Q0TJV1 · NADA_ECOL5
- ProteinQuinolinate synthase
- GenenadA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids347 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Catalytic activity
- iminosuccinate + dihydroxyacetone phosphate = quinolinate + phosphate + 2 H2O + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from iminoaspartate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 47 | iminosuccinate (UniProtKB | ChEBI) | |||
Binding site | 68 | iminosuccinate (UniProtKB | ChEBI) | |||
Binding site | 113 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 139-141 | iminosuccinate (UniProtKB | ChEBI) | |||
Binding site | 156 | iminosuccinate (UniProtKB | ChEBI) | |||
Binding site | 200 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 226-228 | iminosuccinate (UniProtKB | ChEBI) | |||
Binding site | 243 | iminosuccinate (UniProtKB | ChEBI) | |||
Binding site | 297 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Molecular Function | quinolinate synthetase A activity | |
Biological Process | 'de novo' NAD biosynthetic process from aspartate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameQuinolinate synthase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionQ0TJV1
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000024954 | 1-347 | Quinolinate synthase | ||
Structure
Sequence
- Sequence statusComplete
- Length347
- Mass (Da)38,184
- Last updated2006-09-05 v1
- ChecksumFC23BC67FA08DA58
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000247 EMBL· GenBank· DDBJ | ABG68780.1 EMBL· GenBank· DDBJ | Genomic DNA |