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Q0VA29 · Q0VA29_XENTR

Function

function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionendothelin receptor activity
Biological Processenteric nervous system development
Biological Processregulation of blood pressure
Biological Processvasoconstriction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endothelin-1 receptor
  • Alternative names
    • Endothelin receptor type A

Gene names

    • Name
      ednra
    • Synonyms
      Ednra
      , ednra-a
      , ednra-b
      , endo-r
      , eta
      , etar
      , etax
      , etra

Organism names

Accessions

  • Primary accession
    Q0VA29
  • Secondary accessions
    • F6WIF1
    • F7AXV7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane69-94Helical
Transmembrane106-131Helical
Transmembrane190-215Helical
Transmembrane245-271Helical
Transmembrane292-312Helical
Transmembrane332-360Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-24
ChainPRO_503320634525-414Endothelin-1 receptor

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with HDAC7 and KAT5.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain85-357G-protein coupled receptors family 1 profile

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    414
  • Mass (Da)
    47,023
  • Last updated
    2006-09-05 v1
  • MD5 Checksum
    B27F5DED262B0F9B5F3FB9D1734DF695
MGGDILRFTVLVVLAGIAVSSSFGEHYQNRTDANTDFTMLNRSYTPPVRRMNRSELCPEKTKINHVFKYINTILSCAIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPIIVFKLLAQRWPFDQSPVGSFLCKLVPFIQKASVGITVLNLCALSVDRYRAVASWSRVQGSGIPLITAIEIISIWVLSFVLAVPEAIGFVMVPFEYRGEEFRTCMFHATSPFMMFYKVAKDWWLFGCYFCVPLACTGVFYTMMTCEMLHQRKGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRIIKKTIYNELDPSRCELLSFLLVMDFISINLAALNSCINPIALYFVSKKFKNCFQSCLCCCCQSKTHINTAPMNVTSIQWKNHEQNYYGADRSIHKDSIN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC121283
EMBL· GenBank· DDBJ
AAI21284.1
EMBL· GenBank· DDBJ
mRNA
DQ865481
EMBL· GenBank· DDBJ
ABI95144.1
EMBL· GenBank· DDBJ
mRNA
DQ865482
EMBL· GenBank· DDBJ
ABI95145.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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