Q0VB73 · Q0VB73_MOUSE
- ProteinGranulocyte colony-stimulating factor
- GeneCsf3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids208 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Publications for Q0VB73
Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia.
- CategoriesSequences, Phenotypes & Variants
- SourceMGI: 1339751
- PubMed
- Europe PMC
- Blood 92:32-39 ()
Mapped toEssential roles for granulocyte-macrophage colony-stimulating factor (GM- CSF) and G-CSF in the sustained hematopoietic response of Listeria monocytogenes-infected mice.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1339751
- PubMed
- Europe PMC
- Blood 91:863-869 ()
Mapped toMice lacking both granulocyte colony-stimulating factor (CSF) and granulocyte-macrophage CSF have impaired reproductive capacity, perturbed neonatal granulopoiesis, lung disease, amyloidosis, and reduced long-term survival.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1339751
- PubMed
- Europe PMC
- Blood 90:3037-3049 ()
Mapped toGenetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor.
- CategoriesSequences, Phenotypes & Variants
- SourceMGI: 1339751
- PubMed
- Europe PMC
- Blood 89:2736-2744 ()
Mapped toSelective inhibition of resistance to hemopoietic allografts but not rejection to a natural killer cell sensitive tumor in transgenic mice for granulocyte colony stimulating factor.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1339751
Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1339751
- PubMed
- Europe PMC
- Blood 84:1737-1746 ()
Mapped toGCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration.
- AnnotationGCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells infiltration.
- CategoriesFunction, Phenotypes & Variants
Neutrophil Elastase Damages the Pulmonary Endothelial Glycocalyx in Lipopolysaccharide-Induced Experimental Endotoxemia.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1339751
Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1339751
Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.
- AnnotationThese studies suggest that G-CSF may play a central and unforeseen pathogenic role in COPD and its complex comorbidities and identify G-CSF and its regulators as potential therapeutic targets.
- CategoriesFunction, Phenotypes & Variants
Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome.
- CategoriesFunction, Expression, Phenotypes & Variants
- SourceMGI: 1339751
IFNgamma inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis.
- AnnotationThe opposing roles of G-CSF and IFNgamma in regulation of innate inflammatory responses in a murine viral encephalitis model reveal G-CSF as a potential therapeutic target.
- CategoriesFunction, Phenotypes & Variants
Role of G-CSF in monophosphoryl lipid A-mediated augmentation of neutrophil functions after burn injury.
- Annotationfindings provide convincing evidence that monophosphoryl lipid A-induced G-CSF facilitates early expansion mobilization and recruitment of neutrophils to the site of infection after burn injury
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 12985
Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production.
- Annotationconstitutive activation of the NF-kappaB pathway in CAIX-depleted cells restored G-CSF secretion
- CategoriesFunction, Expression, Phenotypes & Variants
- SourceGeneRif: 12985
Modification of T cell responses by stem cell mobilization requires direct signaling of the T cell by G-CSF and IL-10.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1339751
Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization.
- AnnotationAfter deletion of Pten in mice lacking G-CSF the splenomegaly myeloproliferative disease and splenic hematopoietic stem cell accumulation are rescued.
- CategoriesFunction, Phenotypes & Variants
Upregulation of TLR2 expression on G-CSF-mobilized peripheral blood stem cells is responsible for their rapid engraftment after allogeneic hematopoietic stem cell transplantation.
- AnnotationTLR2 signaling in G-CSF mobilized PBSCs correlates with their ability to rapidly differentiate into myeloid cells resulting in improved engraftment
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 12985
Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.
- AnnotationCot/tpl2 has an important role in the NGF G-CSF and GM-CSF production and myeloperoxidase activity in the acute inflammatory response process and its implication in inflammatory hypernociception
- CategoriesFunction, Phenotypes & Variants
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.
- CategoriesSequences, Phenotypes & Variants
- SourceMGI: 1339751
The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice.
- AnnotationThis study confirmed G-CSF as an essential neurotrophic factor and point to a role in the proliferation differentiation and functional integration of neural cells necessary for the structural and functional integrity of the hippocampal formation.
- CategoriesFunction, Phenotypes & Variants
Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.
- AnnotationTACE is associated with a regulation of IL-17 and G-CSF expression in vivo
- CategoriesFunction, Phenotypes & Variants
Mice lacking both G-CSF and IL-6 are more susceptible to Candida albicans infection: critical role of neutrophils in defense against Candida albicans.
- AnnotationG-CSF and IL-6 have roles in neutrophil defense against Candida albicans infection
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 12985
IL6/sIL6R complex contributes to emergency granulopoietic responses in G- CSF- and GM-CSF-deficient mice.
- AnnotationNeutrophil promoting activity (NPA) production by mice defective for both G-CSF and GM-CSF uncovers an alternative pathway to granulocyte production which is activated after exposure to pathogens.
- CategoriesFunction, Phenotypes & Variants
Macrophage-colony stimulating factor is required for the production of neutrophil-promoting activity by mouse embryo fibroblasts deficient in G- CSF and GM-CSF.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1339751