Dev 27:378-390 (2018)Mapped to13
Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.Zhou L., Liu J., Xiang M., Olson P., Guzzetta A., Zhang K., Moskowitz I.P., Xie L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCProc Natl Acad Sci U S A 114:E1422-E1431 (2017)Mapped to54
Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung.Wang X., Wang Y., Snitow M.E., Stewart K.M., Li S., Lu M., Morrisey E.E.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCDev Biol 414:161-169 (2016)Mapped to99+
Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development.Matsumoto S., Kiryu-Seo S., Kiyama H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCJ Neurosci 36:4744-4757 (2016)Mapped to99+
Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.Uras I.Z., Walter G.J., Scheicher R., Bellutti F., Prchal-Murphy M., Tigan A.S., Valent P., Heidel F.H., Kubicek S.[...], Sexl V.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCBlood 127:2890-2902 (2016)Mapped to16
Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis.Wu J., Bao J., Kim M., Yuan S., Tang C., Zheng H., Mastick G.S., Xu C., Yan W.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCProc Natl Acad Sci U S A 111:E2851-7 (2014)Mapped to99+
Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression.Ishimura A., Minehata K., Terashima M., Kondoh G., Hara T., Suzuki T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCDevelopment 139:749-759 (2012)Mapped to41
A conditional knockout resource for the genome-wide study of mouse gene function.Skarnes W.C., Rosen B., West A.P., Koutsourakis M., Bushell W., Iyer V., Mujica A.O., Thomas M., Harrow J.[...], Bradley A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCNature 474:337-342 (2011)Mapped to99+
CDK6 kinase activity is required for thymocyte development.Hu M.G., Deshpande A., Schlichting N., Hinds E.A., Mao C., Dose M., Hu G.F., Van Etten R.A., Gounari F., Hinds P.W.View abstractAnnotationan important role for CDK6 kinase activity in thymocyte development that operates partially through modulating Notch target gene expression.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 12571, MGI: 1277162PubMedEurope PMCBlood 117:6120-6131 (2011)Cited in1Mapped to62
Microglial/macrophage GRK2 determines duration of peripheral IL-1beta- induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.Willemen H.L.D.M., Eijkelkamp N., Wang H., Dantzer R., Dorn G.W., Kelley K.W., Heijnen C.J., Kavelaars A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCPain 150:550-560 (2010)Mapped to21
Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts.Michaud K., Solomon D.A., Oermann E., Kim J.S., Zhong W.Z., Prados M.D., Ozawa T., James C.D., Waldman T.View abstractAnnotationcyclin-dependent kinase 4 and 6 inhibition arrests the growth of glioblastoma multiforme intracranial xenograftsCategoriesFunction, Phenotypes & VariantsSourceGeneRif: 12571PubMedEurope PMCCancer Res 70:3228-3238 (2010)Mapped to11
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.Zambrowicz B.P., Abuin A., Ramirez-Solis R., Richter L.J., Piggott J., BeltrandelRio H., Buxton E.C., Edwards J., Finch R.A.[...], Sands A.T.View abstractCategoryPhenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 100:14109-14114 (2003)Cited in1Mapped to99+