Q0V9W0 · GPC1_XENTR
- ProteinGlypican-1
- Genegpc1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids554 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Cell surface proteoglycan that bears heparan sulfate.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | extracellular region | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Biological Process | regulation of signal transduction |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlypican-1
- Cleaved into 1 chains
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionQ0V9W0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Secreted glypican-1
Keywords
- Cellular component
PTM/Processing
Features
Showing features for propeptide, signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Propeptide | PRO_0000417512 | ?-554 | Removed in mature form | ||
Signal | 1-21 | ||||
Chain | PRO_0000417510 | 22-? | Glypican-1 | ||
Chain | PRO_0000417511 | 22-? | Secreted glypican-1 | ||
Disulfide bond | 32↔68 | ||||
Disulfide bond | 62↔256 | ||||
Disulfide bond | 69↔259 | ||||
Glycosylation | 79 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 116 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 191↔343 | ||||
Disulfide bond | 246↔279 | ||||
Disulfide bond | 268↔415 | ||||
Disulfide bond | 272↔401 | ||||
Glycosylation | 486 | O-linked (Xyl...) (heparan sulfate) serine | |||
Glycosylation | 488 | O-linked (Xyl...) (heparan sulfate) serine | |||
Glycosylation | 490 | O-linked (Xyl...) (heparan sulfate) serine | |||
Post-translational modification
O-glycosylated with heparan sulfate side chains.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 346-369 | Disordered | |||
Compositional bias | 350-367 | Basic and acidic residues | |||
Sequence similarities
Belongs to the glypican family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length554
- Mass (Da)62,450
- Last updated2006-09-05 v1
- MD5 Checksum4242CB5C8D2E5476FA75922EFECA7202
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 350-367 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAMC01022256 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01022257 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC121374 EMBL· GenBank· DDBJ | AAI21375.1 EMBL· GenBank· DDBJ | mRNA |