The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]TissueBrainCategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]CategorySequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
Control of cell cycle gene expression in bone development and during c- Fos-induced osteosarcoma formation.Sunters A., McCluskey J., Grigoriadis A.E.View abstractCategoryExpressionSourceMGI: 1277162PubMedEurope PMCDev Genet 22:386-397 (1998)Mapped to39
Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.Ahuja H.S., Zhu Y., Zakeri Z.View abstractCategoryFunctionSourceMGI: 1277162PubMedEurope PMCDev Genet 21:258-267 (1997)Mapped to45
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.Zindy F., Soares H., Herzog K.H., Morgan J., Sherr C.J., Roussel M.F.View abstractCategoriesSequences, ExpressionSourceMGI: 1277162PubMedEurope PMCCell Growth Differ 8:1139-1150 (1997)Mapped to37
Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.Ershler M.A., Nagorskaya T.V., Visser J.W.M., Belyavsky A.V.View abstractCategorySequencesSourceMGI: 1277162PubMedEurope PMCGene 124:305-306 (1993)Cited in9Mapped to42
Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.Chan F.K.M., Zhang J., Cheng L., Shapiro D.N., Winoto A.View abstractCategoriesSequences, InteractionSourceMGI: 1277162PubMedEurope PMCMol. Cell. Biol. 15:2682-2688 (1995)Cited in2Mapped to19
Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D- dependent kinases CDK4 and CDK6.Hirai H., Roussel M.F., Kato J.-Y., Ashmun R.A., Sherr C.J.View abstractCategoriesSequences, InteractionSourceMGI: 1277162PubMedEurope PMCMol. Cell. Biol. 15:2672-2681 (1995)Cited in2Mapped to52
Cloning and characterization of murine p16INK4a and p15INK4b genes.Quelle D.E., Ashmun R.A., Hannon G.J., Rehberger P.A., Trono D., Richter K.H., Walker C., Beach D., Sherr C.J., Serrano M.View abstractCategorySequencesSourceMGI: 1277162PubMedEurope PMCOncogene 11:635-645 (1995)Cited in21Mapped to19
Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.Barao S., Xu Y., Llongueras J.P., Vistein R., Goff L., Nielsen K.J., Bae B.I., Smith R.S., Walsh C.A.[...], Muller U.View abstractSourceMGI: 1277162PubMedEurope PMCNat Commun 15:8043-8043 (2024)Mapped to99+
Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells.Mayer I.M., Doma E., Klampfl T., Prchal-Murphy M., Kollmann S., Schirripa A., Scheiblecker L., Zojer M., Kunowska N.[...], Kollmann K.View abstractAnnotationKinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells.CategoryNamesSourceGeneRif: 12571PubMedEurope PMCBlood 144:156-170 (2024)Mapped to4
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoryNamesSourceMGI: 1277162PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
CDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver.Hu A.J., Li W., Dinh C., Zhang Y., Hu J.K., Daniele S.G., Hou X., Yang Z., Asara J.M.[...], Hu M.G.View abstractAnnotationCDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver.SourceGeneRif: 12571PubMedEurope PMCNat Commun 15:1091-1091 (2024)Mapped to3
miR-195b is required for proper cellular homeostasis in the elderly.Munoz-Gallardo M.D.M., Garcia-Padilla C., Vicente-Garcia C., Carvajal J., Arenega A., Franco D.View abstractCategorySequencesSourceMGI: 1277162PubMedEurope PMCSci Rep 14:810-810 (2024)Mapped to99+
CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.Nayyar N., de Sauvage M.A., Chuprin J., Sullivan E.M., Singh M., Torrini C., Zhang B.S., Bandyopadhyay S., Daniels K.A.[...], Brastianos P.K.View abstractAnnotationCDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.CategoriesStructure, Subcellular LocationSourceGeneRif: 12571PubMedEurope PMCClin Cancer Res 30:420-435 (2024)Mapped to3
Maternal <i>Toxoplasma gondii</i> infection affects proliferation, differentiation and cell cycle regulation of retinal neural progenitor cells in mouse embryo.de Campos V.S., Magalhaes C.F., da Rosa B.G., Dos Santos C.M., Fragel-Madeira L., Figueiredo D.P., Calaza K.C., Adesse D.View abstractCategoriesNames, ExpressionSourceMGI: 1277162PubMedEurope PMCFront Cell Neurosci 17:1211446-1211446 (2023)Mapped to32
CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue.Portales A.E., Miguel I., Rodriguez M.J., Novaro V., Gambaro S.E., Giovambattista A.View abstractAnnotationCDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue.CategoryFunctionSourceGeneRif: 12571PubMedEurope PMCLife Sci 322:121652-121652 (2023)Mapped to10
Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.Gao X., Wu Y., Chick J.M., Abbott A., Jiang B., Wang D.J., Comte-Walters S., Johnson R.H., Oberholtzer N.[...], Wang H.View abstractSourceMGI: 1277162PubMedEurope PMCCell Rep 42:112314-112314 (2023)Mapped to43
Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.Lee H.J., Hoe H.S.View abstractAnnotationInhibition of CDK4/6 regulates AD pathology neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.CategoryFunctionSourceGeneRif: 12571, MGI: 1277162PubMedEurope PMCPharmacol Res 190:106725-106725 (2023)Mapped to17
Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming.Chong D., Gu Y., Zhang T., Xu Y., Bu D., Chen Z., Xu N., Li L., Zhu X.[...], Li C.View abstractCategoryFunctionSourceMGI: 1277162PubMedEurope PMCCell Discov 8:106-106 (2022)Mapped to99+
A kinase-independent function of cyclin-dependent kinase 6 promotes outer radial glia expansion and neocortical folding.Wang L., Park J.Y., Liu F., Olesen K.M., Hou S., Peng J.C., Infield J., Levesque A.C., Wang Y.D.[...], Han Y.G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1277162PubMedEurope PMCProc Natl Acad Sci U S A 119:e2206147119-e2206147119 (2022)Mapped to62
A SOX17-PDGFB signaling axis regulates aortic root development.Lu P., Wang P., Wu B., Wang Y., Liu Y., Cheng W., Feng X., Yuan X., Atteya M.M.[...], Zhou B.View abstractCategoryFunctionSourceMGI: 1277162PubMedEurope PMCNat Commun 13:4065-4065 (2022)Mapped to99+
MiR-21 participates in LPS-induced myocardial injury by targeting Bcl-2 and CDK6.Li Y., Sun G., Wang L.View abstractAnnotationMiR-21 participates in LPS-induced myocardial injury by targeting Bcl-2 and CDK6.CategoriesFunction, ExpressionSourceGeneRif: 12571PubMedEurope PMCInflamm Res 71:205-214 (2022)Mapped to3
RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes.Pesch A.M., Hirsh N.H., Michmerhuizen A.R., Jungles K.M., Wilder-Romans K., Chandler B.C., Liu M., Lerner L.M., Nino C.A.[...], Speers C.W.View abstractAnnotationRB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes.CategoryFunctionSourceGeneRif: 12571PubMedEurope PMCJCI Insight 7:e154402-e154402 (2022)Mapped to10
HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly.Sharma D., Mirando A.J., Leinroth A., Long J.T., Karner C.M., Hilton M.J.View abstractCategoryFunctionSourceMGI: 1277162PubMedEurope PMCPLoS Genet 17:e1009982-e1009982 (2021)Mapped to99+