Q0TJV1 · NADA_ECOL5

Function

function

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from iminoaspartate: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site47iminosuccinate (UniProtKB | ChEBI)
Binding site68iminosuccinate (UniProtKB | ChEBI)
Binding site113[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site139-141iminosuccinate (UniProtKB | ChEBI)
Binding site156iminosuccinate (UniProtKB | ChEBI)
Binding site200[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site226-228iminosuccinate (UniProtKB | ChEBI)
Binding site243iminosuccinate (UniProtKB | ChEBI)
Binding site297[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Molecular Functionquinolinate synthetase A activity
Biological Process'de novo' NAD biosynthetic process from aspartate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Quinolinate synthase
  • EC number

Gene names

    • Name
      nadA
    • Ordered locus names
      ECP_0761

Organism names

Accessions

  • Primary accession
    Q0TJV1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000249541-347Quinolinate synthase

Structure

Family & Domains

Sequence similarities

Belongs to the quinolinate synthase family. Type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    38,184
  • Last updated
    2006-09-05 v1
  • Checksum
    FC23BC67FA08DA58
MSVMFDPDTAIYPFPPKPTPLSIDEKAYYREKIKRLLKERNAVMVAHYYTDPEIQQLAEETGGCISDSLEMARFGAKHPASTLLVAGVRFMGETAKILSPEKTILMPTLQAECSLDLGCPVEEFNAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIDHLDSLGEKIIWAPDKHLGCYVQKQTGADILCWQGACIVHDEFKTQALTRLQEEYPDAAILVHPESPQAIVEMADAVGSTSQLIAAAKTLPHQRLIVATDRGIFYKMQQAVPDKELLEAPTAGEGATCRSCAHCPWMAMNGLQAIAEALELEGSNHEVYVDERLLERALVPLNRMLDFAATLRG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000247
EMBL· GenBank· DDBJ
ABG68780.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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