Q0VAM2 · RGF1B_HUMAN

  • Protein
    Ras-GEF domain-containing family member 1B
  • Gene
    RASGEF1B
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentearly endosome
Cellular Componentlate endosome
Cellular Componentmidbody
Cellular Componentplasma membrane
Molecular Functionguanyl-nucleotide exchange factor activity
Biological ProcessRas protein signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ras-GEF domain-containing family member 1B
  • Alternative names
    • GPI gamma-4

Gene names

    • Name
      RASGEF1B
    • Synonyms
      GPIG4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q0VAM2
  • Secondary accessions
    • Q0VAM1
    • Q4W5L7
    • Q4W5M3
    • Q96MY8

Proteomes

Organism-specific databases

Subcellular Location

Early endosome
Late endosome
Midbody
Note: May shuttle between early and late endosomes (By similarity).
Localizes to midbody at telophase

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 445 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002976381-473Ras-GEF domain-containing family member 1B

Proteomic databases

PTM databases

Expression

Induction

Up-regulated in macrophages stimulated with IFNG, GPI-mucins or bacterial lipopolysaccharides (LPS).

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with Ras family proteins (By similarity).
Interacts with CCDC124 during cytokinesis

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q0VAM2-3BAZ2B Q9UIF83EBI-12013954, EBI-741542
BINARY Q0VAM2-3PDLIM7 Q9NR123EBI-12013954, EBI-350517
BINARY Q0VAM2-3PLEKHF2 Q9H8W43EBI-12013954, EBI-742388
BINARY Q0VAM2-3TSGA10IP Q3SY003EBI-12013954, EBI-10241197

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain34-164N-terminal Ras-GEF
Domain204-452Ras-GEF

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q0VAM2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    473
  • Mass (Da)
    55,359
  • Last updated
    2007-08-21 v2
  • MD5 Checksum
    8A4F6CC2DF454593C3087F939A29FD5B
MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV

Q0VAM2-2

Q0VAM2-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D6RE71D6RE71_HUMANRASGEF1B232
A0A1B0GVA7A0A1B0GVA7_HUMANRASGEF1B560
A0A1B0GW78A0A1B0GW78_HUMANRASGEF1B119
Q8N437Q8N437_HUMANRASGEF1B210
A0A0G2JLL4A0A0G2JLL4_HUMANRASGEF1B74

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_02731360-100in isoform 2
Alternative sequenceVSP_027314147in isoform 2 and isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK056257
EMBL· GenBank· DDBJ
BAB71130.1
EMBL· GenBank· DDBJ
mRNA
AC006287
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC093747
EMBL· GenBank· DDBJ
AAY40982.1
EMBL· GenBank· DDBJ
Genomic DNA
AC093618
EMBL· GenBank· DDBJ
AAY41054.1
EMBL· GenBank· DDBJ
Genomic DNA
BC121003
EMBL· GenBank· DDBJ
AAI21004.1
EMBL· GenBank· DDBJ
mRNA
BC121004
EMBL· GenBank· DDBJ
AAI21005.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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